| RTW INVESTMENTS, LP |
| 3.71% | 2.77% | #15 | $434.5M | 13.9M | $278.2M | 13.3M | +600,000+4.51% | Add |
| BlackRock, Inc. |
| 0.01% | <0.01% | #114 | $388.8M | 12.4M | $183.0M | 8.7M | +3.7M+42.19% | Add |
| FMR LLC |
| 0.02% | 0.01% | #87 | $385.5M | 12.3M | $207.2M | 9.9M | +2.4M+24.50% | Add |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 1.77% | 1.08% | #23 | $383.8M | 12.3M | $190.3M | 9.1M | +3.2M+34.95% | Add |
| Boxer Capital Management, LLC |
| 25.61% | 29.87% | #2 | $340.0M | 10.9M | $227.5M | 10.9M | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| 0.03% | 0.01% | #79 | $312.0M | 10.0M | $106.2M | 5.1M | +4.9M+96.61% | Add |
| TCG Crossover Management, LLC |
| 6.82% | 6.3% | #5 | $283.9M | 9.1M | $220.3M | 10.5M | -1.4M-13.77% | Reduce |
| Paradigm Biocapital Advisors LP |
| 3.72% | 1.71% | #14 | $198.7M | 6.4M | $83.9M | 4.0M | +2.3M+58.55% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | <0.01% | #85 | $198.5M | 6.3M | $18.6M | 889,400 | +5.5M+613.83% | Add |
| Siren, L.L.C. |
| 3.91% | 3.28% | #12 | $193.2M | 6.2M | $118.3M | 5.7M | +522,259+9.23% | Add |
| STATE STREET CORP |
| 0.01% | <0.01% | #117 | $186.9M | 6.0M | $97.3M | 4.7M | +1.3M+28.55% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #134 | $186.2M | 6.0M | $108.0M | 5.2M | +795,917+15.42% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.25% | 0.41% | #43 | $175.1M | 5.6M | $268.0M | 12.8M | -7.2M-56.28% | Reduce |
| Jupiter Topco LLC |
| 0.06% | — | #61 | $158.0M | 5.1M | $0 | 0 | +5.1M | New Buy |
| Deep Track Capital, LP |
| 1.91% | 0.94% | #21 | $131.3M | 4.2M | $57.5M | 2.8M | +1.5M+52.73% | Add |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.37% | 1.02% | #26 | $131.0M | 4.2M | $86.8M | 4.1M | +43,798+1.06% | Add |
| Woodline Partners LP |
| 0.39% | 0.63% | #39 | $125.1M | 4.0M | $167.4M | 8.0M | -4.0M-49.99% | Reduce |
| TRV GP IV, LLC |
| 47.37% | 49.96% | #1 | $120.2M | 6.4M | $133.4M | 6.4M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #111 | $117.0M | 3.7M | $56.0M | 2.7M | +1.1M+39.88% | Add |
| PERCEPTIVE ADVISORS LLC |
| 1.58% | 0.33% | #25 | $105.6M | 3.4M | $16.9M | 808,153 | +2.6M+317.87% | Add |
| Seven Fleet Capital Management LP |
| 15.79% | 3.33% | #3 | $95.7M | 3.2M | $10.5M | 502,012 | +2.7M+543.04% | Add |
| Logos Global Management LP |
| 3.84% | 3.13% | #13 | $89.1M | 2.9M | $62.8M | 3.0M | -150,000-5.00% | Reduce |
| Caligan Partners LP |
| 3.68% | 3.35% | #16 | $78.2M | 2.5M | $50.4M | 2.4M | +91,305+3.79% | Add |
| Holocene Advisors, LP |
| 0.17% | 0.2% | #48 | $75.4M | 2.4M | $82.3M | 3.9M | -1.5M-38.69% | Reduce |
| Commodore Capital LP |
