| FMR LLC |
| 0.02% | 0.02% | #75 | $445.8M | 7.0M | $328.6M | 6.8M | +147,661+2.16% | Add |
| Rubric Capital Management LP |
| 2.35% | 1.91% | #3 | $255.8M | 4.0M | $180.6M | 3.8M | +249,800+6.66% | Add |
| BAKER BROS. ADVISORS LP |
| 0.91% | 0.78% | #9 | $181.3M | 2.8M | $136.1M | 2.8M | +8,397+0.30% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #141 | $175.2M | 2.7M | $23.4M | 486,737 | +2.3M+462.85% | Add |
| TANG CAPITAL MANAGEMENT LLC |
| 6.56% | 5.53% | #2 | $144.5M | 2.3M | $108.8M | 2.3M | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | <0.01% | #116 | $122.2M | 1.9M | $85.0M | 1.8M | +145,067+8.21% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #157 | $87.0M | 1.4M | $64.2M | 1.3M | +27,747+2.08% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #127 | $64.7M | 1.0M | $52.9M | 1.4M | -351,780-25.81% | Reduce |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.03% | 0.02% | #64 | $61.2M | 957,514 | $43.0M | 892,666 | +64,848+7.26% | Add |
| Spruce Street Capital LP |
| 11.52% | 8.81% | #1 | $58.7M | 918,070 | $36.6M | 761,063 | +157,007+20.63% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #92 | $55.9M | 874,786 | $39.1M | 811,922 | +62,864+7.74% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #124 | $49.4M | 772,806 | $1.3M | 27,656 | +745,150+2,694.35% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.27% | 0.22% | #28 | $45.9M | 718,199 | $29.4M | 611,398 | +106,801+17.47% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #175 | $45.0M | 704,194 | $3.7M | 76,633 | +627,561+818.92% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.05% | 0.09% | #50 | $43.4M | 679,083 | $64.3M | 1.3M | -657,230-49.18% | Reduce |
| Point72 Asset Management, L.P. |
| 0.05% | 0.04% | #52 | $42.2M | 659,493 | $30.9M | 640,958 | +18,535+2.89% | Add |
| RICE HALL JAMES & ASSOCIATES, LLC |
| 1.95% | 1.63% | #5 | $40.0M | 624,928 | $29.3M | 608,416 | +16,512+2.71% | Add |
| Pictet Asset Management Holding SA |
| 0.04% | 0.03% | #58 | $38.9M | 608,650 | $30.0M | 623,288 | -14,638-2.35% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #151 | $38.6M | 604,180 | $2.1M | 44,320 | +559,860+1,263.22% | Add |
| Jupiter Topco LLC |
| 0.02% | — | #82 | $37.5M | 586,177 | $0 | 0 | +586,177 | New Buy |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.07% | 0.07% | #43 | $36.6M | 572,598 | $31.3M | 649,629 | -77,031-11.86% | Reduce |
| D. E. Shaw & Co., Inc. |
| 0.02% | 0.03% | #79 | $36.4M | 569,756 | $46.2M | 959,257 | -389,501-40.60% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| 0.03% | 0.02% | #65 | $35.9M | 561,480 | $20.3M | 420,914 | +140,566+33.40% | Add |
| VICTORY CAPITAL MANAGEMENT INC |
| 0.02% | 0.02% | #77 | $32.3M | 504,853 | $24.4M | 506,521 | -1,668-0.33% | Reduce |
| SG Americas Securities, LLC |
| 0.02% | 0.03% | #81 | $32.2M | 504,001 | $30.8M | 640,179 | -136,178-21.27% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | 0.02% | #87 | $28.0M | 437,192 | $31.2M | 647,731 | -210,539-32.50% | Reduce |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | 0.01% | #98 | $27.6M | 431,324 | $21.1M | 438,002 | -6,678-1.52% | Reduce |
| ORBIMED ADVISORS LLC |
| 0.51% | 0.17% | #16 | $26.9M | 420,600 | $8.7M | 180,599 | +240,001+132.89% | Add |
| ALLIANCEBERNSTEIN L.P. |
| 0.01% | 0.01% | #97 | $26.8M | 556,151 | $24.7M | 598,888 | -42,737-7.14% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #161 | $26.4M | 413,411 | $35.4M | 735,940 | -322,529-43.83% | Reduce |
| OBERWEIS ASSET MANAGEMENT INC/ |
| 0.55% | 0.45% | #13 | $26.4M | 413,034 | $15.3M | 318,634 | +94,400+29.63% | Add |
| Aberdeen Group plc |
| 0.04% | 0.03% | #59 | $25.8M | 403,485 | $18.0M | 373,634 | +29,851+7.99% | Add |
| Fisher Asset Management, LLC |
| 0.01% | 0.01% | #104 | $25.5M | 398,266 | $20.7M | 428,972 | -30,706-7.16% | Reduce |
| DEUTSCHE BANK AG\ |
| 0.01% | 0.01% | #105 | $24.8M | 387,606 | $25.2M | 523,691 | -136,085-25.99% | Reduce |
| AQR CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #102 | $24.0M | 375,039 | $18.2M | 378,697 | -3,658-0.97% | Reduce |
| Penn Capital Management Company, LLC |
| 1.49% | 1.13% | #7 | $23.6M | 368,114 | $14.6M | 301,993 | +66,121+21.89% | Add |
| Caption Management, LLC |
| 0.1% | 0.28% | #37 | $20.8M | 324,800 | $48.1M | 999,400 | -674,600-67.50% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #146 | $20.2M | 315,246 | $1.8M | 36,924 | +278,322+753.77% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.03% | #67 | $19.8M | 309,682 | $24.1M | 499,792 | -190,110-38.04% | Reduce |
| Qube Research & Technologies Ltd |
| 0.02% | 0.04% | #78 | $19.4M | 304,080 | $33.1M | 686,853 | -382,773-55.73% | Reduce |
| NEW YORK STATE COMMON RETIREMENT FUND |
| 0.02% | 0.01% | #69 | $17.4M | 272,579 | $10.1M | 209,617 | +62,962+30.04% | Add |
| NOMURA HOLDINGS INC |
| 0.02% | 0.04% | #70 | $17.3M | 270,724 | $16.5M | 342,939 | -72,215-21.06% | Reduce |
| Soleus Capital Management, L.P. |
| 0.54% | 1.02% | #15 | $15.8M | 246,353 | $25.1M | 521,353 | -275,000-52.75% | Reduce |
| ESSEX INVESTMENT MANAGEMENT CO LLC |
| 2.02% | 1.9% | #4 | $15.4M | 241,382 | $12.0M | 249,278 | -7,896-3.17% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #145 | $14.9M | 232,531 | $837,226 | 17,388 | +215,143+1,237.31% | Add |
| ArrowMark Colorado Holdings LLC |
| 0.57% | 0.41% | #12 | $13.8M | 215,546 | $15.3M | 316,956 | -101,410-31.99% | Reduce |
| STEMPOINT CAPITAL LP |
| 1.91% | — | #6 | $13.4M | 209,234 | $0 | 0 | +209,234 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #178 | $12.2M | 191,364 | $8.4M | 174,901 | +16,463+9.41% | Add |
| SEI INVESTMENTS CO |
| 0.01% | 0.01% | #90 | $12.1M | 188,565 | $13.7M | 284,005 | -95,440-33.61% | Reduce |
| BRAIDWELL LP |
| 0.43% | 0.44% | #18 | $11.8M | 183,822 | $13.1M | 272,522 | -88,700-32.55% | Reduce |
