| BlackRock, Inc. |
| <0.01% | <0.01% | #90 | $211.3M | 4.7M | $183.1M | 3.5M | +1.2M+33.47% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.02% | 0.02% | #46 | $106.3M | 2.4M | $130.8M | 2.5M | -153,294-6.04% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #77 | $93.2M | 2.1M | $84.4M | 1.6M | +451,788+27.60% | Add |
| Soleus Capital Management, L.P. |
| 2.97% | 1.2% | #1 | $86.2M | 1.9M | $29.7M | 576,299 | +1.4M+235.14% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| 0.03% | 0.01% | #42 | $80.9M | 1.9M | $15.9M | 308,662 | +1.5M+501.56% | Add |
| UBS Group AG |
| 0.01% | <0.01% | #60 | $73.4M | 1.6M | $33.0M | 638,928 | +1.0M+157.54% | Add |
| D. E. Shaw & Co., Inc. |
| 0.03% | 0.04% | #38 | $65.6M | 1.5M | $61.9M | 1.2M | +270,825+22.58% | Add |
| NOMURA HOLDINGS INC |
| 0.07% | — | #21 | $61.1M | 1.4M | $0 | 0 | +1.4M | New Buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.6% | 1.64% | #5 | $57.9M | 1.3M | $139.4M | 2.7M | -1.4M-52.03% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #140 | $56.7M | 1.3M | $65.3M | 1.3M | +4,190+0.33% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #121 | $53.8M | 1.2M | $49.3M | 956,011 | +250,483+26.20% | Add |
| Assenagon Asset Management S.A. |
| 0.05% | 0.04% | #32 | $38.6M | 864,395 | $26.8M | 520,174 | +344,221+66.17% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #113 | $35.3M | 791,222 | $33.4M | 450,641 | +340,581+75.58% | Add |
| Artisan Partners Limited Partnership |
| 0.05% | 0.06% | #29 | $32.7M | 732,323 | $40.3M | 780,575 | -48,252-6.18% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #118 | $31.3M | 700,836 | $26.3M | 510,234 | +190,602+37.36% | Add |
| BRAIDWELL LP |
| 1.12% | 1.17% | #3 | $30.2M | 677,570 | $34.9M | 677,570 | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #100 | $28.8M | 645,858 | $34.2M | 664,003 | -18,145-2.73% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #91 | $25.9M | 580,934 | $24.9M | 483,076 | +97,858+20.26% | Add |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | <0.01% | #74 | $24.4M | 546,020 | $23.1M | 448,787 | +97,233+21.67% | Add |
| SG Americas Securities, LLC |
| 0.01% | 0.01% | #54 | $21.9M | 491,703 | $5.4M | 105,147 | +386,556+367.63% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | 0.01% | #61 | $19.1M | 428,069 | $16.5M | 319,758 | +108,311+33.87% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.03% | 0.04% | #43 | $19.0M | 426,000 | $24.2M | 469,968 | -43,968-9.36% | Reduce |
| ADAR1 Capital Management, LLC |
| 0.77% | 1.23% | #4 | $16.7M | 374,617 | $20.9M | 405,197 | -30,580-7.55% | Reduce |
| Aberdeen Group plc |
| 0.02% | 0.04% | #45 | $16.0M | 358,968 | $24.6M | 477,476 | -118,508-24.82% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #117 | $14.9M | 334,039 | $10.2M | 197,033 | +137,006+69.53% | Add |
| BARCLAYS PLC |
| <0.01% | <0.01% | #98 | $13.7M | 307,270 | $3.5M | 67,641 | +239,629+354.27% | Add |
| FEDERATED HERMES, INC. |
| 0.02% | <0.01% | #47 | $12.1M | 272,130 | $4,694 | 91 | +272,039+298,943.96% | Add |
| Nantahala Capital Management, LLC |
| 0.4% | — | #7 | $12.0M | 269,474 | $0 | 0 | +269,474 | New Buy |
| FMR LLC |
| <0.01% | <0.01% | #184 | $11.9M | 267,871 | $2.0M | 37,984 | +229,887+605.22% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #170 | $11.1M | 248,802 | $9.6M | 186,069 | +62,733+33.71% | Add |
| Walleye Capital LLC |
| 0.04% | 0.08% | #36 | $11.0M | 245,763 | $18.5M | 359,389 | -113,626-31.62% | Reduce |
| Rock Springs Capital Management LP |
| 0.53% | 0.4% | #6 | $10.9M | 244,000 | $6.8M | 131,800 | +112,200+85.13% | Add |
| CAPITAL FUND MANAGEMENT S.A. |
| 0.04% | 0.03% | #35 | $9.8M | 219,873 | $5.6M | 109,015 | +110,858+101.69% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #136 | $9.4M | 210,091 | $9.5M | 183,351 | +26,740+14.58% | Add |
| NORGES BANK |
| <0.01% | <0.01% | #156 | $8.8M | 198,272 | $25.8M | 161,961 | +36,311+22.42% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #174 | $8.7M | 194,498 | $18.2M | 353,773 | -159,275-45.02% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #112 | $8.5M | 190,563 | $8.6M | 167,700 | +22,863+13.63% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | 0.01% | #103 | $7.9M | 176,200 | $26.5M | 513,175 | -336,975-65.66% | Reduce |
| TUDOR INVESTMENT CORP ET AL |
| 0.01% | 0.02% | #56 | $7.5M | 169,095 | $8.9M | 172,818 | -3,723-2.15% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #167 | $7.5M | 167,733 | $9.4M | 181,313 | -13,580-7.49% | Reduce |
| CANADA PENSION PLAN INVESTMENT BOARD |
| <0.01% | 0.01% | #80 | $7.4M | 165,100 | $8.5M | 164,100 | +1,000+0.61% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #145 | $6.6M | 148,627 | $7.7M | 148,764 | -137-0.09% | Reduce |
| BANK OF NOVA SCOTIA |
| 0.01% | 0.01% | #58 | $6.5M | 144,964 | $3.1M | 60,000 | +84,964+141.61% | Add |
| Quantinno Capital Management LP |
| 0.01% | <0.01% | #68 | $6.1M | 137,615 | $1.4M | 26,555 | +111,060+418.23% | Add |
| Edgestream Partners, L.P. |
| 0.18% | 0.14% | #15 | $6.0M | 133,766 | $4.2M | 82,268 | +51,498+62.60% | Add |
| PRINCIPAL FINANCIAL GROUP INC |
| <0.01% | <0.01% | #93 | $5.7M | 128,175 | $6.5M | 126,788 | +1,387+1.09% | Add |
| Alberta Investment Management Corp |
| 0.03% | — | #39 | $5.5M | 122,900 | $0 | 0 | +122,900 | New Buy |
| Rheos Capital Works Inc. |
| 0.3% | 0.4% | #9 | $5.2M | 117,400 | $6.1M | 117,400 | 00.00% | Unchanged |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #152 | $5.2M | 115,907 | $12.1M | 234,670 | -118,763-50.61% | Reduce |
| Invesco Ltd. |
| <0.01% | <0.01% | #196 | $4.9M | 110,285 | $5.4M | 103,973 | +6,312+6.07% | Add |
