| FMR LLC |
| 0.02% | 0.03% | #48 | $551.1M | 30.9M | $550.4M | 30.8M | +138,293+0.45% | Add |
| J. H. Whitney Equity Partners VI, LLC |
| 100% | 100% | #1 | $200.6M | 11.3M | $326.4M | 18.3M | -7.0M-38.34% | Reduce |
| COATUE MANAGEMENT LLC |
| 0.36% | 0.6% | #14 | $175.0M | 9.8M | $175.6M | 9.8M | 00.00% | Unchanged |
| BRAIDWELL LP |
| 5.44% | 4.78% | #3 | $147.1M | 8.3M | $143.2M | 8.0M | +246,585+3.08% | Add |
| Sixth Street Partners Management Company, L.P. |
| 22.54% | 36.19% | #2 | $130.6M | 7.3M | $257.2M | 14.4M | -7.1M-49.07% | Reduce |
| PointState Capital LP |
| 1.56% | 1.67% | #5 | $121.7M | 6.8M | $131.6M | 7.4M | -531,611-7.22% | Reduce |
| JPMORGAN CHASE & CO |
| 0.01% | <0.01% | #84 | $120.2M | 6.6M | $58.3M | 3.5M | +3.1M+89.54% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #134 | $98.7M | 5.5M | $86.8M | 4.9M | +679,686+13.99% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.06% | 0.07% | #30 | $90.5M | 5.1M | $99.9M | 5.6M | -509,116-9.11% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #101 | $86.3M | 4.8M | $67.2M | 3.8M | +1.1M+28.89% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #131 | $76.3M | 4.3M | $59.5M | 3.3M | +951,217+28.57% | Add |
| LOS ANGELES CAPITAL MANAGEMENT LLC |
| 0.26% | 0.16% | #16 | $70.5M | 4.0M | $40.9M | 2.3M | +1.7M+72.89% | Add |
| Neuberger Berman Group LLC |
| 0.04% | 0.05% | #37 | $64.0M | 3.6M | $64.2M | 3.6M | +377+0.01% | Add |
| ORBIMED ADVISORS LLC |
| 0.94% | 0.99% | #7 | $50.0M | 2.8M | $50.2M | 2.8M | 00.00% | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.02% | 0.01% | #53 | $42.2M | 2.4M | $28.9M | 1.6M | +755,982+46.83% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #65 | $39.3M | 2.2M | $27.3M | 1.5M | +674,891+44.18% | Add |
| MAK CAPITAL ONE LLC |
| 4.84% | — | #4 | $34.5M | 1.9M | $0 | 0 | +1.9M | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #128 | $34.5M | 1.9M | $46.4M | 1.5M | +401,108+26.14% | Add |
| Duquesne Family Office LLC |
| 0.65% | 1% | #10 | $33.8M | 1.9M | $33.9M | 1.9M | 00.00% | Unchanged |
| Clearbridge Investments, LLC |
| 0.02% | 0.02% | #49 | $28.4M | 1.6M | $27.7M | 1.6M | +44,103+2.84% | Add |
| FIL Ltd |
| 0.02% | 0.02% | #54 | $27.6M | 1.5M | $27.6M | 1.5M | +2,827+0.18% | Add |
| UBS Group AG |
| <0.01% | 0.01% | #107 | $25.4M | 1.4M | $49.1M | 2.7M | -1.3M-48.16% | Reduce |
| HRT FINANCIAL LP |
| 0.05% | — | #35 | $25.3M | 1.4M | $0 | 0 | +1.4M | New Buy |
| CANADA PENSION PLAN INVESTMENT BOARD |
| 0.01% | 0.02% | #63 | $24.5M | 1.4M | $23.7M | 1.3M | +52,200+3.95% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #160 | $21.7M | 1.2M | $17.6M | 984,953 | +232,595+23.61% | Add |
| Amundi |
| 0.01% | <0.01% | #89 | $21.7M | 1.2M | $374,979 | 20,972 | +1.2M+5,709.48% | Add |
| Capital World Investors |
| <0.01% | <0.01% | #113 | $21.6M | 1.2M | $21.1M | 1.2M | +33,099+2.80% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | 0.01% | #120 | $21.5M | 1.2M | $78.2M | 4.4M | -3.2M-72.43% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #139 | $21.4M | 1.2M | $9.4M | 523,268 | +677,322+129.44% | Add |
| Champlain Investment Partners, LLC |
| 0.48% | 0.27% | #12 | $18.7M | 1.0M | $21.6M | 1.2M | -159,101-13.17% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #148 | $18.6M | 1.0M | $13.9M | 778,532 | +266,125+34.18% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #133 | $17.0M | 951,942 | $7.3M | 410,340 | +541,602+131.99% | Add |
| ZEVENBERGEN CAPITAL INVESTMENTS LLC |
| 0.33% | 0.31% | #15 | $14.3M | 802,083 | $10.9M | 610,233 | +191,850+31.44% | Add |
| SEI INVESTMENTS CO |
| 0.01% | 0.01% | #70 | $13.6M | 762,659 | $10.7M | 598,712 | +163,947+27.38% | Add |
| Trexquant Investment LP |
| 0.08% | 0.06% | #27 | $13.0M | 727,944 | $8.8M | 490,536 | +237,408+48.40% | Add |
| Woodline Partners LP |
| 0.04% | 0.05% | #38 | $12.9M | 723,163 | $12.9M | 723,163 | 00.00% | Unchanged |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.01% | <0.01% | #91 | $11.7M | 655,644 | $3.8M | 210,593 | +445,051+211.33% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #112 | $10.8M | 604,416 | $11.9M | 663,578 | -59,162-8.92% | Reduce |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #122 | $10.2M | 572,784 | $7.3M | 408,079 | +164,705+40.36% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #154 | $10.2M | 570,932 | $5.8M | 322,766 | +248,166+76.89% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #61 | $10.1M | 568,000 | $8.0M | 449,900 | +118,100+26.25% | Add |
| Rock Springs Capital Management LP |
| 0.42% | 0.59% | #13 | $8.7M | 487,500 | $10.1M | 563,000 | -75,500-13.41% | Reduce |
| Quantinno Capital Management LP |
| 0.01% | <0.01% | #74 | $7.9M | 441,672 | $2.5M | 140,909 | +300,763+213.44% | Add |
| Walleye Capital LLC |
| 0.03% | — | #45 | $7.6M | 424,407 | $0 | 0 | +424,407 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #153 | $7.0M | 394,655 | $2.3M | 129,910 | +264,745+203.79% | Add |
| Squarepoint Ops LLC |
| 0.01% | — | #79 | $6.8M | 380,927 | $0 | 0 | +380,927 | New Buy |
| TD ASSET MANAGEMENT INC |
| 0.01% | 0.01% | #86 | $6.8M | 379,388 | $12.0M | 670,388 | -291,000-43.41% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #150 | $5.5M | 308,407 | $4.1M | 231,661 | +76,746+33.13% | Add |
| FEDERATED HERMES, INC. |
| 0.01% | 0.01% | #80 | $5.1M | 285,598 | $4.3M | 239,150 | +46,448+19.42% | Add |
| PICTON MAHONEY ASSET MANAGEMENT |
| 0.03% | 0.04% | #39 | $4.7M | 264,064 | $5.0M | 278,977 | -14,913-5.35% | Reduce |
