| TANG CAPITAL MANAGEMENT LLC |
| 10.05% | 9.2% | #1 | $221.4M | 13.0M | $181.2M | 12.2M | +814,606+6.66% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #129 | $139.0M | 8.2M | $116.3M | 7.8M | +347,564+4.43% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #81 | $95.4M | 5.6M | $21.2M | 1.4M | +4.2M+292.00% | Add |
| NEA Management Company, LLC |
| 4.24% | 3.34% | #2 | $67.4M | 4.0M | $58.8M | 4.0M | 00.00% | Unchanged |
| TWO SIGMA INVESTMENTS, LP |
| 0.04% | 0.04% | #38 | $58.8M | 3.5M | $50.8M | 3.4M | +38,809+1.13% | Add |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.02% | 0.03% | #53 | $55.4M | 3.3M | $48.7M | 3.3M | -20,306-0.62% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #153 | $43.9M | 2.6M | $37.5M | 2.5M | +62,516+2.47% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #128 | $39.2M | 2.3M | $21.5M | 1.9M | +361,459+18.57% | Add |
| MARSHALL WACE, LLP |
| 0.03% | 0.03% | #46 | $34.7M | 2.0M | $27.8M | 1.9M | +169,410+9.04% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #146 | $28.9M | 1.7M | $22.8M | 1.5M | +165,143+10.75% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.04% | 0.04% | #43 | $26.3M | 1.5M | $24.7M | 1.7M | -115,800-6.96% | Reduce |
| D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #72 | $23.9M | 1.4M | $23.3M | 1.6M | -164,527-10.46% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #168 | $23.1M | 1.4M | $18.6M | 1.3M | +102,667+8.17% | Add |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.08% | 0.07% | #29 | $20.9M | 1.2M | $16.3M | 1.1M | +134,327+12.24% | Add |
| Caption Management, LLC |
| 0.1% | 0.01% | #25 | $20.8M | 1.2M | $1.5M | 99,700 | +1.1M+1,128.05% | Add |
| JUPITER ASSET MANAGEMENT LTD |
| 0.09% | 0.06% | #26 | $18.6M | 1.1M | $11.9M | 803,419 | +291,056+36.23% | Add |
| LSV ASSET MANAGEMENT |
| 0.03% | 0.03% | #44 | $18.3M | 1.1M | $15.4M | 1.0M | +39,871+3.84% | Add |
| NOMURA HOLDINGS INC |
| 0.02% | 0.04% | #61 | $16.6M | 978,602 | $14.4M | 968,910 | +9,692+1.00% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #89 | $16.1M | 948,751 | $14.1M | 948,810 | -59-0.01% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #144 | $14.7M | 863,567 | $12.2M | 824,105 | +39,462+4.79% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #110 | $13.8M | 812,915 | $9.7M | 653,424 | +159,491+24.41% | Add |
| Jupiter Topco LLC |
| <0.01% | — | #103 | $10.2M | 602,195 | $0 | 0 | +602,195 | New Buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main |
| 0.01% | 0.01% | #85 | $10.1M | 596,618 | $9.1M | 615,091 | -18,473-3.00% | Reduce |
| PRUDENTIAL FINANCIAL INC |
| 0.01% | 0.01% | #73 | $9.9M | 582,345 | $8.8M | 590,610 | -8,265-1.40% | Reduce |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC |
| 0.04% | 0.03% | #36 | $9.6M | 567,492 | $6.1M | 414,019 | +153,473+37.07% | Add |
| Hillsdale Investment Management Inc. |
| 0.21% | 0.08% | #14 | $9.3M | 550,900 | $3.1M | 209,900 | +341,000+162.46% | Add |
| Qube Research & Technologies Ltd |
| 0.01% | 0.02% | #86 | $8.1M | 479,970 | $13.8M | 930,631 | -450,661-48.43% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #176 | $7.9M | 465,185 | $6.0M | 406,674 | +58,511+14.39% | Add |
| Woodline Partners LP |
| 0.02% | 0.03% | #55 | $7.7M | 456,259 | $6.8M | 456,259 | 00.00% | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #171 | $7.6M | 445,990 | $6.8M | 461,866 | -15,876-3.44% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | 0.01% | #108 | $7.4M | 437,037 | $11.1M | 748,765 | -311,728-41.63% | Reduce |
| RICE HALL JAMES & ASSOCIATES, LLC |
| 0.34% | 0.4% | #8 | $7.1M | 416,631 | $7.2M | 487,898 | -71,267-14.61% | Reduce |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #160 | $7.0M | 411,825 | $4.1M | 275,154 | +136,671+49.67% | Add |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.01% | 0.01% | #67 | $6.9M | 408,453 | $5.9M | 395,405 | +13,048+3.30% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #204 | $6.4M | 378,035 | $3.8M | 253,337 | +124,698+49.22% | Add |
| FMR LLC |
| <0.01% | <0.01% | #234 | $6.3M | 372,481 | $4.7M | 318,778 | +53,703+16.85% | Add |
| RITHOLTZ WEALTH MANAGEMENT |
| 0.09% | 0.08% | #27 | $6.2M | 363,056 | $4.7M | 314,426 | +48,630+15.47% | Add |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
| 0.03% | 0.03% | #48 | $6.2M | 362,416 | $7.8M | 528,172 | -165,756-31.38% | Reduce |
| IFP Advisors, Inc |
| 0.11% | 0.1% | #23 | $6.1M | 361,634 | $4.9M | 327,791 | +33,843+10.32% | Add |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #114 | $6.0M | 355,572 | $5.4M | 365,236 | -9,664-2.65% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #173 | $6.0M | 350,857 | $5.0M | 335,775 | +15,082+4.49% | Add |
| Norris Financial Group, LLC |
| 2.31% | 1.66% | #3 | $5.8M | 342,331 | $5.1M | 342,477 | -146-0.04% | Reduce |
| Squarepoint Ops LLC |
| 0.01% | 0.01% | #88 | $5.4M | 317,430 | $4.7M | 319,804 | -2,374-0.74% | Reduce |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #149 | $5.3M | 310,564 | $3.9M | 265,757 | +44,807+16.86% | Add |
| NORDEA INVESTMENT MANAGEMENT AB |
| <0.01% | <0.01% | #104 | $5.0M | 296,200 | $4.2M | 292,200 | +4,000+1.37% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #235 | $5.0M | 291,351 | $4.5M | 323,685 | -32,334-9.99% | Reduce |
| PDT Partners, LLC |
| 0.24% | 0.23% | #13 | $4.5M | 265,491 | $3.9M | 265,491 | 00.00% | Unchanged |
| SEGALL BRYANT & HAMILL, LLC |
| 0.05% | 0.03% | #33 | $4.5M | 263,743 | $2.2M | 146,279 | +117,464+80.30% | Add |
| NAVELLIER & ASSOCIATES INC |
| 0.35% | 0.18% | #7 | $4.4M | 257,142 | $1.7M | 114,936 | +142,206+123.73% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #151 | $4.1M | 244,302 | $1.7M | 117,169 | +127,133+108.50% | Add |
