| BlackRock, Inc. |
| <0.01% | <0.01% | #121 | $242.7M | 3.9M | $249.2M | 3.6M | +303,525+8.54% | Add |
| Deep Track Capital, LP |
| 3.36% | 4.12% | #2 | $230.8M | 3.7M | $252.5M | 3.6M | +66,768+1.85% | Add |
| RTW INVESTMENTS, LP |
| 1.8% | 2.34% | #5 | $211.3M | 3.4M | $234.7M | 3.3M | +11,034+0.33% | Add |
| Jupiter Topco LLC |
| 0.07% | — | #40 | $176.8M | 2.8M | $0 | 0 | +2.8M | New Buy |
| Paradigm Biocapital Advisors LP |
| 3.27% | 3.67% | #3 | $174.7M | 2.8M | $179.7M | 2.6M | +213,495+8.33% | Add |
| MORGAN STANLEY |
| 0.01% | 0.01% | #93 | $115.0M | 1.8M | $113.7M | 1.9M | -85,320-4.46% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #136 | $112.9M | 1.8M | $123.5M | 1.8M | +32,523+1.85% | Add |
| JENNISON ASSOCIATES LLC |
| 0.06% | 0.08% | #44 | $104.7M | 1.7M | $120.1M | 1.7M | -48,469-2.83% | Reduce |
| TANG CAPITAL MANAGEMENT LLC |
| 4.48% | 4.23% | #1 | $98.7M | 1.6M | $83.4M | 1.2M | +379,642+31.94% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.03% | 0.02% | #58 | $91.7M | 1.5M | $41.7M | 594,579 | +862,545+145.07% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | 0.01% | #102 | $75.1M | 1.2M | $83.8M | 1.2M | -1,195-0.10% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #116 | $69.6M | 1.1M | $78.7M | 1.1M | -15,402-1.37% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #141 | $67.5M | 1.1M | $68.6M | 978,212 | +94,739+9.68% | Add |
| Vestal Point Capital, LP |
| 1.54% | 0.39% | #6 | $66.1M | 1.1M | $14.0M | 200,000 | +850,000+425.00% | Add |
| Assenagon Asset Management S.A. |
| 0.07% | 0.14% | #39 | $59.6M | 947,495 | $89.8M | 1.3M | -332,699-25.99% | Reduce |
| Invesco Ltd. |
| <0.01% | 0.01% | #112 | $49.5M | 785,808 | $52.1M | 742,497 | +43,311+5.83% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #110 | $46.7M | 742,693 | $30.8M | 439,626 | +303,067+68.94% | Add |
| Frazier Life Sciences Management, L.P. |
| 1% | 1.32% | #10 | $45.9M | 728,644 | $51.1M | 728,644 | 00.00% | Unchanged |
| D. E. Shaw & Co., Inc. |
| 0.02% | 0.03% | #69 | $44.7M | 710,559 | $55.5M | 791,146 | -80,587-10.19% | Reduce |
| FMR LLC |
| <0.01% | <0.01% | #145 | $42.4M | 672,949 | $51.4M | 733,334 | -60,385-8.23% | Reduce |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.06% | 0.06% | #46 | $38.2M | 607,272 | $35.1M | 499,853 | +107,419+21.49% | Add |
| TORONTO DOMINION BANK |
| 0.04% | 0.05% | #56 | $35.1M | 557,253 | $35.8M | 510,253 | +47,000+9.21% | Add |
| Clearbridge Investments, LLC |
| 0.03% | 0.03% | #60 | $34.6M | 549,387 | $38.3M | 545,351 | +4,036+0.74% | Add |
| Caption Management, LLC |
| 0.16% | 0.1% | #28 | $33.4M | 530,700 | $16.6M | 236,448 | +294,252+124.45% | Add |
| LORD, ABBETT & CO. LLC |
| 0.09% | 0.19% | #36 | $30.2M | 479,266 | $59.1M | 842,313 | -363,047-43.10% | Reduce |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | — | #82 | $26.9M | 427,008 | $0 | 0 | +427,008 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #128 | $24.3M | 386,611 | $24.8M | 352,957 | +33,654+9.53% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #168 | $24.2M | 385,137 | $23.6M | 335,889 | +49,248+14.66% | Add |
| LOOMIS SAYLES & CO L P |
| 0.03% | 0.04% | #59 | $24.0M | 380,684 | $28.6M | 407,836 | -27,152-6.66% | Reduce |
| TimesSquare Capital Management, LLC |
| 0.34% | 0.46% | #16 | $23.2M | 369,377 | $27.3M | 388,590 | -19,213-4.94% | Reduce |
| WASATCH ADVISORS LP |
| 0.15% | — | #29 | $23.2M | 368,568 | $0 | 0 | +368,568 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #129 | $21.1M | 335,834 | $23.0M | 328,162 | +7,672+2.34% | Add |
| Tri Locum Partners LP |
| 2.54% | 2.49% | #4 | $20.7M | 328,340 | $17.7M | 252,588 | +75,752+29.99% | Add |
| MPM BioImpact LLC |
| 1.24% | 1.79% | #9 | $20.3M | 322,007 | $23.1M | 329,750 | -7,743-2.35% | Reduce |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.12% | 0.48% | #31 | $20.0M | 317,576 | $65.0M | 926,125 | -608,549-65.71% | Reduce |
| Squarepoint Ops LLC |
| 0.02% | 0.02% | #70 | $18.6M | 295,824 | $16.9M | 241,033 | +54,791+22.73% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #111 | $18.0M | 286,289 | $19.1M | 272,743 | +13,546+4.97% | Add |
| FRANKLIN RESOURCES INC |
| <0.01% | 0.01% | #117 | $18.0M | 286,008 | $23.4M | 333,676 | -47,668-14.29% | Reduce |
| Artisan Partners Limited Partnership |
| 0.03% | 0.03% | #62 | $17.9M | 284,899 | $21.6M | 307,307 | -22,408-7.29% | Reduce |
| Rock Springs Capital Management LP |
| 0.85% | 0.93% | #13 | $17.4M | 277,087 | $15.8M | 225,179 | +51,908+23.05% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #142 | $17.3M | 274,137 | $12.8M | 183,097 | +91,040+49.72% | Add |
| Ensign Peak Advisors, Inc |
| 0.03% | 0.04% | #63 | $16.9M | 268,696 | $23.4M | 332,982 | -64,286-19.31% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #158 | $16.8M | 266,790 | $3.9M | 56,035 | +210,755+376.11% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #147 | $16.4M | 260,784 | $19.3M | 274,804 | -14,020-5.10% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | 0.01% | #94 | $12.7M | 201,624 | $21.3M | 303,509 | -101,885-33.57% | Reduce |
| MACKENZIE FINANCIAL CORP |
| 0.01% | — | #78 | $12.0M | 191,428 | $0 | 0 | +191,428 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #172 | $12.0M | 190,100 | $13.5M | 192,000 | -1,900-0.99% | Reduce |
| Parkman Healthcare Partners LLC |
| 0.97% | — | #11 | $9.4M | 150,000 | $0 | 0 | +150,000 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #192 | $8.7M | 139,981 | $2.0M | 30,478 | +109,503+359.29% | Add |
| Allspring Global Investments Holdings, LLC |
| 0.01% | 0.02% | #76 | $7.9M | 130,329 | $9.2M | 131,612 | -1,283-0.97% | Reduce |
