| FMR LLC |
| 0.01% | 0.02% | #70 | $305.0M | 16.6M | $300.8M | 15.4M | +1.2M+7.97% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #110 | $157.1M | 8.6M | $153.2M | 7.8M | +720,013+9.19% | Add |
| Bellevue Group AG |
| 2.6% | 3.13% | #6 | $123.7M | 6.7M | $131.6M | 6.7M | +5,765+0.09% | Add |
| Paradigm Biocapital Advisors LP |
| 2.31% | 1.26% | #8 | $123.5M | 6.7M | $61.6M | 3.1M | +3.6M+113.53% | Add |
| Kynam Capital Management, LP |
| 6.55% | 2.83% | #1 | $118.6M | 6.5M | $45.8M | 2.3M | +4.1M+175.61% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #101 | $112.5M | 6.1M | $91.4M | 4.7M | +1.5M+31.07% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #71 | $105.6M | 5.7M | $62.7M | 3.2M | +2.5M+79.30% | Add |
| Fairmount Funds Management LLC |
| 6.18% | 5.53% | #2 | $93.5M | 5.1M | $76.6M | 3.9M | +1.2M+30.05% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #122 | $84.1M | 4.6M | $81.5M | 4.2M | +409,659+9.83% | Add |
| Deep Track Capital, LP |
| 0.96% | 0.45% | #16 | $66.0M | 3.6M | $27.3M | 1.4M | +2.2M+157.74% | Add |
| Venrock Adviser, LLC |
| 1.81% | 2.83% | #11 | $59.8M | 3.3M | $75.9M | 3.9M | -624,792-16.09% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | 0.01% | #75 | $57.5M | 3.1M | $60.2M | 3.1M | +49,808+1.62% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #111 | $50.6M | 2.8M | $32.1M | 1.6M | +1.1M+67.70% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #108 | $46.0M | 2.5M | $45.6M | 2.3M | +168,656+7.23% | Add |
| Avoro Capital Advisors LLC |
| 0.41% | 0.29% | #23 | $45.9M | 2.5M | $29.3M | 1.5M | +1.0M+66.67% | Add |
| BAKER BROS. ADVISORS LP |
| 0.22% | 0.22% | #29 | $43.8M | 2.4M | $38.6M | 2.0M | +411,347+20.86% | Add |
| Point72 Asset Management, L.P. |
| 0.05% | 0.01% | #53 | $43.3M | 2.4M | $6.3M | 322,836 | +2.0M+629.85% | Add |
| Caligan Partners LP |
| 1.9% | — | #10 | $40.3M | 2.2M | $0 | 0 | +2.2M | New Buy |
| Novo Holdings A/S |
| 2.28% | 3.17% | #9 | $39.2M | 2.1M | $39.1M | 2.0M | +135,000+6.75% | Add |
| TANG CAPITAL MANAGEMENT LLC |
| 1.5% | 1.78% | #14 | $32.9M | 1.8M | $35.1M | 1.8M | 00.00% | Unchanged |
| Fisher Asset Management, LLC |
| 0.01% | 0.01% | #77 | $32.2M | 1.8M | $34.6M | 1.8M | -17,445-0.99% | Reduce |
| Candriam S.C.A. |
| 0.14% | 0.12% | #34 | $31.3M | 1.7M | $24.4M | 785,098 | +922,600+117.51% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #103 | $31.1M | 1.7M | $31.1M | 1.6M | +99,359+6.24% | Add |
| First Turn Management, LLC |
| 3.28% | 1.99% | #4 | $30.7M | 1.7M | $17.8M | 911,337 | +758,663+83.25% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | <0.01% | #85 | $29.6M | 1.6M | $10.4M | 529,763 | +1.1M+204.20% | Add |
| ALLIANCEBERNSTEIN L.P. |
| 0.01% | 0.01% | #78 | $27.2M | 1.4M | $43.3M | 1.4M | -433-0.03% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #99 | $26.2M | 1.4M | $6.0M | 307,134 | +1.1M+365.22% | Add |
| Parkman Healthcare Partners LLC |
| 2.59% | 1.13% | #7 | $25.3M | 1.4M | $10.9M | 557,936 | +819,640+146.91% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.06% | #61 | $23.5M | 1.3M | $45.3M | 2.3M | -1.0M-44.74% | Reduce |
| D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #72 | $21.7M | 1.2M | $24.7M | 1.3M | -80,318-6.36% | Reduce |
| RICE HALL JAMES & ASSOCIATES, LLC |
| 1.05% | 0.98% | #15 | $21.6M | 1.2M | $17.6M | 898,611 | +277,295+30.86% | Add |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.01% | <0.01% | #79 | $20.4M | 1.1M | $455,337 | 23,279 | +1.1M+4,678.61% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | <0.01% | #80 | $18.6M | 1.0M | $5.2M | 266,399 | +745,739+279.93% | Add |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | <0.01% | #100 | $18.4M | 999,915 | $17.4M | 888,298 | +111,617+12.57% | Add |
| Elmind Capital, LP |
| 4.55% | 2.97% | #3 | $18.1M | 984,931 | $10.5M | 534,931 | +450,000+84.12% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #135 | $17.3M | 944,345 | $22.8M | 1.2M | -219,270-18.84% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #119 | $15.9M | 863,491 | $13.6M | 696,999 | +166,492+23.89% | Add |
| Eversept Partners, LP |
| 0.79% | 0.74% | #18 | $15.3M | 831,142 | $14.0M | 713,269 | +117,873+16.53% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #116 | $15.0M | 815,027 | $14.2M | 727,937 | +87,090+11.96% | Add |
| Schonfeld Strategic Advisors LLC |
| 0.05% | — | #50 | $14.6M | 793,508 | $0 | 0 | +793,508 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.02% | 0.01% | #65 | $14.1M | 768,600 | $4.0M | 203,100 | +565,500+278.43% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #150 | $13.4M | 728,817 | $4.1M | 191,941 | +536,876+279.71% | Add |
| Woodline Partners LP |
| 0.04% | 0.05% | #56 | $12.9M | 700,929 | $13.7M | 700,929 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #153 | $12.1M | 639,929 | $19.6M | 1.1M | -419,935-39.62% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #104 | $12.1M | 657,588 | $11.6M | 591,225 | +66,363+11.22% | Add |
| PERCEPTIVE ADVISORS LLC |
| 0.16% | 0.45% | #32 | $10.7M | 581,980 | $22.9M | 1.2M | -588,849-50.29% | Reduce |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.13% | — | #35 | $9.9M | 541,058 | $0 | 0 | +541,058 | New Buy |
| EMERALD ADVISERS, LLC |
| 0.23% | — | #27 | $9.9M | 537,328 | $0 | 0 | +537,328 | New Buy |
| DEUTSCHE BANK AG\ |
| <0.01% | 0.01% | #105 | $8.9M | 482,875 | $20.2M | 1.0M | -549,441-53.22% | Reduce |
| ALGERT GLOBAL LLC |
| 0.11% | 0.17% | #42 | $8.9M | 482,237 | $11.0M | 563,999 | -81,762-14.50% | Reduce |
