| FMR LLC |
| 0.01% | 0.01% | #73 | $322.5M | 32.8M | $276.6M | 32.7M | +190,279+0.58% | Add |
| Deep Track Capital, LP |
| 2.81% | 2.72% | #6 | $193.3M | 19.7M | $166.7M | 19.7M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #116 | $190.3M | 19.4M | $136.6M | 16.1M | +3.2M+20.11% | Add |
| Avoro Capital Advisors LLC |
| 1.11% | 1.03% | #15 | $123.1M | 12.5M | $104.3M | 12.3M | +225,000+1.83% | Add |
| SUMMER ROAD LLC |
| 74.46% | 70.84% | #1 | $119.9M | 12.2M | $100.6M | 11.9M | +328,471+2.76% | Add |
| Venrock Adviser, LLC |
| 3.08% | 3.27% | #5 | $101.6M | 10.3M | $87.6M | 10.3M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #137 | $86.7M | 8.8M | $73.9M | 8.7M | +113,556+1.30% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #91 | $74.9M | 7.6M | $50.0M | 5.9M | +1.7M+29.27% | Add |
| Logos Global Management LP |
| 2.24% | 1.63% | #7 | $52.0M | 5.3M | $32.6M | 3.9M | +1.5M+37.66% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #145 | $51.4M | 5.2M | $39.9M | 4.7M | +524,863+11.15% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #120 | $49.3M | 5.0M | $38.4M | 4.5M | +491,907+10.86% | Add |
| Point72 Asset Management, L.P. |
| 0.04% | 0.06% | #53 | $32.3M | 3.3M | $46.9M | 5.5M | -2.2M-40.52% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.04% | 0.03% | #51 | $31.9M | 3.2M | $22.8M | 2.7M | +553,285+20.55% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #98 | $27.3M | 2.8M | $5.5M | 649,756 | +2.1M+328.37% | Add |
| DELTEC ASSET MANAGEMENT LLC |
| 3.59% | 3.64% | #4 | $24.3M | 2.5M | $19.8M | 2.3M | +135,577+5.79% | Add |
| Octagon Capital Advisors LP |
| 1.83% | 2.97% | #12 | $20.4M | 2.1M | $26.8M | 3.2M | -1.1M-34.47% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #170 | $19.4M | 2.0M | $13.5M | 1.6M | +378,464+23.73% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #129 | $17.7M | 1.8M | $12.9M | 1.5M | +273,800+17.95% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #146 | $17.3M | 1.8M | $9.4M | 1.1M | +651,388+58.66% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #107 | $16.7M | 1.7M | $3.5M | 411,080 | +1.3M+312.88% | Add |
| Woodline Partners LP |
| 0.05% | 0.05% | #42 | $16.4M | 1.7M | $14.1M | 1.7M | 00.00% | Unchanged |
| TCG Crossover Management, LLC |
| 0.39% | 0.4% | #26 | $16.2M | 1.6M | $14.0M | 1.6M | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #134 | $15.2M | 1.6M | $12.9M | 1.5M | +30,370+2.00% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | — | #64 | $15.2M | 1.6M | $0 | 0 | +1.6M | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #131 | $15.1M | 1.5M | $12.4M | 1.5M | +72,261+4.95% | Add |
| Defilade Capital Management, L.P. |
| 1.96% | 1.77% | #9 | $14.6M | 1.5M | $12.6M | 1.5M | +2,641+0.18% | Add |
| Squarepoint Ops LLC |
| 0.02% | 0.01% | #71 | $13.9M | 1.4M | $8.3M | 980,757 | +435,156+44.37% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #163 | $13.2M | 1.3M | $13.0M | 1.5M | -192,388-12.52% | Reduce |
| Boxer Capital Management, LLC |
| 0.96% | 0.39% | #17 | $12.8M | 1.3M | $3.0M | 350,000 | +950,000+271.43% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #117 | $12.7M | 1.3M | $10.5M | 1.2M | +44,176+3.55% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #85 | $12.0M | 1.2M | $15.5M | 1.8M | -611,646-33.42% | Reduce |
| Knoll Capital Management, LLC |
| 6.48% | 2.69% | #2 | $11.3M | 1.2M | $5.1M | 600,400 | +550,000+91.61% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #169 | $11.2M | 1.1M | $6.6M | 775,544 | +369,176+47.60% | Add |
| HRT FINANCIAL LP |
| 0.02% | 0.02% | #68 | $10.6M | 1.1M | $6.0M | 709,218 | +367,872+51.87% | Add |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #121 | $9.5M | 963,316 | $7.3M | 859,485 | +103,831+12.08% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #113 | $9.3M | 950,338 | $4.2M | 499,339 | +450,999+90.32% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #198 | $9.0M | 911,831 | $28.8M | 2.5M | -1.6M-63.02% | Reduce |
| Candriam S.C.A. |
| 0.04% | 0.05% | #49 | $8.9M | 907,839 | $10.2M | 841,602 | +66,237+7.87% | Add |
| Empire Life Investments Inc. |
| 0.48% | 0.45% | #24 | $8.6M | 871,692 | $7.4M | 884,297 | -12,605-1.43% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #166 | $8.0M | 815,584 | $9.6M | 1.1M | -313,138-27.74% | Reduce |
| Cetera Investment Advisers |
| 0.01% | 0.01% | #92 | $7.7M | 785,732 | $6.5M | 764,615 | +21,117+2.76% | Add |
| READYSTATE ASSET MANAGEMENT LP |
| 0.38% | 0.34% | #27 | $7.5M | 883,621 | $7.5M | 883,621 | 00.00% | Unchanged |
| PEREGRINE CAPITAL MANAGEMENT LLC |
| 0.24% | 0.23% | #29 | $7.4M | 753,495 | $6.1M | 720,462 | +33,033+4.58% | Add |
| TUDOR INVESTMENT CORP ET AL |
| 0.01% | 0.02% | #81 | $6.8M | 694,063 | $13.2M | 1.6M | -862,415-55.41% | Reduce |
| Aptus Capital Advisors, LLC |
| 0.04% | 0.04% | #46 | $6.3M | 638,691 | $4.5M | 529,779 | +108,912+20.56% | Add |
| Second Line Capital, LLC |
| 1.17% | 0.94% | #14 | $6.3M | 638,640 | $5.0M | 528,290 | +110,350+20.89% | Add |
| Opaleye Management Inc. |
| 0.53% | 0.67% | #23 | $5.9M | 600,000 | $5.1M | 600,000 | 00.00% | Unchanged |
| ALGERT GLOBAL LLC |
| 0.07% | 0.07% | #41 | $5.8M | 592,309 | $4.6M | 538,939 | +53,370+9.90% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #167 | $5.4M | 553,236 | $4.0M | 475,987 | +77,249+16.23% | Add |
| Man Group plc |
| 0.01% | <0.01% | #86 | $5.3M | 543,582 | $1.5M | 177,468 | +366,114+206.30% | Add |
