| BVF INC/IL |
| 1.21% | 1.74% | #1 | $47.2M | 19.8M | $54.5M | 19.8M | 00.00% | Unchanged |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #14 | $2.4M | 1.0M | $2.8M | 1.0M | -243-0.02% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #4 | $2.0M | 840,127 | $1.7M | 624,367 | +215,760+34.56% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #10 | $1.8M | 773,594 | $2.2M | 792,657 | -19,063-2.40% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #29 | $1.2M | 519,274 | $1.4M | 524,278 | -5,004-0.95% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #20 | $812,145 | 340,082 | $1.1M | 390,165 | -50,083-12.84% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #22 | $603,107 | 253,406 | $820,141 | 298,233 | -44,827-15.03% | Reduce |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | <0.01% | #16 | $554,428 | 232,953 | $1.1M | 405,658 | -172,705-42.57% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #27 | $378,584 | 159,069 | $433,846 | 157,762 | +1,307+0.83% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #30 | $313,720 | 131,815 | $265,975 | 92,033 | +39,782+43.23% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #19 | $244,723 | 102,825 | $107,500 | 39,091 | +63,734+163.04% | Add |
| Qube Research & Technologies Ltd |
| <0.01% | — | #18 | $219,795 | 92,351 | $0 | 0 | +92,351 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #28 | $203,762 | 85,614 | $279,480 | 101,629 | -16,015-15.76% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #34 | $147,212 | 61,854 | $174,902 | 63,601 | -1,747-2.75% | Reduce |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #25 | $73,304 | 30,800 | $18,205 | 6,620 | +24,180+365.26% | Add |
| Jump Financial, LLC |
| <0.01% | <0.01% | #11 | $57,272 | 24,064 | $30,594 | 11,125 | +12,939+116.31% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #35 | $46,350 | 19,475 | $158,664 | 57,696 | -38,221-66.25% | Reduce |
| Verdad Advisers, LP |
| 0.04% | — | #2 | $38,794 | 16,300 | $0 | 0 | +16,300 | New Buy |
| China Universal Asset Management Co., Ltd. |
| <0.01% | <0.01% | #6 | $38,549 | 16,197 | $49,093 | 17,852 | -1,655-9.27% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #40 | $34,503 | 14,497 | $59,488 | 21,632 | -7,135-32.98% | Reduce |
| Quadrature Capital Ltd |
| <0.01% | — | #15 | $30,919 | 12,991 | $0 | 0 | +12,991 | New Buy |
| GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #26 | $26,180 | 11,000 | $495,275 | 180,100 | -169,100-93.89% | Reduce |
| AXQ CAPITAL, LP |
| <0.01% | — | #5 | $24,747 | 10,398 | $0 | 0 | +10,398 | New Buy |
| SG Americas Securities, LLC |
| <0.01% | — | #32 | $24,578 | 10,327 | $0 | 0 | +10,327 | New Buy |
| Quinn Opportunity Partners LLC |
| <0.01% | <0.01% | #8 | $24,038 | 10,100 | $27,775 | 10,100 | 00.00% | Unchanged |
| Silverberg Bernstein Capital Management LLC |
| 0.01% | 0.02% | #3 | $23,800 | 10,000 | $27,500 | 10,000 | 00.00% | Unchanged |
| EFG International AG |
| <0.01% | <0.01% | #13 | $23,562 | 9,900 | $27,225 | 9,900 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #42 | $20,743 | 7,798 | $19,558 | 7,640 | +158+2.07% | Add |
| BARCLAYS PLC |
| <0.01% | <0.01% | #37 | $17,322 | 7,278 | $15,926 | 5,791 | +1,487+25.68% | Add |
| Banque Cantonale Vaudoise |
| <0.01% | <0.01% | #9 | $17,000 | 7,021 | $19,000 | 7,021 | 00.00% | Unchanged |
| Mirae Asset Global Investments Co., Ltd. |
| <0.01% | <0.01% | #31 | $10,834 | 4,552 | $14,429 | 5,247 | -695-13.25% | Reduce |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #17 | $9,760 | 4,101 | $19,275 | 7,009 | -2,908-41.49% | Reduce |
| CITIGROUP INC |
| <0.01% | <0.01% | #38 | $9,549 | 4,012 | $7,730 | 2,811 | +1,201+42.73% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #39 | $6,424 | 2,699 | $6,628 | 2,410 | +289+11.99% | Add |
| GF FUND MANAGEMENT CO. LTD. |
| <0.01% | <0.01% | #24 | $4,960 | 2,084 | $6,166 | 2,242 | -158-7.05% | Reduce |
| Forum Finance Group S.A. |
| <0.01% | <0.01% | #7 | $4,760 | 2,000 | $5,500 | 2,000 | 00.00% | Unchanged |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #45 | $3,000 | 1,289 | $2,000 | 760 | +529+69.61% | Add |
| SBI Securities Co., Ltd. |
| <0.01% | — | #23 | $2,849 | 1,197 | $0 | 0 | +1,197 | New Buy |
| PNC FINANCIAL SERVICES GROUP, INC. |
| <0.01% | <0.01% | #41 | $2,380 | 1,000 | $2,750 | 1,000 | 00.00% | Unchanged |
| Rockefeller Capital Management L.P. |
| <0.01% | <0.01% | #36 | $2,380 | 1,000 | $2,750 | 1,000 | 00.00% | Unchanged |
| Activest Wealth Management |
| <0.01% | <0.01% | #12 | $2,380 | 1,000 | $2,750 | 1,000 | 00.00% | Unchanged |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #44 | $523 | 220 | $607 | 221 | -1-0.45% | Reduce |
| Strengthening Families & Communities, LLC |
| <0.01% | <0.01% | #21 | $476 | 200 | $550 | 200 | 00.00% | Unchanged |
| Farther Finance Advisors, LLC |
| <0.01% | <0.01% | #43 | $102 | 43 | $120 | 43 | 00.00% | Unchanged |
| Caitong International Asset Management Co., Ltd |
| <0.01% | <0.01% | #33 | $83 | 35 | $8 | 3 | +32+1,066.67% | Add |
