| Paradigm Biocapital Advisors LP |
| 6.76% | 4.37% | #2 | $360.8M | 13.1M | $213.8M | 8.0M | +5.2M+64.83% | Add |
| Orbis Allan Gray Ltd |
| 1.07% | 1.46% | #9 | $312.3M | 11.4M | $346.8M | 12.9M | -1.6M-12.05% | Reduce |
| Deep Track Capital, LP |
| 3.46% | 1.61% | #4 | $237.6M | 8.7M | $98.3M | 3.7M | +5.0M+136.13% | Add |
| ALLIANCEBERNSTEIN L.P. |
| 0.08% | 0.1% | #28 | $231.9M | 8.6M | $294.4M | 9.6M | -912,272-9.55% | Reduce |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.97% | 0.78% | #6 | $188.6M | 6.9M | $66.1M | 2.5M | +4.4M+178.84% | Add |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.06% | 0.07% | #32 | $136.7M | 5.0M | $133.5M | 5.0M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #153 | $128.3M | 4.7M | $121.7M | 4.5M | +134,687+2.97% | Add |
| Sofinnova Investments, Inc. |
| 5.74% | 0.77% | #3 | $111.1M | 4.0M | $20.2M | 752,261 | +3.3M+437.74% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.13% | 0.19% | #22 | $96.6M | 3.5M | $118.4M | 4.4M | -896,700-20.31% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| 0.07% | 0.05% | #30 | $96.3M | 3.5M | $62.8M | 2.3M | +1.2M+49.90% | Add |
| HARDING LOEVNER LP |
| 0.82% | 0.89% | #10 | $86.9M | 3.1M | $86.7M | 3.2M | -145,283-4.50% | Reduce |
| CITADEL ADVISORS LLC |
| 0.01% | <0.01% | #85 | $77.8M | 2.8M | $4.6M | 172,500 | +2.7M+1,542.66% | Add |
| FIRST TRUST ADVISORS LP |
| 0.04% | 0.05% | #39 | $75.7M | 2.8M | $66.0M | 2.5M | +295,180+11.99% | Add |
| Qube Research & Technologies Ltd |
| 0.04% | 0.02% | #40 | $46.4M | 1.7M | $18.2M | 677,346 | +1.0M+149.40% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #144 | $44.8M | 1.6M | $51.4M | 1.7M | -44,413-2.65% | Reduce |
| FEDERATED HERMES, INC. |
| 0.06% | 0.05% | #33 | $39.8M | 1.4M | $33.6M | 1.3M | +197,786+15.80% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #131 | $35.1M | 1.3M | $25.0M | 931,259 | +347,972+37.37% | Add |
| FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #98 | $33.0M | 1.2M | $32.0M | 1.2M | +9,778+0.82% | Add |
| Pictet Asset Management Holding SA |
| 0.03% | 0.03% | #48 | $29.3M | 1.1M | $28.9M | 1.1M | -11,544-1.07% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #127 | $26.4M | 961,053 | $8.0M | 298,132 | +662,921+222.36% | Add |
| Perpetual Ltd |
| 0.37% | 0.31% | #14 | $25.2M | 919,048 | $20.4M | 758,503 | +160,545+21.17% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #134 | $25.2M | 916,600 | $25.5M | 950,534 | -33,934-3.57% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #87 | $25.0M | 910,604 | $21.3M | 792,293 | +118,311+14.93% | Add |
| Caption Management, LLC |
| 0.11% | — | #24 | $24.7M | 897,774 | $0 | 0 | +897,774 | New Buy |
| Russell Investments Group, Ltd. |
| 0.02% | 0.02% | #54 | $24.3M | 883,430 | $21.4M | 797,068 | +86,362+10.83% | Add |
| ENVESTNET ASSET MANAGEMENT INC |
| 0.01% | 0.01% | #106 | $22.8M | 829,687 | $23.1M | 862,301 | -32,614-3.78% | Reduce |
| MARSHALL WACE, LLP |
| 0.02% | <0.01% | #58 | $22.8M | 829,659 | $402,450 | 15,000 | +814,659+5,431.06% | Add |
| Alyeska Investment Group, L.P. |
| 0.06% | 0.05% | #34 | $22.1M | 804,374 | $17.3M | 645,481 | +158,893+24.62% | Add |
| FMR LLC |
| <0.01% | <0.01% | #182 | $21.0M | 764,694 | $27.1M | 1.0M | -247,032-24.42% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #175 | $19.4M | 744,815 | $5.7M | 222,607 | +522,208+234.59% | Add |
| AMERICAN CENTURY COMPANIES INC |
| 0.01% | 0.01% | #94 | $16.5M | 599,953 | $14.5M | 538,944 | +61,009+11.32% | Add |
| CIBC WORLD MARKET INC. |
| 0.02% | 0.02% | #51 | $14.1M | 514,764 | $13.1M | 488,266 | +26,498+5.43% | Add |
| OPPENHEIMER ASSET MANAGEMENT INC. |
| 0.13% | 0.14% | #23 | $12.3M | 447,426 | $12.3M | 457,508 | -10,082-2.20% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #179 | $12.0M | 437,043 | $5.8M | 214,332 | +222,711+103.91% | Add |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 7.46% | 3.77% | #1 | $11.8M | 430,600 | $5.3M | 196,709 | +233,891+118.90% | Add |
| MOORE CAPITAL MANAGEMENT, LP |
| 0.17% | 0.12% | #21 | $11.6M | 420,487 | $5.7M | 211,705 | +208,782+98.62% | Add |
| Dixon Mitchell Investment Counsel Inc. |
| 0.37% | — | #13 | $11.4M | 416,000 | $0 | 0 | +416,000 | New Buy |
| Quantinno Capital Management LP |
| 0.01% | 0.01% | #75 | $9.2M | 333,388 | $7.6M | 282,498 | +50,890+18.01% | Add |
| Hudson Bay Capital Management LP |
| 0.02% | 0.03% | #49 | $9.1M | 330,000 | $8.3M | 310,000 | +20,000+6.45% | Add |
| SummitTX Capital, L.P. |
| 0.23% | 0.07% | #16 | $8.7M | 318,408 | $2.3M | 84,354 | +234,054+277.47% | Add |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #164 | $8.3M | 303,639 | $8.6M | 319,592 | -15,953-4.99% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #194 | $7.9M | 288,465 | $2.9M | 106,800 | +181,665+170.10% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #209 | $7.1M | 259,249 | $6.5M | 241,520 | +17,729+7.34% | Add |
| EAGLE GLOBAL ADVISORS LLC |
| 0.22% | 0.24% | #17 | $6.7M | 244,730 | $6.6M | 244,565 | +165+0.07% | Add |
| ASSETMARK, INC |
| 0.01% | 0.01% | #73 | $6.6M | 238,803 | $6.0M | 224,144 | +14,659+6.54% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #132 | $6.3M | 227,990 | $6.1M | 227,587 | +403+0.18% | Add |
| FOLKETRYGDFONDET |
| 0.1% | 0.08% | #26 | $4.5M | 165,082 | $4.3M | 160,773 | +4,309+2.68% | Add |
| Tidal Investments LLC |
| 0.01% | 0.01% | #91 | $4.5M | 162,384 | $4.9M | 184,124 | -21,740-11.81% | Reduce |
| AIMZ Investment Advisors, LLC |
| 1.22% | 1.33% | #7 | $4.4M | 160,910 | $4.3M | 160,910 | 00.00% | Unchanged |
| LPL Financial LLC |
| <0.01% | <0.01% | #183 | $4.0M | 144,321 | $5.1M | 188,637 | -44,316-23.49% | Reduce |
