| FMR LLC |
| 0.02% | 0.02% | #83 | $419.2M | 7.8M | $405.0M | 8.4M | -593,143-7.06% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.07% | 0.07% | #62 | $396.1M | 7.4M | $349.9M | 7.3M | +119,146+1.64% | Add |
| Avoro Capital Advisors LLC |
| 3.16% | 3.11% | #6 | $351.8M | 6.6M | $316.0M | 6.6M | 00.00% | Unchanged |
| Jupiter Topco LLC |
| 0.11% | — | #53 | $279.3M | 5.2M | $0 | 0 | +5.2M | New Buy |
| Deep Track Capital, LP |
| 3.7% | 3.37% | #4 | $254.4M | 4.7M | $206.3M | 4.3M | +460,224+10.75% | Add |
| BVF INC/IL |
| 4.62% | 5.31% | #2 | $180.7M | 3.4M | $166.7M | 3.5M | -92,535-2.67% | Reduce |
| MORGAN STANLEY |
| 0.01% | <0.01% | #96 | $150.6M | 2.8M | $16.2M | 577,741 | +2.2M+385.80% | Add |
| ORBIMED ADVISORS LLC |
| 2.24% | 1.41% | #10 | $118.6M | 2.2M | $71.1M | 1.5M | +733,997+49.75% | Add |
| PRINCIPAL FINANCIAL GROUP INC |
| 0.05% | 0.05% | #68 | $94.1M | 1.8M | $84.5M | 1.8M | -1,011-0.06% | Reduce |
| AMERICAN CENTURY COMPANIES INC |
| 0.04% | 0.04% | #70 | $90.3M | 1.7M | $69.3M | 1.4M | +244,148+16.98% | Add |
| RTW INVESTMENTS, LP |
| 0.74% | — | #21 | $86.3M | 1.6M | $0 | 0 | +1.6M | New Buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.48% | 0.56% | #28 | $83.4M | 1.6M | $76.0M | 1.6M | -24,137-1.53% | Reduce |
| BAKER BROS. ADVISORS LP |
| 0.39% | 0.4% | #33 | $76.9M | 1.4M | $69.0M | 1.4M | 00.00% | Unchanged |
| Casdin Capital, LLC |
| 3.16% | 4.29% | #7 | $63.1M | 1.2M | $56.6M | 1.2M | 00.00% | Unchanged |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.61% | 0.44% | #24 | $58.3M | 1.1M | $37.0M | 767,993 | +318,007+41.41% | Add |
| CAPITOLIS LIQUID GLOBAL MARKETS LLC |
| 0.24% | 0.35% | #40 | $55.9M | 1.0M | $55.5M | 1.2M | -110,200-9.57% | Reduce |
| Siren, L.L.C. |
| 0.95% | 1.78% | #19 | $46.9M | 872,967 | $64.0M | 1.3M | -455,731-34.30% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | 0.01% | #109 | $45.4M | 845,532 | $96.4M | 2.0M | -1.2M-57.74% | Reduce |
| PACIFIC HEIGHTS ASSET MANAGEMENT LLC |
| 1.36% | 1.21% | #14 | $42.9M | 800,000 | $36.2M | 750,000 | +50,000+6.67% | Add |
| Rock Springs Capital Management LP |
| 1.68% | 1.82% | #11 | $34.4M | 640,317 | $30.9M | 640,217 | +100+0.02% | Add |
| Aberdeen Group plc |
| 0.05% | 0.03% | #67 | $34.3M | 639,915 | $18.9M | 391,809 | +248,106+63.32% | Add |
| FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #100 | $31.1M | 578,839 | $25.6M | 531,595 | +47,244+8.89% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #129 | $30.2M | 563,422 | $10.9M | 227,132 | +336,290+148.06% | Add |
| ALLIANCEBERNSTEIN L.P. |
| 0.01% | 0.01% | #93 | $29.5M | 611,708 | $44.4M | 638,813 | -27,105-4.24% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #160 | $27.4M | 511,149 | $21.3M | 441,975 | +69,174+15.65% | Add |
| Logos Global Management LP |