| 4.19% | — | #10 | $70.3M | 2.3M | $0 | 0 | +2.3M | New Buy |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.08% | 0.1% | #57 | $66.2M | 2.1M | $80.1M | 3.8M | -1.7M-44.69% | Reduce |
| Jefferies Financial Group Inc. |
| 0.41% | — | #37 | $62.8M | 2.0M | $0 | 0 | +2.0M | New Buy |
| FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #93 | $59.0M | 1.9M | $27.1M | 1.3M | +590,928+45.59% | Add |
| Candriam S.C.A. |
| 0.23% | 0.03% | #44 | $50.9M | 1.6M | $6.3M | 708,812 | +921,741+130.04% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #148 | $49.6M | 1.6M | $18.9M | 901,466 | +683,645+75.84% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #146 | $46.3M | 1.4M | $1.3M | 67,326 | +1.4M+2,006.46% | Add |
| Polar Capital Holdings Plc |
| 0.11% | — | #53 | $46.3M | 1.5M | $0 | 0 | +1.5M | New Buy |
| Vivo Capital, LLC |
| 3.94% | 3.75% | #11 | $43.1M | 1.4M | $45.1M | 2.2M | -775,011-35.97% | Reduce |
| DV EQUITIES, LLC |
| 5.91% | — | #6 | $41.2M | 1.3M | $0 | 0 | +1.3M | New Buy |
| Cormorant Asset Management, LP |
| 2.06% | 1.5% | #20 | $40.6M | 1.3M | $29.8M | 1.4M | -125,000-8.77% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #127 | $38.5M | 1.2M | $18.1M | 862,940 | +368,993+42.76% | Add |
| STEMPOINT CAPITAL LP |
| 5.47% | 0.78% | #7 | $38.4M | 1.3M | $4.2M | 200,919 | +1.1M+558.48% | Add |
| FEDERATED HERMES, INC. |
| 0.05% | <0.01% | #65 | $38.0M | 1.2M | $7,406 | 354 | +1.2M+343,011.02% | Add |
| VOYA INVESTMENT MANAGEMENT LLC |
| 0.03% | <0.01% | #77 | $34.5M | 1.1M | $3.7M | 175,469 | +927,561+528.62% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #128 | $33.5M | 1.1M | $17.5M | 838,675 | +233,384+27.83% | Add |
| AMERICAN CENTURY COMPANIES INC |
| 0.01% | — | #89 | $31.7M | 1.0M | $0 | 0 | +1.0M | New Buy |
| Integral Health Asset Management, LLC |
| 1.23% | 0.45% | #27 | $31.3M | 1.0M | $9.4M | 450,000 | +550,000+122.22% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | <0.01% | #110 | $28.6M | 915,565 | $13.9M | 662,921 | +252,644+38.11% | Add |
| Nuveen, LLC |
| 0.01% | <0.01% | #108 | $27.8M | 890,170 | $7.5M | 360,818 | +529,352+146.71% | Add |
| SAMLYN CAPITAL, LLC |
| 0.39% | — | #38 | $24.0M | 766,473 | $0 | 0 | +766,473 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.03% | — | #75 | $23.4M | 748,300 | $0 | 0 | +748,300 | New Buy |
| Soleus Capital Management, L.P. |
| 0.76% | 0.38% | #32 | $22.2M | 709,000 | $9.4M | 450,000 | +259,000+57.56% | Add |
| ArrowMark Colorado Holdings LLC |
| 0.92% | 0.39% | #30 | $22.1M | 708,385 | $14.8M | 708,385 | 00.00% | Unchanged |
| Bellevue Group AG |
| 0.46% | 1.19% | #36 | $21.7M | 694,182 | $50.2M | 2.4M | -1.7M-71.08% | Reduce |
| Alyeska Investment Group, L.P. |
| 0.06% | <0.01% | #64 | $21.6M | 691,109 | $359,782 | 17,198 | +673,911+3,918.54% | Add |
