| FMR LLC |
| 0.02% | 0.02% | #65 | $432.7M | 12.6M | $296.7M | 12.5M | +156,803+1.26% | Add |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 1.62% | 1.38% | #9 | $351.3M | 10.2M | $241.5M | 10.1M | +101,700+1.00% | Add |
| ARK Investment Management LLC |
| 2.27% | 2.25% | #7 | $351.3M | 10.2M | $289.1M | 12.1M | -1.9M-15.65% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #109 | $308.8M | 9.0M | $202.3M | 8.5M | +509,973+6.01% | Add |
| STATE STREET CORP |
| 0.01% | <0.01% | #106 | $200.0M | 5.8M | $135.8M | 5.7M | +127,857+2.24% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #87 | $168.9M | 4.9M | $108.9M | 4.6M | +350,462+7.67% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #129 | $157.9M | 4.6M | $104.3M | 4.4M | +222,063+5.07% | Add |
| ARCH Venture Management, LLC |
| 14.16% | 15.98% | #1 | $155.8M | 4.5M | $108.2M | 4.5M | 00.00% | Unchanged |
| Sumitomo Mitsui Trust Group, Inc. |
| 0.07% | 0.06% | #42 | $118.6M | 3.5M | $91.2M | 3.8M | -370,542-9.69% | Reduce |
| Amova Asset Management Americas, Inc. |
| 1.53% | 1.29% | #10 | $118.5M | 3.5M | $91.2M | 3.8M | -370,542-9.69% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #74 | $117.2M | 3.4M | $64.7M | 2.7M | +702,009+25.87% | Add |
| Kynam Capital Management, LP |
| 5.39% | 5.41% | #2 | $97.5M | 2.8M | $87.7M | 3.7M | -841,393-22.85% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #108 | $89.1M | 2.6M | $57.6M | 2.4M | +178,371+7.37% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #70 | $76.4M | 2.2M | $51.3M | 2.2M | +71,269+3.31% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #125 | $67.0M | 2.0M | $15.6M | 644,760 | +1.3M+202.59% | Add |
| Contrarius Group Holdings Ltd |
| 2.55% | 0.72% | #5 | $55.4M | 1.6M | $12.7M | 533,443 | +1.1M+202.66% | Add |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.01% | 0.01% | #82 | $53.3M | 1.6M | $39.4M | 1.7M | -101,933-6.16% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| 0.03% | 0.02% | #54 | $47.6M | 1.4M | $28.9M | 1.2M | +177,374+14.65% | Add |
| Casdin Capital, LLC |
| 2.32% | 2.44% | #6 | $46.3M | 1.4M | $32.2M | 1.4M | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #120 | $45.0M | 1.3M | $24.0M | 1.0M | +304,316+30.26% | Add |
| Redmile Group, LLC |
| 2.68% | 1.95% | #4 | $40.0M | 1.2M | $29.5M | 1.2M | -73,400-5.93% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.02% | 0.01% | #68 | $36.6M | 1.1M | $16.7M | 700,647 | +367,236+52.41% | Add |
| Deep Track Capital, LP |
| 0.5% | 0.32% | #15 | $34.3M | 1.0M | $19.6M | 820,765 | +179,235+21.84% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #122 | $32.0M | 933,481 | $19.7M | 825,580 | +107,901+13.07% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #116 | $30.4M | 885,902 | $19.3M | 808,436 | +77,466+9.58% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #156 | $24.7M | 720,648 | $12.8M | 538,290 | +182,358+33.88% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | <0.01% | #107 | $24.4M | 710,712 | $16.3M | 684,870 | +25,842+3.77% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #141 | $19.7M | 574,814 | $19.7M | 826,061 | -251,247-30.42% | Reduce |
| RTW INVESTMENTS, LP |
| 0.17% | 0.14% | #28 | $19.6M | 570,394 | $13.6M | 570,394 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #171 | $18.1M | 514,767 | $12.1M | 551,355 | -36,588-6.64% | Reduce |
| MARSHALL WACE, LLP |
| 0.01% | <0.01% | #72 | $16.4M | 478,980 | $3.3M | 139,241 | +339,739+243.99% | Add |
| Elmind Capital, LP |
| 4.11% | 3.22% | #3 | $16.3M | 476,338 | $11.4M | 476,338 | 00.00% | Unchanged |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd |
| 1% | 0.88% | #14 | $15.6M | 455,954 | $11.6M | 488,417 | -32,463-6.65% | Reduce |
| JUPITER ASSET MANAGEMENT LTD |
| 0.08% | <0.01% | #41 | $15.3M | 445,718 | $573,350 | 24,060 | +421,658+1,752.53% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.02% | 0.02% | #59 | $15.3M | 445,000 | $12.2M | 513,578 | -68,578-13.35% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #163 | $13.7M | 399,579 | $13.3M | 556,591 | -157,012-28.21% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #148 | $12.5M | 362,800 | $8.2M | 344,486 | +18,314+5.32% | Add |
| Foresite Capital Management VI LLC |
| 1.76% | — | #8 | $11.3M | 330,000 | $0 | 0 | +330,000 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #162 | $10.8M | 315,700 | $19.2M | 806,070 | -490,370-60.83% | Reduce |
| BAILLIE GIFFORD & CO |
| 0.01% | 0.01% | #80 | $10.8M | 314,228 | $9.2M | 385,891 | -71,663-18.57% | Reduce |
| Integral Health Asset Management, LLC |
| 0.41% | 0.34% | #19 | $10.3M | 300,000 | $7.1M | 300,000 | 00.00% | Unchanged |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | — | #110 | $10.2M | 296,294 | $0 | 0 | +296,294 | New Buy |
| Pictet Asset Management Holding SA |
| 0.01% | 0.01% | #84 | $8.8M | 250,797 | $6.5M | 297,504 | -46,707-15.70% | Reduce |
| Nuveen, LLC |
| <0.01% | <0.01% | #149 | $8.4M | 245,283 | $5.5M | 232,596 | +12,687+5.45% | Add |
| Alphabet Inc. |
| 0.18% | 0.19% | #25 | $7.7M | 321,604 | $7.7M | 321,604 | 00.00% | Unchanged |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #135 | $7.0M | 204,697 | $4.0M | 168,673 | +36,024+21.36% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #190 | $6.7M | 194,171 | $5.2M | 219,961 | -25,790-11.72% | Reduce |
| Qube Research & Technologies Ltd |
| 0.01% | 0.03% | #102 | $6.7M | 194,083 | $25.9M | 1.1M | -890,685-82.11% | Reduce |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #164 | $6.5M | 189,389 | $3.2M | 132,249 | +57,140+43.21% | Add |
| MACKENZIE FINANCIAL CORP |
| 0.01% | — | #103 | $6.4M | 185,499 | $0 | 0 | +185,499 | New Buy |
