| Frazier Life Sciences Management, L.P. |
| 0.26% | 0.37% | #2 | $12.0M | 2.3M | $14.3M | 2.3M | 00.00% | Unchanged |
| Vivo Capital, LLC |
| 0.36% | — | #1 | $4.0M | 763,199 | $0 | 0 | +763,199 | New Buy |
| GENERAL AMERICAN INVESTORS CO INC |
| 0.11% | 0.15% | #3 | $1.9M | 354,361 | $2.2M | 354,361 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #9 | $707,216 | 135,223 | $0 | 0 | +135,223 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #10 | $403,829 | 77,214 | $487,681 | 78,029 | -815-1.04% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #12 | $294,014 | 56,217 | $402,442 | 32,987 | +23,230+70.42% | Add |
| IRONWOOD INVESTMENT MANAGEMENT LLC |
| 0.08% | 0.07% | #4 | $235,685 | 45,064 | $157,094 | 25,135 | +19,929+79.29% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | — | #14 | $106,138 | 20,294 | $0 | 0 | +20,294 | New Buy |
| XTX Topco Ltd |
| <0.01% | — | #6 | $79,381 | 15,178 | $0 | 0 | +15,178 | New Buy |
| VSM Wealth Advisory, LLC |
| 0.01% | 0.02% | #5 | $52,300 | 10,000 | $62,500 | 10,000 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #17 | $23,666 | 4,525 | $4,888 | 782 | +3,743+478.64% | Add |
| GAMMA Investing LLC |
| <0.01% | <0.01% | #7 | $21,385 | 4,089 | $8,913 | 1,426 | +2,663+186.75% | Add |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #15 | $9,727 | 1,860 | $11,205 | 1,793 | +67+3.74% | Add |
| Steigerwald, Gordon & Koch Inc. |
| <0.01% | <0.01% | #8 | $6,538 | 1,250 | $7,813 | 1,250 | 00.00% | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #18 | $2,924 | 559 | $1,250 | 200 | +359+179.50% | Add |
| Larson Financial Group LLC |
| <0.01% | — | #11 | $1,961 | 375 | $0 | 0 | +375 | New Buy |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #20 | $471 | 90 | $344 | 55 | +35+63.64% | Add |
| Smartleaf Asset Management LLC |
| <0.01% | <0.01% | #16 | $222 | 43 | $266 | 43 | 00.00% | Unchanged |
| Caitong International Asset Management Co., Ltd |
| <0.01% | — | #13 | $94 | 18 | $0 | 0 | +18 | New Buy |
| Activest Wealth Management |
| <0.01% | <0.01% | #19 | $5 | 1 | $6 | 1 | 00.00% | Unchanged |