| Vivo Capital, LLC |
| 3.49% | 3.17% | #1 | $38.2M | 5.9M | $38.2M | 5.9M | 00.00% | Unchanged |
| ORBIMED ADVISORS LLC |
| 0.31% | 3.66% | #3 | $16.3M | 2.7M | $184.5M | 2.7M | 00.00% | Unchanged |
| Neumann Advisory Hong Kong Ltd |
| 0.57% | 0.64% | #2 | $2.0M | 315,586 | $2.0M | 315,586 | 00.00% | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #4 | $106,302 | 16,430 | $106,302 | 16,430 | 00.00% | Unchanged |
| MORGAN STANLEY |
| <0.01% | <0.01% | #8 | $59,174 | 9,146 | $59,161 | 9,144 | +2+0.02% | Add |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #6 | $29,632 | 4,580 | $31,127 | 4,811 | -231-4.80% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #9 | $16,039 | 2,479 | $14,422 | 2,229 | +250+11.22% | Add |
| HARBOUR INVESTMENTS, INC. |
| <0.01% | <0.01% | #5 | $503 | 78 | $542 | 83 | -5-6.02% | Reduce |
| Horizon Investments, LLC |
| <0.01% | <0.01% | #7 | $336 | 52 | $673 | 104 | -52-50.00% | Reduce |
