| BlackRock, Inc. |
| <0.01% | <0.01% | #145 | $244.9M | 3.0M | $211.3M | 2.7M | +211,154+7.69% | Add |
| Soleus Capital Management, L.P. |
| 2.48% | 2.55% | #4 | $71.8M | 867,760 | $63.1M | 820,243 | +47,517+5.79% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #195 | $69.4M | 838,224 | $63.3M | 823,064 | +15,160+1.84% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #171 | $68.9M | 831,647 | $59.3M | 771,587 | +60,060+7.78% | Add |
| TANG CAPITAL MANAGEMENT LLC |
| 2.66% | 2.76% | #3 | $58.6M | 707,500 | $54.4M | 707,500 | 00.00% | Unchanged |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #102 | $51.6M | 623,463 | $40.8M | 531,190 | +92,273+17.37% | Add |
| AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.01% | #71 | $47.6M | 574,474 | $14.7M | 191,576 | +382,898+199.87% | Add |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.02% | 0.02% | #74 | $46.5M | 562,016 | $43.4M | 564,360 | -2,344-0.42% | Reduce |
| Global Alpha Capital Management Ltd. |
| 2.77% | 1.67% | #2 | $46.2M | 558,003 | $27.8M | 361,240 | +196,763+54.47% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #165 | $44.4M | 536,407 | $37.6M | 489,201 | +47,206+9.65% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.02% | #88 | $42.0M | 507,207 | $45.5M | 592,013 | -84,806-14.33% | Reduce |
| Nuveen, LLC |
| 0.01% | 0.01% | #110 | $34.4M | 415,024 | $30.9M | 402,357 | +12,667+3.15% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #192 | $33.7M | 407,281 | $28.9M | 375,965 | +31,316+8.33% | Add |
| Ranger Investment Management, L.P. |
| 1.8% | 2% | #6 | $28.4M | 343,150 | $27.7M | 360,083 | -16,933-4.70% | Reduce |
| DEUTSCHE BANK AG\ |
| 0.01% | 0.01% | #112 | $26.8M | 323,443 | $24.6M | 319,675 | +3,768+1.18% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #173 | $25.6M | 309,233 | $24.9M | 324,349 | -15,116-4.66% | Reduce |
| UBS Group AG |
| <0.01% | 0.01% | #150 | $24.6M | 297,539 | $38.3M | 497,702 | -200,163-40.22% | Reduce |
| KENNEDY CAPITAL MANAGEMENT LLC |
| 0.43% | 0.48% | #20 | $24.5M | 295,938 | $22.6M | 293,996 | +1,942+0.66% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #131 | $23.8M | 287,382 | $20.8M | 270,262 | +17,120+6.33% | Add |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.04% | 0.04% | #59 | $23.8M | 287,206 | $22.1M | 287,563 | -357-0.12% | Reduce |
| Ikarian Capital, LLC |
| 2.39% | 1.85% | #5 | $22.5M | 272,085 | $22.8M | 297,085 | -25,000-8.42% | Reduce |
| Aberdeen Group plc |
| 0.03% | 0.03% | #62 | $22.5M | 271,760 | $15.9M | 206,123 | +65,637+31.84% | Add |
| OBERWEIS ASSET MANAGEMENT INC/ |
| 0.45% | 0.5% | #19 | $22.0M | 265,306 | $17.0M | 221,386 | +43,920+19.84% | Add |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC |
| 0.06% | 0.08% | #46 | $21.4M | 258,173 | $25.2M | 327,276 | -69,103-21.11% | Reduce |
| Rubric Capital Management LP |
| 0.2% | — | #31 | $21.4M | 258,131 | $0 | 0 | +258,131 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #157 | $20.9M | 252,574 | $18.0M | 234,288 | +18,286+7.80% | Add |
| Caption Management, LLC |
| 0.09% | 0.24% | #42 | $19.9M | 240,000 | $41.2M | 535,890 | -295,890-55.21% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #202 | $19.7M | 232,954 | $16.2M | 220,166 | +12,788+5.81% | Add |
| NOMURA HOLDINGS INC |
| 0.02% | 0.05% | #70 | $19.4M | 233,955 | $18.2M | 237,225 | -3,270-1.38% | Reduce |
| Jones Hill Capital LP |
| 4.11% | 5.25% | #1 | $19.4M | 233,808 | $24.5M | 318,591 | -84,783-26.61% | Reduce |
| BANK OF MONTREAL /CAN/ |
| 0.01% | 0.01% | #119 | $18.6M | 224,707 | $17.7M | 230,072 | -5,365-2.33% | Reduce |
| TEACHER RETIREMENT SYSTEM OF TEXAS |
| 0.05% | 0.07% | #52 | $18.2M | 220,030 | $16.9M | 220,224 | -194-0.09% | Reduce |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #160 | $17.6M | 212,192 | $16.5M | 213,919 | -1,727-0.81% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #208 | $17.5M | 211,167 | $21.3M | 232,026 | -20,859-8.99% | Reduce |
| MIZUHO MARKETS AMERICAS LLC |
| 0.24% | 0.44% | #26 | $17.4M | 209,644 | $16.2M | 210,768 | -1,124-0.53% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #174 | $17.3M | 209,163 | $14.2M | 184,852 | +24,311+13.15% | Add |
| Penn Capital Management Company, LLC |
| 1.09% | 1.07% | #12 | $17.2M | 207,362 | $13.8M | 179,716 | +27,646+15.38% | Add |
| Parkman Healthcare Partners LLC |
| 1.72% | 2.23% | #7 | $16.8M | 202,907 | $21.6M | 280,575 | -77,668-27.68% | Reduce |
| Qube Research & Technologies Ltd |
| 0.01% | 0.02% | #86 | $16.0M | 192,945 | $16.2M | 210,130 | -17,185-8.18% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #205 | $15.2M | 183,066 | $11.6M | 150,532 | +32,534+21.61% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #196 | $15.1M | 182,236 | $16.9M | 219,755 | -37,519-17.07% | Reduce |
| D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #114 | $14.5M | 174,732 | $16.4M | 213,433 | -38,701-18.13% | Reduce |
| LOOMIS SAYLES & CO L P |
| 0.02% | 0.02% | #83 | $13.5M | 162,792 | $12.5M | 162,986 | -194-0.12% | Reduce |
| NEW YORK STATE COMMON RETIREMENT FUND |
| 0.02% | 0.01% | #84 | $12.8M | 154,995 | $9.5M | 124,100 | +30,895+24.90% | Add |
| Russell Investments Group, Ltd. |
| 0.01% | 0.01% | #103 | $11.5M | 138,588 | $10.7M | 138,941 | -353-0.25% | Reduce |
| CITIGROUP INC |
| <0.01% | <0.01% | #143 | $11.3M | 136,411 | $11.1M | 144,281 | -7,870-5.45% | Reduce |
| PRINCIPAL FINANCIAL GROUP INC |
| 0.01% | 0.01% | #125 | $11.1M | 134,151 | $9.9M | 129,148 | +5,003+3.87% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #163 | $11.1M | 133,587 | $9.8M | 127,189 | +6,398+5.03% | Add |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #153 | $10.9M | 131,270 | $6.2M | 80,620 | +50,650+62.83% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.06% | 0.07% | #48 | $10.1M | 121,852 | $9.3M | 121,459 | +393+0.32% | Add |
