| MONTANOVA CAPITAL, LLC |
| 5.96% | 7.42% | #3 | $326.1M | 12.4M | $290.4M | 12.3M | +110,000+0.89% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #134 | $276.5M | 10.5M | $216.8M | 9.2M | +1.3M+14.62% | Add |
| Frazier Life Sciences Management, L.P. |
| 5.64% | 5.99% | #4 | $258.9M | 9.9M | $232.6M | 9.9M | 00.00% | Unchanged |
| Rubric Capital Management LP |
| 1.99% | 2.06% | #5 | $216.9M | 8.3M | $194.9M | 8.3M | 00.00% | Unchanged |
| Polar Capital Holdings Plc |
| 0.41% | 0.47% | #19 | $173.2M | 6.6M | $133.5M | 5.7M | +940,005+16.59% | Add |
| STATE STREET CORP |
| <0.01% | 0.01% | #126 | $152.7M | 5.8M | $148.3M | 6.3M | -473,357-7.52% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #155 | $130.8M | 5.0M | $114.8M | 4.9M | +117,220+2.41% | Add |
| MORGAN STANLEY |
| 0.01% | <0.01% | #113 | $116.7M | 4.5M | $80.6M | 4.3M | +174,620+4.08% | Add |
| JENNISON ASSOCIATES LLC |
| 0.07% | 0.08% | #46 | $110.6M | 4.2M | $117.3M | 5.0M | -761,712-15.29% | Reduce |
| D. E. Shaw & Co., Inc. |
| 0.05% | 0.04% | #53 | $103.6M | 3.9M | $58.8M | 2.5M | +1.5M+58.22% | Add |
| UBS Group AG |
| 0.01% | 0.01% | #93 | $87.4M | 3.3M | $78.4M | 3.3M | +3,791+0.11% | Add |
| BANK OF AMERICA CORP /DE/ |
| 0.01% | <0.01% | #119 | $78.3M | 3.0M | $52.3M | 2.2M | +766,142+34.49% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #132 | $78.2M | 3.0M | $71.8M | 3.0M | -62,860-2.06% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #154 | $63.7M | 2.4M | $46.1M | 2.0M | +474,320+24.27% | Add |
| ORBIMED ADVISORS LLC |
| 1.01% | — | #11 | $53.5M | 2.0M | $0 | 0 | +2.0M | New Buy |
| FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #97 | $50.6M | 1.9M | $54.1M | 2.3M | -366,961-15.97% | Reduce |
| AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.02% | #72 | $50.5M | 1.9M | $34.5M | 1.5M | +461,803+31.56% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #138 | $43.7M | 1.7M | $37.8M | 1.6M | +65,354+4.08% | Add |
| Jupiter Topco LLC |
| 0.02% | — | #82 | $37.0M | 1.4M | $0 | 0 | +1.4M | New Buy |
| OBERWEIS ASSET MANAGEMENT INC/ |
| 0.74% | 0.95% | #14 | $36.0M | 1.4M | $32.2M | 1.4M | +7,000+0.51% | Add |
| GILDER GAGNON HOWE & CO LLC |
| 0.36% | 1.22% | #21 | $34.4M | 1.3M | $101.4M | 4.3M | -3.0M-69.49% | Reduce |
| GW&K Investment Management, LLC |
| 0.26% | 0.21% | #24 | $33.8M | 1.3M | $23.3M | 988,387 | +299,631+30.32% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #137 | $33.3M | 1.3M | $2.3M | 98,206 | +1.2M+1,191.79% | Add |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 10.78% | 11.42% | #1 | $33.2M | 1.3M | $31.9M | 1.4M | -90,609-6.68% | Reduce |
| BAMCO INC /NY/ |
| 0.05% | 0.08% | #52 | $32.9M | 1.3M | $25.3M | 1.1M | +180,931+16.87% | Add |
| FEDERATED HERMES, INC. |
| 0.04% | 0.04% | #55 | $29.5M | 1.1M | $25.4M | 1.1M | +47,362+4.40% | Add |
| Perpetual Ltd |
| 0.42% | 0.33% | #18 | $29.1M | 1.1M | $21.4M | 909,546 | +200,111+22.00% | Add |
| Aberdeen Group plc |
| 0.04% | 0.02% | #58 | $28.8M | 1.1M | $15.2M | 645,066 | +453,345+70.28% | Add |
| Jones Hill Capital LP |
| 6.07% | — | #2 | $28.6M | 1.1M | $0 | 0 | +1.1M | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #146 | $27.8M | 1.1M | $23.0M | 976,512 | +82,063+8.40% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #140 | $27.6M | 1.1M | $23.9M | 1.0M | +38,379+3.79% | Add |
| Ensign Peak Advisors, Inc |
| 0.04% | 0.05% | #56 | $25.6M | 974,534 | $29.3M | 1.2M | -269,853-21.69% | Reduce |
| Candriam S.C.A. |
| 0.11% | 0.12% | #36 | $24.9M | 949,839 | $23.3M | 803,138 | +146,701+18.27% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.13% | 0.39% | #35 | $23.0M | 878,426 | $52.4M | 2.2M | -1.3M-60.54% | Reduce |
| Nuveen, LLC |
| 0.01% | 0.01% | #117 | $21.9M | 834,261 | $21.3M | 902,134 | -67,873-7.52% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #125 | $21.4M | 815,138 | $18.2M | 771,764 | +43,374+5.62% | Add |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| 0.02% | 0.01% | #76 | $21.3M | 811,752 | $11.9M | 503,856 | +307,896+61.11% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #88 | $17.4M | 663,877 | $5.5M | 234,307 | +429,570+183.34% | Add |
| FISHMAN JAY A LTD/MI |
| 1.24% | 1.19% | #9 | $15.6M | 595,005 | $13.4M | 566,730 | +28,275+4.99% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #183 | $15.0M | 570,615 | $6.3M | 265,779 | +304,836+114.70% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #120 | $14.8M | 564,072 | $1.2M | 49,333 | +514,739+1,043.40% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | 0.01% | #109 | $14.3M | 547,278 | $19.1M | 812,146 | -264,868-32.61% | Reduce |
| Squarepoint Ops LLC |
| 0.02% | 0.03% | #78 | $14.1M | 537,747 | $26.0M | 1.1M | -565,743-51.27% | Reduce |
| CAPITOLIS LIQUID GLOBAL MARKETS LLC |
| 0.06% | 0.07% | #47 | $13.1M | 500,000 | $11.8M | 500,000 | 00.00% | Unchanged |
| Nearwater Capital Markets, Ltd |
| 0.22% | 0.34% | #29 | $12.8M | 486,700 | $14.3M | 607,300 | -120,600-19.86% | Reduce |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | 0.01% | #75 | $12.2M | 466,000 | $8.6M | 366,000 | +100,000+27.32% | Add |
| MARSHALL WACE, LLP |
| 0.01% | 0.06% | #100 | $11.7M | 446,866 | $57.3M | 2.4M | -2.0M-81.62% | Reduce |
| Privium Fund Management B.V. |
| 1.92% | 1.57% | #6 | $10.5M | 399,367 | $7.6M | 320,972 | +78,395+24.42% | Add |
| NORGES BANK |
| <0.01% | <0.01% | #188 | $10.3M | 392,300 | $10.6M | 679,320 | -287,020-42.25% | Reduce |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #153 | $10.0M | 382,682 | $9.2M | 389,847 | -7,165-1.84% | Reduce |
