| Corvex Management LP |
| 10.03% | 8.24% | #3 | $328.5M | 4.8M | $207.3M | 3.2M | +1.6M+48.21% | Add |
| Casdin Capital, LLC |
| 12.74% | 14.62% | #1 | $254.5M | 3.7M | $193.1M | 3.0M | +700,000+23.28% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #123 | $117.1M | 1.7M | $99.6M | 1.6M | +155,531+10.03% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #75 | $114.6M | 1.7M | $85.7M | 1.3M | +334,461+25.05% | Add |
| ARK Investment Management LLC |
| 0.72% | 0.66% | #15 | $110.5M | 1.6M | $85.1M | 1.3M | +285,606+21.56% | Add |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC |
| 0.29% | 0.16% | #23 | $96.2M | 1.4M | $49.8M | 775,269 | +625,384+80.67% | Add |
| CITADEL ADVISORS LLC |
| 0.01% | 0.01% | #76 | $71.8M | 1.0M | $49.3M | 768,001 | +277,961+36.19% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #93 | $67.8M | 988,297 | $50.4M | 467,812 | +520,485+111.26% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #131 | $60.3M | 879,003 | $55.1M | 858,583 | +20,420+2.38% | Add |
| First Light Asset Management, LLC |
| 3.27% | 1.4% | #7 | $53.8M | 783,923 | $15.6M | 242,927 | +540,996+222.70% | Add |
| Deep Track Capital, LP |
| 0.7% | — | #16 | $48.1M | 700,000 | $0 | 0 | +700,000 | New Buy |
| Sumitomo Mitsui Trust Group, Inc. |
| 0.03% | 0.03% | #55 | $45.8M | 666,581 | $40.7M | 633,457 | +33,124+5.23% | Add |
| Amova Asset Management Americas, Inc. |
| 0.59% | 0.58% | #17 | $45.7M | 666,581 | $41.0M | 638,800 | +27,781+4.35% | Add |
| Zweig-DiMenna Associates LLC |
| 3.56% | 6.13% | #6 | $39.3M | 571,950 | $44.3M | 689,290 | -117,340-17.02% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #117 | $37.9M | 552,125 | $35.3M | 549,147 | +2,978+0.54% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #136 | $36.2M | 527,815 | $30.3M | 472,445 | +55,370+11.72% | Add |
| GAGNON SECURITIES LLC |
| 7.01% | 4.49% | #5 | $36.0M | 524,865 | $19.5M | 303,149 | +221,716+73.14% | Add |
| Aberdeen Group plc |
| 0.04% | 0.02% | #48 | $31.4M | 457,201 | $14.8M | 230,096 | +227,105+98.70% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #110 | $30.6M | 445,215 | $22.4M | 348,105 | +97,110+27.90% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #115 | $26.1M | 380,492 | $4.2M | 65,100 | +315,392+484.47% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #85 | $23.9M | 347,927 | $21.9M | 341,005 | +6,922+2.03% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #125 | $23.8M | 346,211 | $15.1M | 234,606 | +111,605+47.57% | Add |
| Assenagon Asset Management S.A. |
| 0.03% | 0.01% | #56 | $20.8M | 303,433 | $6.1M | 95,128 | +208,305+218.97% | Add |
| Caption Management, LLC |
| 0.09% | 0.03% | #34 | $19.9M | 289,400 | $4.5M | 69,500 | +219,900+316.40% | Add |
| FRANKLIN RESOURCES INC |
| <0.01% | 0.01% | #88 | $19.3M | 280,938 | $39.0M | 607,221 | -326,283-53.73% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #95 | $19.3M | 280,619 | $17.1M | 265,791 | +14,828+5.58% | Add |
| NORGES BANK |
| <0.01% | <0.01% | #120 | $18.7M | 273,100 | $6.0M | 68,000 | +205,100+301.62% | Add |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.25% | 0.49% | #24 | $18.5M | 269,542 | $29.5M | 459,015 | -189,473-41.28% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #121 | $14.3M | 208,663 | $3.3M | 50,825 | +157,838+310.55% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #105 | $14.3M | 207,664 | $12.6M | 195,889 | +11,775+6.01% | Add |
| Portolan Capital Management, LLC |
| 0.51% | 0.35% | #19 | $13.8M | 200,315 | $6.6M | 102,575 | +97,740+95.29% | Add |
| Point72 Asset Management, L.P. |
| 0.02% | 0.01% | #66 | $13.7M | 200,100 | $5.3M | 82,695 | +117,405+141.97% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #152 | $13.6M | 197,578 | $11.1M | 173,386 | +24,192+13.95% | Add |
| Alamea Verwaltungs GmbH |
| 10.2% | 8.85% | #2 | $12.8M | 185,989 | $11.9M | 185,989 | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #126 | $12.6M | 183,841 | $11.3M | 175,767 | +8,074+4.59% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #124 | $12.2M | 177,937 | $11.0M | 170,615 | +7,322+4.29% | Add |
| Gagnon Advisors, LLC |
| 7.76% | 7% | #4 | $12.2M | 177,870 | $9.5M | 148,225 | +29,645+20.00% | Add |
| ASHFORD CAPITAL MANAGEMENT INC |
| 1.33% | 1.38% | #10 | $11.2M | 174,512 | $11.2M | 174,512 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #91 | $10.7M | 155,575 | $9.6M | 149,906 | +5,669+3.78% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #112 | $10.5M | 152,865 | $9.3M | 144,457 | +8,408+5.82% | Add |
| Rockefeller Capital Management L.P. |
| 0.02% | 0.01% | #65 | $10.4M | 151,164 | $6.2M | 96,590 | +54,574+56.50% | Add |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
| 0.01% | — | #67 | $9.7M | 141,500 | $0 | 0 | +141,500 | New Buy |
| TUDOR INVESTMENT CORP ET AL |
| 0.01% | 0.01% | #69 | $8.5M | 124,239 | $3.3M | 51,640 | +72,599+140.59% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #87 | $8.5M | 123,690 | $495,650 | 7,718 | +115,972+1,502.62% | Add |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | 0.01% | #114 | $8.5M | 123,418 | $38.8M | 610,073 | -486,655-79.77% | Reduce |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.87% | — | #13 | $8.4M | 122,269 | $0 | 0 | +122,269 | New Buy |
| ROYCE & ASSOCIATES LP |
| 0.06% | 0.09% | #43 | $7.7M | 112,136 | $9.0M | 140,513 | -28,377-20.20% | Reduce |
| FRED ALGER MANAGEMENT, LLC |
| 0.02% | 0.06% | #57 | $7.5M | 108,527 | $13.0M | 202,771 | -94,244-46.48% | Reduce |
| Science & Technology Partners, L.P. |
| 1.23% | 4.05% | #11 | $7.3M | 106,387 | $15.5M | 241,200 | -134,813-55.89% | Reduce |
| THRIVENT FINANCIAL FOR LUTHERANS |
| 0.01% | 0.02% | #73 | $7.0M | 101,992 | $9.9M | 153,721 | -51,729-33.65% | Reduce |
