| BlackRock, Inc. |
| <0.01% | <0.01% | #129 | $238.9M | 23.9M | $215.6M | 22.7M | +1.2M+5.48% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 1.38% | 1.6% | #9 | $158.3M | 15.8M | $150.7M | 15.8M | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #118 | $151.9M | 15.2M | $116.2M | 12.2M | +3.0M+24.43% | Add |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.57% | 1.69% | #6 | $151.0M | 15.1M | $143.2M | 15.0M | +58,403+0.39% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #152 | $113.6M | 11.4M | $106.0M | 11.1M | +228,474+2.05% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #113 | $111.4M | 11.1M | $107.0M | 11.2M | -105,467-0.94% | Reduce |
| TCG Crossover Management, LLC |
| 2.65% | 3% | #1 | $110.2M | 11.0M | $104.9M | 11.0M | 00.00% | Unchanged |
| PERCEPTIVE ADVISORS LLC |
| 1.55% | 1.38% | #7 | $103.1M | 10.3M | $70.8M | 7.4M | +2.9M+38.67% | Add |
| Jupiter Topco LLC |
| 0.04% | — | #58 | $95.3M | 9.5M | $0 | 0 | +9.5M | New Buy |
| Vestal Point Capital, LP |
| 1.94% | 1.87% | #2 | $83.0M | 8.3M | $66.9M | 7.0M | +1.3M+18.15% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.05% | 0.05% | #53 | $67.8M | 6.8M | $60.9M | 6.4M | +382,721+5.99% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #132 | $62.5M | 6.2M | $55.1M | 5.8M | +465,270+8.05% | Add |
| Aberdeen Group plc |
| 0.07% | 0.08% | #44 | $53.1M | 5.3M | $48.0M | 5.0M | +270,201+5.36% | Add |
| UBS Group AG |
| 0.01% | 0.01% | #104 | $50.8M | 5.1M | $47.1M | 4.9M | +134,286+2.72% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #140 | $48.0M | 4.8M | $48.5M | 5.1M | -290,481-5.70% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #124 | $44.8M | 4.5M | $22.3M | 2.3M | +2.1M+90.93% | Add |
| Frazier Life Sciences Management, L.P. |
| 0.87% | 0.98% | #13 | $40.1M | 4.0M | $38.2M | 4.0M | 00.00% | Unchanged |
| Nuveen, LLC |
| 0.01% | 0.01% | #96 | $40.1M | 4.0M | $36.4M | 3.8M | +187,974+4.92% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #135 | $38.2M | 3.8M | $11.6M | 1.2M | +2.6M+211.97% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | <0.01% | #89 | $33.9M | 3.4M | $3.0M | 317,721 | +3.1M+968.46% | Add |
| GW&K Investment Management, LLC |
| 0.25% | 0.27% | #27 | $31.7M | 3.2M | $30.9M | 3.2M | -69,349-2.14% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | 0.01% | #115 | $27.2M | 2.7M | $25.6M | 2.7M | +28,130+1.05% | Add |
| Fisher Asset Management, LLC |
| 0.01% | 0.01% | #98 | $26.0M | 2.6M | $26.0M | 2.7M | -129,226-4.73% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.03% | 0.01% | #61 | $25.3M | 2.5M | $7.4M | 776,990 | +1.8M+225.65% | Add |
| Kynam Capital Management, LP |
| 1.39% | 3.34% | #8 | $25.2M | 2.5M | $54.1M | 5.7M | -3.2M-55.59% | Reduce |
| Candriam S.C.A. |
| 0.11% | — | #35 | $25.1M | 2.5M | $0 | 0 | +2.5M | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #138 | $23.5M | 2.4M | $22.4M | 2.4M | +2,886+0.12% | Add |
| RICE HALL JAMES & ASSOCIATES, LLC |
| 1.13% | 1.18% | #11 | $23.3M | 2.3M | $21.2M | 2.2M | +101,938+4.57% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #149 | $22.6M | 2.3M | $20.0M | 2.1M | +151,006+7.17% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| 0.01% | <0.01% | #99 | $22.1M | 2.2M | $4.2M | 440,141 | +1.8M+403.09% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #151 | $21.4M | 2.1M | $11.6M | 1.2M | +921,414+75.84% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #209 | $20.0M | 2.0M | $39.5M | 5.2M | -3.2M-61.57% | Reduce |
| Nantahala Capital Management, LLC |
| 0.63% | 0.7% | #16 | $19.0M | 1.9M | $18.9M | 2.0M | -86,237-4.34% | Reduce |
| Eversept Partners, LP |
| 0.97% | 1.53% | #12 | $18.7M | 1.9M | $28.9M | 3.0M | -1.2M-38.63% | Reduce |
| ORBIMED ADVISORS LLC |
| 0.35% | 0.27% | #23 | $18.5M | 1.9M | $13.6M | 1.4M | +426,800+29.95% | Add |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
| 0.03% | 0.02% | #67 | $18.4M | 1.8M | $11.7M | 1.2M | +617,872+50.35% | Add |
| STIFEL FINANCIAL CORP |
| 0.02% | 0.02% | #80 | $18.3M | 1.8M | $17.4M | 1.8M | +1,050+0.06% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #125 | $17.6M | 1.8M | $15.8M | 1.7M | +95,276+5.72% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #190 | $17.0M | 1.7M | $30.0M | 3.2M | -1.4M-45.91% | Reduce |
| JUPITER ASSET MANAGEMENT LTD |
| 0.08% | 0.06% | #42 | $16.4M | 1.6M | $11.4M | 1.2M | +446,503+37.32% | Add |
| IMC-Chicago, LLC |
| <0.01% | <0.01% | #123 | $16.3M | 1.6M | $6.0M | 631,290 | +1.0M+158.89% | Add |
| Parkman Healthcare Partners LLC |
| 1.66% | 1.68% | #5 | $16.2M | 1.6M | $16.3M | 1.7M | -83,820-4.91% | Reduce |
| Legal & General Group Plc |
| <0.01% | <0.01% | #141 | $14.6M | 1.5M | $13.4M | 1.4M | +44,315+3.14% | Add |
| OP Asset Management Ltd |
| 0.14% | 0.01% | #31 | $13.4M | 1.3M | $1.1M | 139,207 | +1.2M+863.31% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #216 | $12.3M | 1.2M | $12.5M | 1.3M | -75,030-5.73% | Reduce |
| Pictet Asset Management Holding SA |
| 0.01% | <0.01% | #90 | $12.0M | 1.2M | $4.5M | 471,573 | +778,198+165.02% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | 0.01% | #110 | $11.7M | 1.2M | $12.4M | 1.3M | -128,205-9.84% | Reduce |
| FIRST TRUST ADVISORS LP |
| 0.01% | 0.01% | #103 | $11.2M | 1.1M | $7.6M | 800,900 | +319,569+39.90% | Add |
| HRT FINANCIAL LP |
| 0.02% | — | #75 | $10.8M | 1.1M | $0 | 0 | +1.1M | New Buy |
| MOORE CAPITAL MANAGEMENT, LP |
| 0.13% | — | #32 | $8.5M | 848,336 | $0 | 0 | +848,336 | New Buy |