| 1.16% | 1.2% | #18 | $26.8M | 500,000 | $24.1M | 500,000 | 00.00% | Unchanged |
| Parkman Healthcare Partners LLC |
| 2.67% | 1.15% | #9 | $26.1M | 485,661 | $11.2M | 232,093 | +253,568+109.25% | Add |
| Davern Capital Partners, LP |
| 4.08% | 1.67% | #3 | $23.9M | 446,059 | $6.1M | 126,461 | +319,598+252.72% | Add |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
| 0.03% | 0.04% | #74 | $22.5M | 418,800 | $22.5M | 467,800 | -49,000-10.47% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #131 | $20.8M | 387,790 | $20.9M | 434,043 | -46,253-10.66% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #122 | $20.3M | 378,986 | $10.3M | 212,919 | +166,067+78.00% | Add |
| DEUTSCHE BANK AG\ |
| 0.01% | 0.01% | #106 | $17.8M | 331,867 | $16.0M | 331,867 | 00.00% | Unchanged |
| NEXTBio Capital Management LP |
| 7.71% | 2.98% | #1 | $16.8M | 312,496 | $6.4M | 133,239 | +179,257+134.54% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #138 | $15.7M | 293,244 | $18.3M | 380,042 | -86,798-22.84% | Reduce |
| Catalio Capital Management, LP |
| 2.79% | 2.57% | #8 | $14.8M | 276,550 | $12.3M | 255,379 | +21,171+8.29% | Add |
| MARSHALL WACE, LLP |
| 0.01% | <0.01% | #89 | $14.4M | 267,592 | $3.3M | 69,107 | +198,485+287.21% | Add |
| HSG Holding Ltd |
| 1.19% | 0.38% | #16 | $14.3M | 266,062 | $6.2M | 266,062 | 00.00% | Unchanged |
| SEB Asset Management AB |
| 0.05% | 0.05% | #66 | $13.2M | 245,043 | $11.8M | 245,043 | 00.00% | Unchanged |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #125 | $12.4M | 230,514 | $10.6M | 219,516 | +10,998+5.01% | Add |
| NATIONAL BANK OF CANADA /FI/ |
| 0.01% | 0.01% | #92 | $11.6M | 215,800 | $14.7M | 305,400 | -89,600-29.34% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #97 | $11.0M | 204,156 | $8.7M | 181,415 | +22,741+12.54% | Add |
| Eversept Partners, LP |
| 0.55% | 0.35% | #27 | $10.5M | 196,302 | $6.7M | 138,036 | +58,266+42.21% | Add |
| Schonfeld Strategic Advisors LLC |
| 0.04% | 0.06% | #73 | $10.2M | 190,685 | $8.0M | 165,426 | +25,259+15.27% | Add |
| Woodline Partners LP |
| 0.03% | 0.03% | #78 | $8.3M | 153,808 | $9.2M | 190,808 | -37,000-19.39% | Reduce |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.01% | 0.01% | #88 | $8.2M | 153,119 | $6.5M | 134,015 | +19,104+14.26% | Add |
| ArrowMark Colorado Holdings LLC |
| 0.34% | 0.24% | #35 | $8.1M | 150,579 | $9.1M | 188,195 | -37,616-19.99% | Reduce |
| Susquehanna Portfolio Strategies, LLC |
| 0.13% | 0.04% | #51 | $8.0M | 148,948 | $2.9M | 60,517 | +88,431+146.13% | Add |
| CenterBook Partners LP |
| 0.39% | 0.05% | #32 | $7.9M | 148,030 | $1.0M | 21,237 | +126,793+597.04% | Add |
| Rhenman & Partners Asset Management AB |
| 0.74% | 0.76% | #22 | $7.8M | 145,100 | $6.2M | 128,100 | +17,000+13.27% | Add |
| B Group, Inc. |
| 3.53% | 4.56% | #5 | $7.5M | 140,000 | $6.1M | 127,500 | +12,500+9.80% | Add |
