| VIKING GLOBAL INVESTORS LP |
| 1.83% | 1.16% | #3 | $643.4M | 30.0M | $416.3M | 30.0M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #134 | $324.7M | 15.1M | $184.6M | 13.3M | +1.8M+13.80% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #168 | $137.4M | 6.4M | $84.6M | 6.1M | +309,443+5.08% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.02% | 0.01% | #83 | $126.8M | 5.9M | $53.5M | 3.9M | +2.1M+53.25% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | <0.01% | #128 | $117.5M | 5.5M | $62.3M | 4.5M | +984,757+21.93% | Add |
| D. E. Shaw & Co., Inc. |
| 0.05% | 0.02% | #58 | $99.2M | 4.6M | $27.3M | 2.0M | +2.7M+135.34% | Add |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.3% | 0.32% | #20 | $91.5M | 4.3M | $75.5M | 5.4M | -1.2M-21.50% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #147 | $78.1M | 3.6M | $50.5M | 3.6M | +5,783+0.16% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #182 | $74.2M | 3.5M | $44.8M | 3.2M | +231,143+7.16% | Add |
| UBS Group AG |
| 0.01% | <0.01% | #112 | $67.2M | 3.1M | $3.1M | 225,986 | +2.9M+1,285.29% | Add |
| Invesco Ltd. |
| 0.01% | 0.01% | #131 | $66.4M | 3.1M | $61.8M | 4.5M | -1.4M-30.47% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #127 | $64.0M | 3.0M | $45.0M | 3.2M | -257,850-7.95% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #124 | $57.2M | 2.7M | $21.7M | 1.6M | +1.1M+70.18% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.31% | 0.18% | #19 | $54.2M | 2.5M | $24.3M | 1.8M | +777,102+44.39% | Add |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.02% | 0.01% | #78 | $54.2M | 2.5M | $27.7M | 2.0M | +529,418+26.53% | Add |
| LORD, ABBETT & CO. LLC |
| 0.15% | 0.16% | #33 | $53.1M | 2.5M | $49.1M | 3.5M | -1.1M-30.01% | Reduce |
| Nuveen, LLC |
| 0.01% | <0.01% | #93 | $50.8M | 2.4M | $18.1M | 1.3M | +1.1M+81.43% | Add |
| BNP Paribas Asset Management Holding S.A. |
| 0.05% | — | #59 | $46.8M | 2.2M | $0 | 0 | +2.2M | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #156 | $46.5M | 2.2M | $2.8M | 202,317 | +2.0M+971.87% | Add |
| FRED ALGER MANAGEMENT, LLC |
| 0.15% | 0.13% | #34 | $44.9M | 2.1M | $28.6M | 2.1M | +29,138+1.41% | Add |
| ARK Investment Management LLC |
| 0.29% | 0.23% | #21 | $44.8M | 2.1M | $29.1M | 2.1M | -2,663-0.13% | Reduce |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.06% | 0.04% | #47 | $40.5M | 1.9M | $26.1M | 1.9M | +8,005+0.43% | Add |
| Aristotle Atlantic Partners, LLC |
| 1.64% | 1.11% | #4 | $39.4M | 1.8M | $23.8M | 1.7M | +124,167+7.24% | Add |
| TORONTO DOMINION BANK |
| 0.04% | — | #60 | $38.6M | 1.8M | $0 | 0 | +1.8M | New Buy |
| T. Rowe Price Investment Management, Inc. |
| 0.03% | 0.01% | #77 | $38.2M | 1.8M | $12.8M | 919,278 | +860,373+93.59% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #178 | $37.1M | 1.7M | $17.0M | 1.2M | +502,127+40.89% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #169 | $35.3M | 1.6M | $9.9M | 710,682 | +934,031+131.43% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #152 | $32.3M | 1.5M | $19.3M | 1.4M | +115,019+8.26% | Add |
| Sumitomo Mitsui Trust Group, Inc. |
| 0.02% | 0.01% | #90 | $28.5M | 1.3M | $22.1M | 1.6M | -265,514-16.64% | Reduce |
| Amova Asset Management Americas, Inc. |
| 0.37% | 0.31% | #15 | $28.5M | 1.3M | $22.1M | 1.6M | -265,514-16.64% | Reduce |
| OBERWEIS ASSET MANAGEMENT INC/ |
| 0.56% | 0.33% | #11 | $27.0M | 1.3M | $11.2M | 806,951 | +451,800+55.99% | Add |
| PERCEPTIVE ADVISORS LLC |
| 0.39% | 0.04% | #14 | $26.1M | 1.2M | $2.1M | 152,500 | +1.1M+698.25% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #161 | $25.3M | 1.2M | $15.9M | 1.1M | +32,870+2.87% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | 0.01% | #135 | $23.3M | 1.1M | $41.9M | 3.0M | -1.9M-63.95% | Reduce |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | 0.01% | #118 | $23.0M | 1.1M | $14.9M | 1.1M | -396-0.04% | Reduce |
| Blue Water Life Science Advisors, LP |
| 13.65% | 11.24% | #1 | $21.7M | 1.0M | $14.0M | 1.0M | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #140 | $20.0M | 934,709 | $12.1M | 870,959 | +63,750+7.32% | Add |
| Aberdeen Group plc |
| 0.03% | 0.02% | #76 | $19.7M | 918,998 | $14.9M | 1.1M | -151,629-14.16% | Reduce |
| Freestone Grove Partners LP |
| 0.12% | — | #37 | $18.9M | 881,688 | $0 | 0 | +881,688 | New Buy |
| KENNEDY CAPITAL MANAGEMENT LLC |
| 0.32% | 0.27% | #18 | $18.2M | 849,795 | $12.9M | 931,522 | -81,727-8.77% | Reduce |
| HRT FINANCIAL LP |
| 0.03% | <0.01% | #72 | $17.1M | 795,168 | $1.8M | 131,241 | +663,927+505.88% | Add |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.03% | 0.02% | #70 | $16.9M | 785,903 | $9.0M | 649,627 | +136,276+20.98% | Add |
| PANAGORA ASSET MANAGEMENT INC |
| 0.05% | 0.03% | #56 | $16.7M | 777,615 | $7.2M | 515,926 | +261,689+50.72% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #214 | $16.4M | 766,230 | $16.0M | 1.1M | -305,840-28.53% | Reduce |
| Granite Investment Partners, LLC |
| 0.83% | 0.43% | #9 | $16.2M | 757,217 | $6.9M | 500,061 | +257,156+51.42% | Add |
| Trexquant Investment LP |
| 0.09% | 0.06% | #41 | $15.8M | 736,260 | $7.9M | 571,584 | +164,676+28.81% | Add |
| FMR LLC |
| <0.01% | <0.01% | #230 | $15.2M | 709,534 | $7.9M | 567,032 | +142,502+25.13% | Add |
| JENNISON ASSOCIATES LLC |
| 0.01% | 0.01% | #109 | $14.7M | 686,195 | $10.5M | 753,073 | -66,878-8.88% | Reduce |
| Hillsdale Investment Management Inc. |
| 0.33% | 0.24% | #16 | $14.7M | 684,217 | $8.7M | 625,217 | +59,000+9.44% | Add |
| NEXT CENTURY GROWTH INVESTORS LLC |
| 0.69% | 0.52% | #10 | $13.1M | 609,830 | $7.0M | 504,346 | +105,484+20.92% | Add |
