| BlackRock, Inc. |
| 0.01% | 0.01% | #116 | $434.9M | 9.4M | $454.7M | 8.8M | +552,792+6.28% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.06% | 0.07% | #54 | $179.2M | 3.9M | $171.4M | 3.3M | +537,239+16.20% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #111 | $153.7M | 3.3M | $167.4M | 3.2M | +66,736+2.06% | Add |
| ARMISTICE CAPITAL, LLC |
| 1.51% | 1.74% | #6 | $123.1M | 2.6M | $98.0M | 1.9M | +750,854+39.62% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #174 | $117.1M | 2.5M | $127.5M | 2.5M | +49,506+2.01% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #147 | $114.4M | 2.5M | $118.3M | 2.3M | +171,701+7.50% | Add |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.17% | 0.18% | #23 | $110.6M | 2.4M | $105.3M | 2.0M | +341,127+16.74% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.02% | 0.02% | #79 | $96.7M | 2.1M | $119.2M | 2.3M | -228,940-9.92% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | 0.01% | #141 | $73.0M | 1.6M | $83.9M | 1.6M | -53,426-3.29% | Reduce |
| Stephens Investment Management Group LLC |
| 0.74% | 0.96% | #12 | $69.1M | 1.5M | $69.9M | 1.4M | +134,490+9.95% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.09% | 0.14% | #37 | $68.8M | 1.5M | $88.1M | 1.7M | -227,042-13.31% | Reduce |
| LOOMIS SAYLES & CO L P |
| 0.09% | 0.1% | #43 | $68.6M | 1.5M | $73.7M | 1.4M | +49,413+3.47% | Add |
| CITADEL ADVISORS LLC |
| 0.01% | 0.01% | #106 | $66.0M | 1.4M | $79.0M | 1.5M | -108,564-7.10% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| 0.04% | 0.01% | #61 | $55.1M | 1.2M | $14.0M | 271,228 | +913,150+336.67% | Add |
| GW&K Investment Management, LLC |
| 0.38% | 0.48% | #18 | $48.2M | 1.0M | $54.5M | 1.1M | -17,942-1.70% | Reduce |
| Sofinnova Investments, Inc. |
| 2.49% | 1.87% | #3 | $48.2M | 1.0M | $49.3M | 954,309 | +82,019+8.59% | Add |
| Qube Research & Technologies Ltd |
| 0.04% | 0.03% | #62 | $42.9M | 922,166 | $25.8M | 498,198 | +423,968+85.10% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #177 | $40.8M | 876,841 | $36.1M | 755,317 | +121,524+16.09% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | 0.01% | #148 | $38.1M | 819,432 | $44.3M | 856,487 | -37,055-4.33% | Reduce |
| D. E. Shaw & Co., Inc. |
| 0.02% | 0.02% | #80 | $35.7M | 767,668 | $32.2M | 622,450 | +145,218+23.33% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #139 | $34.1M | 733,374 | $36.2M | 699,456 | +33,918+4.85% | Add |
| ASHFORD CAPITAL MANAGEMENT INC |
| 3.95% | 4.12% | #2 | $33.4M | 645,381 | $33.4M | 645,381 | 00.00% | Unchanged |
| Woodline Partners LP |
| 0.1% | 0.09% | #34 | $32.9M | 708,276 | $23.2M | 448,996 | +259,280+57.75% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | 0.01% | #130 | $32.7M | 703,552 | $36.5M | 705,976 | -2,424-0.34% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #181 | $28.9M | 621,102 | $36.9M | 714,226 | -93,124-13.04% | Reduce |
| Soleus Capital Management, L.P. |
| 0.83% | — | #9 | $24.2M | 520,000 | $0 | 0 | +520,000 | New Buy |
| RICE HALL JAMES & ASSOCIATES, LLC |
| 1.11% | 1.37% | #8 | $22.8M | 490,221 | $24.7M | 477,416 | +12,805+2.68% | Add |
| SYSTEMATIC FINANCIAL MANAGEMENT LP |
| 0.44% | 0.45% | #16 | $22.1M | 474,131 | $19.4M | 376,079 | +98,052+26.07% | Add |
| Aberdeen Group plc |
| 0.03% | 0.02% | #70 | $21.1M | 453,206 | $14.2M | 275,561 | +177,645+64.47% | Add |
| Pictet Asset Management Holding SA |
| 0.02% | 0.02% | #77 | $20.2M | 432,478 | $22.3M | 450,764 | -18,286-4.06% | Reduce |
| Invesco Ltd. |
| <0.01% | <0.01% | #194 | $18.4M | 395,101 | $21.3M | 412,683 | -17,582-4.26% | Reduce |
| VICTORY CAPITAL MANAGEMENT INC |
| 0.01% | 0.02% | #96 | $18.2M | 391,075 | $26.0M | 502,406 | -111,331-22.16% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #140 | $17.9M | 384,828 | $19.1M | 369,247 | +15,581+4.22% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #163 | $17.6M | 377,402 | $18.7M | 362,408 | +14,994+4.14% | Add |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
| 0.01% | 0.01% | #89 | $17.2M | 368,017 | $8.7M | 176,076 | +191,941+109.01% | Add |
| PRINCIPAL FINANCIAL GROUP INC |
| 0.01% | 0.01% | #104 | $16.2M | 348,461 | $17.6M | 341,117 | +7,344+2.15% | Add |
| Freestone Grove Partners LP |
| 0.09% | 0.23% | #38 | $14.7M | 316,398 | $33.1M | 641,319 | -324,921-50.66% | Reduce |
| FMR LLC |
| <0.01% | <0.01% | #230 | $14.4M | 309,091 | $10.8M | 209,370 | +99,721+47.63% | Add |
| Krensavage Asset Management, LLC |
| 4.96% | 5.67% | #1 | $13.1M | 280,681 | $14.5M | 280,681 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #224 | $12.9M | 272,329 | $12.4M | 250,735 | +21,594+8.61% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #161 | $12.2M | 262,675 | $11.2M | 216,047 | +46,628+21.58% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #200 | $10.3M | 220,457 | $10.8M | 209,124 | +11,333+5.42% | Add |
| GLENMEDE TRUST CO NA |
| 0.04% | 0.06% | #60 | $9.8M | 210,952 | $11.3M | 219,099 | -8,147-3.72% | Reduce |
| PUBLIC SECTOR PENSION INVESTMENT BOARD |
| 0.02% | 0.03% | #74 | $9.3M | 199,351 | $10.6M | 205,158 | -5,807-2.83% | Reduce |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC |
| 0.08% | — | #47 | $8.5M | 182,909 | $0 | 0 | +182,909 | New Buy |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #189 | $8.0M | 171,529 | $9.0M | 173,905 | -2,376-1.37% | Reduce |
| Aristotle Capital Boston, LLC |
| 0.53% | 0.65% | #15 | $7.9M | 169,686 | $10.5M | 203,094 | -33,408-16.45% | Reduce |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #150 | $7.4M | 160,129 | $8.3M | 161,025 | -896-0.56% | Reduce |
| Man Group plc |
| 0.01% | 0.01% | #91 | $7.3M | 156,422 | $3.9M | 74,992 | +81,430+108.58% | Add |
| THIRD AVENUE MANAGEMENT LLC |
| 1.14% | 1.28% | #7 | $7.1M | 152,724 | $7.9M | 152,724 | 00.00% | Unchanged |
