| T. Rowe Price Investment Management, Inc. |
| 0.27% | 0.11% | #20 | $416.1M | 16.2M | $163.6M | 8.5M | +7.7M+89.91% | Add |
| BlackRock, Inc. |
| 0.01% | <0.01% | #116 | $360.8M | 14.0M | $250.3M | 13.0M | +991,979+7.61% | Add |
| BAILLIE GIFFORD & CO |
| 0.28% | 0.23% | #19 | $307.6M | 12.0M | $231.7M | 12.1M | -106,249-0.88% | Reduce |
| STATE STREET CORP |
| 0.01% | <0.01% | #115 | $181.3M | 7.0M | $120.4M | 6.3M | +777,303+12.39% | Add |
| Temasek Holdings (Private) Ltd |
| 0.48% | 0.44% | #14 | $180.4M | 7.0M | $134.6M | 7.0M | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #102 | $166.6M | 6.5M | $117.5M | 6.1M | +356,897+5.83% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #140 | $161.4M | 6.3M | $118.0M | 6.1M | +127,772+2.08% | Add |
| FMR LLC |
| 0.01% | <0.01% | #119 | $116.7M | 4.5M | $87.8M | 4.6M | -39,538-0.86% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #92 | $106.9M | 4.2M | $84.6M | 4.4M | -251,360-5.70% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #113 | $102.2M | 4.0M | $71.6M | 3.7M | +246,228+6.61% | Add |
| Holocene Advisors, LP |
| 0.23% | 0.15% | #23 | $100.4M | 3.9M | $61.4M | 3.2M | +709,796+22.21% | Add |
| BAKER BROS. ADVISORS LP |
| 0.48% | 0.41% | #15 | $96.0M | 3.7M | $71.6M | 3.7M | +2,641+0.07% | Add |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.01% | 0.02% | #77 | $81.3M | 3.2M | $85.1M | 4.4M | -1.3M-28.66% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #100 | $80.7M | 3.1M | $47.3M | 2.5M | +672,003+27.27% | Add |
| UBS Group AG |
| 0.01% | 0.01% | #88 | $80.3M | 3.1M | $49.4M | 2.6M | +549,248+21.36% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #80 | $73.6M | 2.9M | $51.7M | 2.7M | +168,429+6.26% | Add |
| NORGES BANK |
| 0.01% | 0.01% | #104 | $72.7M | 2.8M | $41.4M | 3.0M | -222,860-7.31% | Reduce |
| Pictet Asset Management Holding SA |
| 0.07% | 0.05% | #40 | $71.9M | 2.8M | $48.4M | 2.6M | +232,341+9.08% | Add |
| Capital Research Global Investors |
| 0.01% | 0.01% | #93 | $66.0M | 2.6M | $48.3M | 2.5M | +51,229+2.04% | Add |
| Fisher Asset Management, LLC |
| 0.02% | 0.02% | #72 | $62.1M | 2.4M | $46.8M | 2.4M | -22,733-0.93% | Reduce |
| ALLIANCEBERNSTEIN L.P. |
| 0.02% | 0.02% | #69 | $57.3M | 3.0M | $47.8M | 2.9M | +91,189+3.15% | Add |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.09% | <0.01% | #36 | $56.8M | 2.2M | $2.2M | 114,524 | +2.1M+1,828.21% | Add |
| Casdin Capital, LLC |
| 2.63% | 2.68% | #4 | $52.6M | 2.0M | $35.3M | 1.8M | +205,000+11.14% | Add |
| Crestline Management, L.P. |
| 91.9% | 91.74% | #1 | $49.1M | 1.9M | $42.4M | 2.2M | -300,000-13.57% | Reduce |
| PRINCIPAL FINANCIAL GROUP INC |
| 0.02% | 0.02% | #73 | $36.5M | 1.4M | $28.4M | 1.5M | -58,403-3.95% | Reduce |
| Foresite Capital Management VI LLC |
| 5.59% | 5.05% | #2 | $35.9M | 1.4M | $23.2M | 1.2M | +186,800+15.44% | Add |
| Siren, L.L.C. |
| 0.73% | 0.74% | #10 | $35.9M | 1.4M | $26.8M | 1.4M | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #128 | $35.7M | 1.4M | $25.2M | 1.3M | +79,109+6.04% | Add |
| BNP Paribas Asset Management Holding S.A. |
| 0.03% | — | #54 | $34.9M | 1.4M | $0 | 0 | +1.4M | New Buy |
| Aberdeen Group plc |
| 0.05% | 0.06% | #47 | $34.6M | 1.3M | $35.6M | 1.9M | -508,965-27.45% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #125 | $32.0M | 1.2M | $23.2M | 1.2M | +37,556+3.11% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #159 | $31.7M | 1.2M | $21.8M | 1.1M | +96,774+8.53% | Add |
| Artisan Partners Limited Partnership |
| 0.05% | 0.03% | #46 | $31.5M | 1.2M | $21.1M | 1.1M | +124,778+11.35% | Add |
| Candriam S.C.A. |
| 0.14% | 0.1% | #27 | $30.6M | 1.2M | $19.3M | 1.2M | +23,507+2.02% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #90 | $29.0M | 1.1M | $24.4M | 1.3M | -147,202-11.56% | Reduce |
| ADAR1 Capital Management, LLC |
| 1.22% | 2.12% | #7 | $26.5M | 1.0M | $35.9M | 1.9M | -842,375-45.01% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | <0.01% | #111 | $25.5M | 991,904 | $18.2M | 949,695 | +42,209+4.44% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #175 | $24.7M | 961,050 | $24.5M | 1.7M | -728,442-43.12% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #142 | $20.6M | 800,283 | $14.7M | 768,039 | +32,244+4.20% | Add |
| DAFNA Capital Management LLC |
| 3.62% | 1.39% | #3 | $19.0M | 739,014 | $6.1M | 318,500 | +420,514+132.03% | Add |
| AMERICAN CENTURY COMPANIES INC |
| 0.01% | 0.01% | #99 | $18.3M | 712,526 | $18.0M | 935,692 | -223,166-23.85% | Reduce |
| Cercano Management LLC |
| 1.4% | 0.52% | #5 | $16.1M | 625,000 | $12.0M | 625,000 | 00.00% | Unchanged |
| Nuveen, LLC |
| <0.01% | <0.01% | #136 | $15.7M | 608,967 | $5.7M | 295,586 | +313,381+106.02% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #163 | $15.4M | 600,071 | $6.7M | 351,017 | +249,054+70.95% | Add |
| Ensign Peak Advisors, Inc |
| 0.02% | 0.02% | #67 | $15.0M | 582,669 | $9.9M | 515,721 | +66,948+12.98% | Add |
| MARSHALL WACE, LLP |
| 0.01% | 0.02% | #87 | $14.1M | 549,830 | $19.0M | 991,268 | -441,438-44.53% | Reduce |
| SEGALL BRYANT & HAMILL, LLC |
| 0.16% | 0.14% | #26 | $13.4M | 519,483 | $9.8M | 510,543 | +8,940+1.75% | Add |
| CITIGROUP INC |
| <0.01% | <0.01% | #129 | $12.5M | 487,278 | $1.9M | 99,278 | +388,000+390.82% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | <0.01% | #79 | $11.1M | 432,800 | $3.7M | 195,108 | +237,692+121.83% | Add |
| Defilade Capital Management, L.P. |
| 1.35% | 3.67% | #6 | $10.1M | 391,866 | $26.1M | 1.4M | -968,103-71.19% | Reduce |
