| Frazier Life Sciences Management, L.P. |
| 9.96% | 10.27% | #2 | $457.5M | 25.0M | $399.2M | 24.7M | +300,000+1.22% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.25% | 0.24% | #38 | $388.1M | 21.2M | $344.0M | 21.3M | -73,807-0.35% | Reduce |
| BlackRock, Inc. |
| 0.01% | 0.01% | #111 | $387.5M | 21.2M | $326.0M | 20.2M | +1.0M+4.98% | Add |
| RTW INVESTMENTS, LP |
| 2.81% | 2.6% | #14 | $328.8M | 17.9M | $261.4M | 16.2M | +1.8M+11.08% | Add |
| Venrock Adviser, LLC |
| 9.94% | 9.89% | #3 | $327.8M | 17.9M | $265.1M | 16.4M | +1.5M+9.21% | Add |
| STATE STREET CORP |
| 0.01% | 0.01% | #100 | $223.2M | 12.2M | $150.5M | 9.3M | +2.9M+31.02% | Add |
| Logos Global Management LP |
| 9.58% | 9.01% | #4 | $222.6M | 12.2M | $180.4M | 11.2M | +1.0M+8.97% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #128 | $208.9M | 11.4M | $182.0M | 11.2M | +152,461+1.36% | Add |
| Siren, L.L.C. |
| 4.23% | 5.04% | #9 | $208.8M | 11.4M | $181.9M | 11.2M | +153,535+1.37% | Add |
| Paradigm Biocapital Advisors LP |
| 3.28% | 3.44% | #13 | $175.0M | 9.6M | $168.2M | 10.4M | -842,702-8.11% | Reduce |
| ARCH Venture Management, LLC |
| 11.81% | 16.95% | #1 | $129.9M | 7.1M | $114.7M | 7.1M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #103 | $119.1M | 6.5M | $97.0M | 6.0M | +505,277+8.43% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #79 | $114.9M | 6.3M | $29.4M | 1.8M | +4.5M+245.53% | Add |
| Cormorant Asset Management, LP |
| 5.58% | 4.71% | #7 | $109.9M | 6.0M | $93.8M | 5.8M | +200,000+3.45% | Add |
| Caption Management, LLC |
| 0.47% | 0.06% | #29 | $100.9M | 5.5M | $9.9M | 612,500 | +4.9M+798.81% | Add |
| Affinity Asset Advisors, LLC |
| 4.35% | 4.47% | #8 | $96.2M | 5.3M | $86.6M | 5.4M | -100,000-1.87% | Reduce |
| Vivo Capital, LLC |
| 6.9% | 16.34% | #5 | $75.6M | 4.1M | $196.6M | 12.2M | -8.0M-66.03% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #105 | $70.0M | 3.8M | $78.9M | 4.9M | -1.1M-21.60% | Reduce |
| ALLIANCEBERNSTEIN L.P. |
| 0.02% | <0.01% | #71 | $66.6M | 4.1M | $9.8M | 2.6M | +1.5M+55.72% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #140 | $55.9M | 3.0M | $49.4M | 3.1M | -7,160-0.23% | Reduce |
| FMR LLC |
| <0.01% | <0.01% | #157 | $52.8M | 2.9M | $24.1M | 1.5M | +1.4M+93.51% | Add |
| Woodline Partners LP |
| 0.16% | 0.17% | #43 | $51.9M | 2.8M | $45.8M | 2.8M | +329+0.01% | Add |
| JENNISON ASSOCIATES LLC |
| 0.03% | — | #65 | $51.1M | 2.8M | $0 | 0 | +2.8M | New Buy |
| Soleus Capital Management, L.P. |
| 1.7% | — | #18 | $49.5M | 2.7M | $0 | 0 | +2.7M | New Buy |
| a16z Capital Management, L.L.C. |
| 3.69% | 3.59% | #11 | $46.3M | 2.9M | $46.3M | 2.9M | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #165 | $43.8M | 2.4M | $28.7M | 1.8M | +616,107+34.73% | Add |
| SAMLYN CAPITAL, LLC |
| 0.67% | — | #23 | $41.3M | 2.3M | $0 | 0 | +2.3M | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.02% | 0.01% | #76 | $37.4M | 2.0M | $17.6M | 1.1M | +954,733+87.81% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #134 | $35.9M | 2.0M | $27.5M | 1.7M | +256,497+15.07% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #126 | $35.6M | 1.9M | $30.7M | 1.9M | +46,566+2.45% | Add |
| VICTORY CAPITAL MANAGEMENT INC |
| 0.02% | 0.02% | #73 | $35.5M | 1.9M | $26.8M | 1.7M | +281,965+17.04% | Add |
| Nuveen, LLC |
| 0.01% | <0.01% | #90 | $33.7M | 1.8M | $8.8M | 543,021 | +1.3M+239.16% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #154 | $32.9M | 1.8M | $23.9M | 1.5M | +314,951+21.30% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #108 | $32.3M | 1.8M | $28.9M | 1.8M | -22,409-1.25% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #98 | $31.1M | 1.7M | $24.9M | 1.5M | +160,076+10.41% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #138 | $29.3M | 1.6M | $29.9M | 1.8M | -251,918-13.63% | Reduce |
| STEMPOINT CAPITAL LP |
| 4.1% | 0.72% | #10 | $28.8M | 1.8M | $3.9M | 239,861 | +1.5M+636.22% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #159 | $27.2M | 1.5M | $10.0M | 617,619 | +864,388+139.95% | Add |
| Rock Springs Capital Management LP |
| 1.25% | 1.05% | #20 | $25.7M | 1.4M | $17.9M | 1.1M | +298,681+27.07% | Add |
| Evergreen Quality Fund GP, Ltd. |
| 0.41% | — | #31 | $25.2M | 1.4M | $0 | 0 | +1.4M | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.03% | 0.04% | #64 | $25.1M | 1.4M | $22.6M | 1.4M | -29,951-2.14% | Reduce |
| FRED ALGER MANAGEMENT, LLC |
| 0.08% | 0.02% | #53 | $24.0M | 1.3M | $3.8M | 236,824 | +1.1M+452.50% | Add |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 2.4% | 3.06% | #15 | $23.1M | 1.3M | $30.0M | 1.9M | -588,786-31.80% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.11% | #67 | $23.0M | 1.3M | $83.2M | 5.1M | -3.9M-75.54% | Reduce |
| Octagon Capital Advisors LP |
| 2.07% | — | #17 | $23.0M | 1.3M | $0 | 0 | +1.3M | New Buy |
| Point72 Asset Management, L.P. |
| 0.03% | 0.01% | #70 | $22.8M | 1.2M | $11.2M | 693,309 | +553,894+79.89% | Add |
| First Turn Management, LLC |
| 2.39% | 1.57% | #16 | $22.4M | 1.2M | $14.0M | 867,639 | +354,082+40.81% | Add |
| FEDERATED HERMES, INC. |
| 0.03% | <0.01% | #69 | $19.8M | 1.1M | $16,261 | 1,005 | +1.1M+107,587.76% | Add |
| Integral Health Asset Management, LLC |
| 0.72% | 0.54% | #22 | $18.3M | 1.0M | $11.3M | 700,000 | +300,000+42.86% | Add |
| D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #88 | $17.4M | 949,590 | $19.7M | 1.2M | -269,944-22.14% | Reduce |
