| BlackRock, Inc. |
| <0.01% | <0.01% | #121 | $197.2M | 9.0M | $192.8M | 8.3M | +765,580+9.27% | Add |
| Kynam Capital Management, LP |
| 9.73% | 11.6% | #2 | $176.0M | 8.1M | $188.1M | 8.1M | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #84 | $128.1M | 5.9M | $116.7M | 5.0M | +864,478+17.30% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #117 | $123.7M | 5.7M | $103.5M | 4.4M | +1.2M+27.73% | Add |
| BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.01% | #104 | $88.4M | 4.0M | $99.3M | 4.2M | -204,742-4.82% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #140 | $85.9M | 3.9M | $89.3M | 3.8M | +105,313+2.76% | Add |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.86% | 1.04% | #23 | $82.6M | 3.8M | $88.3M | 3.8M | 00.00% | Unchanged |
| Eversept Partners, LP |
| 3.17% | 3.55% | #10 | $61.2M | 2.8M | $67.4M | 2.9M | -87,412-3.03% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #120 | $56.5M | 2.6M | $50.4M | 2.2M | +427,078+19.80% | Add |
| Hood River Capital Management LLC |
| 0.41% | 0.55% | #28 | $56.1M | 2.6M | $55.0M | 2.4M | +209,994+8.92% | Add |
| KINGDON CAPITAL MANAGEMENT, L.L.C. |
| 5.6% | 6.41% | #4 | $54.7M | 2.5M | $58.4M | 2.5M | 00.00% | Unchanged |
| FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #85 | $50.0M | 2.3M | $50.2M | 2.2M | +136,420+6.34% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.02% | <0.01% | #78 | $44.9M | 2.1M | $4.7M | 199,524 | +1.9M+929.43% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #138 | $42.0M | 1.9M | $40.6M | 1.7M | +184,655+10.63% | Add |
| UBS Group AG |
| 0.01% | <0.01% | #106 | $41.4M | 1.9M | $26.9M | 1.2M | +740,088+64.15% | Add |
| Elmind Capital, LP |
| 10.19% | 12.3% | #1 | $40.6M | 1.9M | $43.3M | 1.9M | 00.00% | Unchanged |
| BNP Paribas Asset Management Holding S.A. |
| 0.04% | — | #62 | $39.1M | 1.8M | $0 | 0 | +1.8M | New Buy |
| Candriam S.C.A. |
| 0.17% | 0.1% | #42 | $37.0M | 1.7M | $19.4M | 925,332 | +770,708+83.29% | Add |
| Soleus Capital Management, L.P. |
| 1.23% | 1.63% | #18 | $35.6M | 1.6M | $40.3M | 1.7M | -98,869-5.73% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| 0.02% | 0.03% | #70 | $34.5M | 1.6M | $36.9M | 1.6M | -1,471-0.09% | Reduce |
| ORBIMED ADVISORS LLC |
| 0.64% | 0.45% | #24 | $33.7M | 1.5M | $22.5M | 962,300 | +579,700+60.24% | Add |
| Nuveen, LLC |
| 0.01% | 0.01% | #94 | $29.8M | 1.4M | $34.9M | 1.5M | -130,070-8.70% | Reduce |
| MPM BioImpact LLC |
| 1.78% | 2.42% | #15 | $29.2M | 1.3M | $31.3M | 1.3M | -7,210-0.54% | Reduce |
| Aisling Capital Management LP |
| 6.1% | 6.46% | #3 | $28.8M | 1.3M | $30.8M | 1.3M | 00.00% | Unchanged |
| Woodline Partners LP |
| 0.08% | 0.11% | #51 | $27.3M | 1.3M | $29.2M | 1.3M | 00.00% | Unchanged |
| D. E. Shaw & Co., Inc. |
| 0.01% | 0.02% | #80 | $27.1M | 1.2M | $37.4M | 1.6M | -361,942-22.59% | Reduce |
| Catalio Capital Management, LP |
| 4.99% | 5.09% | #6 | $26.6M | 1.2M | $24.4M | 1.0M | +172,028+16.48% | Add |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 2.76% | 2.12% | #13 | $26.5M | 1.2M | $20.8M | 888,987 | +325,403+36.60% | Add |
| Prosight Management, LP |
| 4.52% | 2.95% | #7 | $26.2M | 1.2M | $18.0M | 770,000 | +430,000+55.84% | Add |
| Trails Edge Capital Partners, LP |
| 3.85% | 3.76% | #8 | $24.3M | 1.1M | $16.4M | 701,821 | +408,179+58.16% | Add |
| ALGERT GLOBAL LLC |
| 0.27% | 0.33% | #33 | $23.0M | 1.1M | $21.7M | 928,568 | +122,897+13.24% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #115 | $22.7M | 1.0M | $23.5M | 1.0M | +35,581+3.54% | Add |
| SPHERA FUNDS MANAGEMENT LTD. |
| 2.9% | 2.69% | #11 | $22.2M | 1.0M | $16.9M | 724,563 | +290,043+40.03% | Add |
| LOOMIS SAYLES & CO L P |
| 0.03% | — | #69 | $20.2M | 923,624 | $0 | 0 | +923,624 | New Buy |
| Parkman Healthcare Partners LLC |
| 1.96% | 2.17% | #14 | $19.2M | 877,256 | $21.1M | 901,511 | -24,255-2.69% | Reduce |
| Ensign Peak Advisors, Inc |
| 0.03% | 0.04% | #66 | $19.0M | 867,831 | $23.1M | 990,969 | -123,138-12.43% | Reduce |
| Palo Alto Investors LP |
| 2.76% | 3.09% | #12 | $18.9M | 864,986 | $20.2M | 864,986 | 00.00% | Unchanged |
| AQR CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #96 | $18.7M | 853,304 | $22.9M | 980,314 | -127,010-12.96% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #133 | $18.5M | 845,537 | $17.7M | 755,719 | +89,818+11.89% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #125 | $17.8M | 814,303 | $16.7M | 715,153 | +99,150+13.86% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #151 | $16.6M | 761,401 | $11.0M | 472,121 | +289,280+61.27% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #119 | $13.8M | 633,509 | $14.0M | 600,517 | +32,992+5.49% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #173 | $12.9M | 588,979 | $18.5M | 1.2M | -610,317-50.89% | Reduce |
| Rhenman & Partners Asset Management AB |
| 1.16% | 1.09% | #20 | $12.2M | 560,250 | $8.9M | 379,250 | +181,000+47.73% | Add |
| APIS CAPITAL ADVISORS, LLC |
| 1.18% | 1.98% | #19 | $12.2M | 556,000 | $12.8M | 550,000 | +6,000+1.09% | Add |
| PANAGORA ASSET MANAGEMENT INC |
| 0.04% | 0.02% | #63 | $11.9M | 546,517 | $5.8M | 249,407 | +297,110+119.13% | Add |
| Qube Research & Technologies Ltd |
| 0.01% | <0.01% | #87 | $10.4M | 477,182 | $842,058 | 36,047 | +441,135+1,223.78% | Add |
| FIRST TRUST ADVISORS LP |
| 0.01% | — | #103 | $10.0M | 456,700 | $0 | 0 | +456,700 | New Buy |
| Granahan Investment Management, LLC |
| 0.35% | 0.35% | #30 | $9.8M | 446,988 | $7.2M | 306,321 | +140,667+45.92% | Add |
| Knott David M Jr |
| 5.1% | 5.96% | #5 | $9.6M | 437,245 | $9.9M | 422,000 | +15,245+3.61% | Add |
