| RTW INVESTMENTS, LP |
| 5.16% | 4.7% | #9 | $605.0M | 8.5M | $472.7M | 7.0M | +1.5M+21.90% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.31% | 0.31% | #25 | $470.1M | 6.6M | $454.8M | 6.7M | -103,490-1.54% | Reduce |
| Decheng Capital LLC |
| 61.87% | 65.21% | #1 | $452.7M | 6.4M | $431.2M | 6.4M | 00.00% | Unchanged |
| BlackRock, Inc. |
| 0.01% | 0.01% | #102 | $444.5M | 6.3M | $342.7M | 5.1M | +1.2M+23.54% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.07% | 0.07% | #43 | $378.3M | 5.3M | $363.5M | 5.4M | -46,481-0.87% | Reduce |
| FMR LLC |
| 0.01% | 0.01% | #75 | $295.7M | 4.2M | $254.8M | 3.8M | +396,649+10.54% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.03% | 0.03% | #61 | $270.3M | 3.8M | $247.2M | 3.7M | +152,030+4.16% | Add |
| TCG Crossover Management, LLC |
| 6.27% | 7.11% | #8 | $260.8M | 3.7M | $248.4M | 3.7M | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #82 | $246.2M | 3.5M | $209.5M | 3.1M | +370,099+11.96% | Add |
| Caption Management, LLC |
| 1.15% | 1.09% | #14 | $245.8M | 3.5M | $186.7M | 2.8M | +699,981+25.37% | Add |
| STATE STREET CORP |
| 0.01% | 0.01% | #100 | $244.2M | 3.4M | $179.2M | 2.6M | +790,536+29.86% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #113 | $235.7M | 3.3M | $205.3M | 3.0M | +283,168+9.33% | Add |
| Foresite Capital Management VI LLC |
| 26.2% | 32.67% | #2 | $168.4M | 2.4M | $150.3M | 2.2M | +148,100+6.67% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #96 | $153.0M | 2.2M | $108.1M | 1.6M | +556,413+34.84% | Add |
| EcoR1 Capital, LLC |
| 7.1% | 3.17% | #7 | $146.1M | 2.1M | $74.6M | 1.1M | +953,800+86.55% | Add |
| Seven Fleet Capital Management LP |
| 22.12% | 1.63% | #3 | $134.0M | 1.9M | $5.1M | 75,758 | +1.8M+2,389.82% | Add |
| DV Trading LLC |
| 3.35% | 2.31% | #10 | $102.3M | 1.4M | $97.4M | 1.4M | 00.00% | Unchanged |
| Avidity Partners Management LP |
| 15.92% | 17.67% | #6 | $99.4M | 1.4M | $87.2M | 1.3M | +110,000+8.53% | Add |
| FRANKLIN RESOURCES INC |
| 0.02% | 0.02% | #68 | $93.3M | 1.3M | $102.0M | 1.5M | -194,125-12.88% | Reduce |
| ALLIANCEBERNSTEIN L.P. |
| 0.03% | 0.02% | #57 | $93.0M | 1.4M | $53.6M | 1.3M | +84,062+6.52% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #121 | $83.6M | 1.2M | $25.9M | 642,414 | +534,695+83.23% | Add |
| ACORN CAPITAL ADVISORS, LLC |
| 21.94% | 21.77% | #4 | $80.4M | 1.1M | $76.6M | 1.1M | +999+0.09% | Add |
| Foresite Capital Management V, LLC |
| 21.17% | 25.08% | #5 | $76.7M | 1.1M | $68.0M | 1.0M | +75,000+7.47% | Add |
| Logos Global Management LP |
| 3.06% | 1.94% | #11 | $71.1M | 1.0M | $38.9M | 575,000 | +425,000+73.91% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | 0.01% | #118 | $70.0M | 984,918 | $98.1M | 1.4M | -464,446-32.04% | Reduce |
| UBS Group AG |
| 0.01% | 0.01% | #93 | $69.5M | 977,695 | $88.8M | 1.3M | -334,283-25.48% | Reduce |
| ORBIMED ADVISORS LLC |
| 1.3% | 1.27% | #13 | $69.1M | 972,800 | $64.2M | 948,267 | +24,533+2.59% | Add |
| SG Americas Securities, LLC |
| 0.03% | <0.01% | #58 | $61.6M | 867,465 | $1.7M | 24,632 | +842,833+3,421.70% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #111 | $60.9M | 857,713 | $78.5M | 1.2M | -301,526-26.01% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #116 | $58.9M | 828,553 | $29.3M | 432,703 | +395,850+91.48% | Add |
| Jefferies Financial Group Inc. |
| 0.36% | — | #23 | $54.7M | 769,947 | $0 | 0 | +769,947 | New Buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.01% | 0.01% | #88 | $54.1M | 761,807 | $72.1M | 1.1M | -303,159-28.47% | Reduce |
| Clearbridge Investments, LLC |
| 0.04% | 0.04% | #49 | $52.3M | 735,736 | $49.4M | 730,283 | +5,453+0.75% | Add |
| AMERICAN CENTURY COMPANIES INC |
| 0.02% | <0.01% | #67 | $51.6M | 726,154 | $332,106 | 4,907 | +721,247+14,698.33% | Add |
| NORTHERN TRUST CORP |
| 0.01% | <0.01% | #108 | $48.2M | 677,912 | $35.2M | 519,669 | +158,243+30.45% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #106 | $44.6M | 627,185 | $36.7M | 542,378 | +84,807+15.64% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #95 | $38.2M | 538,289 | $31.8M | 470,257 | +68,032+14.47% | Add |
| Bellevue Group AG |
| 0.74% | — | #16 | $35.1M | 493,596 | $0 | 0 | +493,596 | New Buy |
| Woodline Partners LP |
| 0.11% | 0.13% | #35 | $35.0M | 492,891 | $33.4M | 492,891 | 00.00% | Unchanged |
| Candriam S.C.A. |
| 0.15% | 0.17% | #30 | $33.3M | 469,170 | $33.1M | 797,615 | -328,445-41.18% | Reduce |
| Fisher Asset Management, LLC |
| 0.01% | 0.01% | #90 | $32.5M | 456,978 | $31.5M | 465,033 | -8,055-1.73% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #154 | $31.0M | 417,726 | $35.8M | 559,586 | -141,860-25.35% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #109 | $30.8M | 433,882 | $29.7M | 438,673 | -4,791-1.09% | Reduce |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.13% | 0.26% | #31 | $28.4M | 400,000 | $45.6M | 674,000 | -274,000-40.65% | Reduce |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.04% | 0.04% | #52 | $27.7M | 390,458 | $27.1M | 399,858 | -9,400-2.35% | Reduce |
| Ensign Peak Advisors, Inc |
| 0.04% | 0.06% | #48 | $27.0M | 380,546 | $30.9M | 456,012 | -75,466-16.55% | Reduce |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.35% | 0.41% | #24 | $26.3M | 369,839 | $25.0M | 369,985 | -146-0.04% | Reduce |
| LORD, ABBETT & CO. LLC |
| 0.07% | 0.08% | #42 | $25.9M | 364,539 | $23.0M | 340,197 | +24,342+7.16% | Add |
| JENNISON ASSOCIATES LLC |
| 0.01% | 0.02% | #74 | $22.5M | 317,235 | $32.2M | 476,136 | -158,901-33.37% | Reduce |
| FEDERATED HERMES, INC. |
| 0.03% | 0.02% | #56 | $22.1M | 311,236 | $10.1M | 148,750 | +162,486+109.23% | Add |
