| FMR LLC |
| 0.03% | 0.03% | #63 | $592.7M | 15.8M | $572.4M | 15.8M | +80,420+0.51% | Add |
| BlackRock, Inc. |
| 0.01% | 0.01% | #92 | $365.2M | 9.8M | $308.0M | 8.5M | +1.3M+15.10% | Add |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 1.55% | 1.73% | #9 | $336.4M | 9.0M | $302.8M | 8.3M | +651,000+7.81% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.05% | 0.06% | #53 | $266.8M | 7.1M | $296.3M | 8.2M | -1.0M-12.58% | Reduce |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 1.4% | 1.71% | #10 | $241.9M | 6.5M | $232.3M | 6.4M | +67,629+1.06% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.02% | #64 | $232.5M | 6.2M | $194.5M | 5.4M | +857,185+16.01% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #83 | $180.8M | 4.8M | $168.5M | 4.6M | +194,103+4.18% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #105 | $177.6M | 4.7M | $169.8M | 4.7M | +71,327+1.53% | Add |
| Jupiter Topco LLC |
| 0.07% | — | #43 | $170.5M | 4.6M | $0 | 0 | +4.6M | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #91 | $102.1M | 2.7M | $90.1M | 2.5M | +246,870+9.95% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #120 | $100.6M | 2.7M | $87.3M | 2.4M | +286,304+11.91% | Add |
| Bellevue Group AG |
| 2.06% | 2.84% | #6 | $98.0M | 2.6M | $119.1M | 3.3M | -660,000-20.12% | Reduce |
| BAKER BROS. ADVISORS LP |
| 0.44% | 0.49% | #21 | $88.0M | 2.4M | $85.4M | 2.4M | 00.00% | Unchanged |
| Polar Capital Holdings Plc |
| 0.2% | — | #33 | $85.1M | 2.3M | $0 | 0 | +2.3M | New Buy |
| Pictet Asset Management Holding SA |
| 0.07% | 0.07% | #42 | $77.6M | 2.1M | $68.2M | 1.9M | +191,094+10.14% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.05% | 0.05% | #50 | $75.2M | 2.0M | $70.5M | 1.9M | +69,666+3.59% | Add |
| GW&K Investment Management, LLC |
| 0.51% | 0.52% | #19 | $64.8M | 1.7M | $58.8M | 1.6M | +112,454+6.95% | Add |
| BNP Paribas Asset Management Holding S.A. |
| 0.06% | — | #45 | $62.8M | 1.7M | $0 | 0 | +1.7M | New Buy |
| Siren, L.L.C. |
| 1.08% | 1.92% | #13 | $53.2M | 1.4M | $69.1M | 1.9M | -482,848-25.36% | Reduce |
| First Light Asset Management, LLC |
| 3.1% | 3.55% | #2 | $50.9M | 1.4M | $39.6M | 1.1M | +271,196+24.89% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #123 | $50.6M | 1.4M | $45.4M | 1.3M | +40,362+3.05% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #126 | $50.1M | 1.3M | $28.4M | 682,134 | +656,397+96.23% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #117 | $49.9M | 1.3M | $26.0M | 716,125 | +616,946+86.15% | Add |
| Novo Holdings A/S |
| 2.88% | 4.56% | #3 | $49.4M | 1.3M | $56.3M | 1.6M | -230,000-14.84% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #78 | $47.5M | 1.3M | $30.9M | 852,258 | +418,273+49.08% | Add |
| AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.02% | #66 | $47.2M | 1.3M | $38.2M | 1.1M | +209,704+19.92% | Add |
| ADAR1 Capital Management, LLC |
| 2.11% | 2.44% | #5 | $45.7M | 1.2M | $41.4M | 1.1M | +82,749+7.26% | Add |
| MONTANOVA CAPITAL, LLC |
| 0.81% | 0.97% | #16 | $44.4M | 1.2M | $37.9M | 1.0M | +142,400+13.64% | Add |
| MARSHALL WACE, LLP |
| 0.03% | 0.02% | #58 | $42.2M | 1.1M | $24.8M | 684,108 | +442,531+64.69% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #113 | $41.3M | 1.1M | $22.8M | 628,155 | +476,843+75.91% | Add |
| ORBIMED ADVISORS LLC |
| 0.71% | 0.72% | #17 | $37.4M | 999,000 | $36.3M | 999,000 | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #100 | $36.5M | 974,781 | $30.6M | 841,301 | +133,480+15.87% | Add |
| Hood River Capital Management LLC |
| 0.26% | 0.33% | #29 | $36.3M | 968,996 | $33.0M | 907,412 | +61,584+6.79% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #99 | $32.8M | 877,643 | $30.3M | 833,418 | +44,225+5.31% | Add |
| Aberdeen Group plc |
| 0.04% | 0.05% | #54 | $30.7M | 820,395 | $29.8M | 820,395 | 00.00% | Unchanged |
| Candriam S.C.A. |
| 0.14% | 0.19% | #34 | $30.6M | 819,032 | $38.7M | 830,961 | -11,929-1.44% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #86 | $28.2M | 754,436 | $25.7M | 708,473 | +45,963+6.49% | Add |
| Fisher Asset Management, LLC |
| 0.01% | 0.01% | #82 | $27.7M | 741,553 | $27.7M | 762,702 | -21,149-2.77% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #125 | $21.0M | 561,165 | $20.8M | 571,899 | -10,734-1.88% | Reduce |
| Nuveen, LLC |
| <0.01% | 0.01% | #95 | $20.8M | 555,381 | $20.0M | 551,464 | +3,917+0.71% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | 0.01% | #107 | $18.6M | 497,205 | $29.0M | 798,334 | -301,129-37.72% | Reduce |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
| 0.01% | 0.01% | #72 | $17.7M | 480,504 | $13.1M | 382,363 | +98,141+25.67% | Add |
| Impax Asset Management Group plc |
| 0.11% | 0.09% | #38 | $16.3M | 435,000 | $12.7M | 350,000 | +85,000+24.29% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #128 | $14.7M | 393,688 | $13.0M | 358,719 | +34,969+9.75% | Add |
| Prosight Management, LP |
| 2.42% | 2.08% | #4 | $14.0M | 374,666 | $12.7M | 350,000 | +24,666+7.05% | Add |
| Universal- Beteiligungs- und Servicegesellschaft mbH |
| 0.02% | 0.02% | #65 | $14.0M | 373,910 | $15.5M | 425,616 | -51,706-12.15% | Reduce |
| KENNEDY CAPITAL MANAGEMENT LLC |
| 0.24% | — | #30 | $13.7M | 365,714 | $0 | 0 | +365,714 | New Buy |
| BRAUN STACEY ASSOCIATES INC |
| 0.37% | 0.39% | #22 | $13.0M | 348,143 | $11.8M | 324,808 | +23,335+7.18% | Add |
| Fiera Capital Corp |
| 0.05% | 0.07% | #52 | $12.7M | 338,841 | $21.4M | 589,654 | -250,813-42.54% | Reduce |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #119 | $10.6M | 283,727 | $9.4M | 257,525 | +26,202+10.17% | Add |
