| GSK plc |
| 3.37% | 3.59% | #1 | $20.3M | 9.2M | $21.5M | 9.2M | 00.00% | Unchanged |
| PFIZER INC |
| 3.13% | 2.31% | #2 | $5.3M | 2.4M | $5.5M | 2.4M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #29 | $4.5M | 2.0M | $4.2M | 1.8M | +236,346+13.13% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #12 | $2.1M | 947,904 | $2.8M | 1.2M | -241,331-20.29% | Reduce |
| Alphabet Inc. |
| 0.05% | 0.05% | #4 | $2.1M | 889,979 | $2.1M | 889,979 | 00.00% | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #27 | $1.8M | 807,590 | $892,979 | 381,615 | +425,975+111.62% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #44 | $1.3M | 594,404 | $1.0M | 433,202 | +161,202+37.21% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #32 | $1.3M | 566,329 | $1.2M | 519,922 | +46,407+8.93% | Add |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | — | #24 | $1.2M | 521,705 | $0 | 0 | +521,705 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #21 | $846,019 | 382,814 | $2.1M | 885,631 | -502,817-56.77% | Reduce |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | — | #23 | $735,864 | 332,970 | $0 | 0 | +332,970 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #26 | $635,702 | 287,648 | $618,029 | 264,115 | +23,533+8.91% | Add |
| GSA CAPITAL PARTNERS LLP |
| 0.04% | 0.04% | #5 | $631,852 | 285,906 | $651,000 | 278,304 | +7,602+2.73% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #28 | $607,616 | 274,820 | $69,207 | 29,768 | +245,052+823.21% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | — | #35 | $567,937 | 256,985 | $0 | 0 | +256,985 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #36 | $512,713 | 231,997 | $427,389 | 182,645 | +49,352+27.02% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #47 | $474,600 | 214,751 | $502,517 | 214,751 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #37 | $308,693 | 139,680 | $7,041 | 3,009 | +136,671+4,542.07% | Add |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | 0.01% | #11 | $253,708 | 114,800 | $268,632 | 114,800 | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #41 | $239,286 | 108,274 | $283,103 | 120,984 | -12,710-10.51% | Reduce |
| Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #25 | $230,673 | 104,377 | $139,623 | 59,668 | +44,709+74.93% | Add |
| Ionic Capital Management LLC |
| 0.03% | 0.03% | #6 | $226,963 | 102,698 | $458,497 | 195,939 | -93,241-47.59% | Reduce |
| Federation des caisses Desjardins du Quebec |
| <0.01% | — | #20 | $202,180 | 91,900 | $0 | 0 | +91,900 | New Buy |
| Shay Capital LLC |
| 0.01% | 0.01% | #8 | $159,984 | 72,391 | $164,628 | 70,354 | +2,037+2.90% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #45 | $144,976 | 65,600 | $996,040 | 425,658 | -360,058-84.59% | Reduce |
| Invesco Ltd. |
| <0.01% | <0.01% | #49 | $141,981 | 64,245 | $106,175 | 45,374 | +18,871+41.59% | Add |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #30 | $135,499 | 61,312 | $70,911 | 30,304 | +31,008+102.32% | Add |
| Verdad Advisers, LP |
| 0.11% | 0.09% | #3 | $113,450 | 51,335 | $78,285 | 33,455 | +17,880+53.44% | Add |
| XTX Topco Ltd |
| <0.01% | — | #15 | $111,685 | 50,536 | $0 | 0 | +50,536 | New Buy |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | — | #38 | $81,352 | 36,811 | $0 | 0 | +36,811 | New Buy |
| Capital Asset Advisory Services LLC |
| <0.01% | <0.01% | #13 | $71,931 | 32,548 | $92,436 | 32,548 | 00.00% | Unchanged |
| AXXCESS WEALTH MANAGEMENT, LLC |
| <0.01% | — | #16 | $71,931 | 32,548 | $0 | 0 | +32,548 | New Buy |
| Three Seasons Wealth, LLC |
| 0.01% | 0.03% | #10 | $66,300 | 30,000 | $70,200 | 30,000 | 00.00% | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #50 | $63,129 | 28,565 | $66,842 | 28,565 | 00.00% | Unchanged |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #42 | $56,236 | 25,446 | $59,544 | 25,446 | 00.00% | Unchanged |
| Global Retirement Partners, LLC |
| <0.01% | — | #17 | $55,250 | 25,000 | $0 | 0 | +25,000 | New Buy |
| OPPENHEIMER & CO INC |
| <0.01% | — | #22 | $50,499 | 22,850 | $0 | 0 | +22,850 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #46 | $42,649 | 19,298 | $0 | 0 | +19,298 | New Buy |
| Assenagon Asset Management S.A. |
| <0.01% | <0.01% | #34 | $41,186 | 18,636 | $43,608 | 18,636 | 00.00% | Unchanged |
| DLK Investment Management, LLC |
| 0.02% | — | #7 | $40,762 | 31,355 | $0 | 0 | +31,355 | New Buy |
| Susquehanna Portfolio Strategies, LLC |
| <0.01% | — | #19 | $38,958 | 17,628 | $0 | 0 | +17,628 | New Buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
| <0.01% | — | #18 | $35,570 | 16,095 | $0 | 0 | +16,095 | New Buy |
| Qube Research & Technologies Ltd |
| <0.01% | — | #40 | $30,153 | 13,644 | $0 | 0 | +13,644 | New Buy |
| SG Americas Securities, LLC |
| <0.01% | — | #48 | $24,902 | 11,268 | $0 | 0 | +11,268 | New Buy |
| GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #39 | $24,020 | 10,869 | $43,056 | 18,400 | -7,531-40.93% | Reduce |
| TWO SIGMA SECURITIES, LLC |
| <0.01% | — | #14 | $23,373 | 10,576 | $0 | 0 | +10,576 | New Buy |
| PRUDENTIAL FINANCIAL INC |
| <0.01% | — | #43 | $22,984 | 10,400 | $0 | 0 | +10,400 | New Buy |
| CITIGROUP INC |
| <0.01% | <0.01% | #51 | $21,271 | 9,625 | $44,776 | 19,135 | -9,510-49.70% | Reduce |
| FNY Investment Advisers, LLC |
| 0.01% | 0.01% | #9 | $18,343 | 8,300 | $12,000 | 5,300 | +3,000+56.60% | Add |
| JONES FINANCIAL COMPANIES LLLP |
| <0.01% | <0.01% | #52 | $17,352 | 7,678 | $17,890 | 7,678 | 00.00% | Unchanged |
