| Bain Capital Life Sciences Investors, LLC |
| 0.38% | 0.5% | #1 | $6.4M | 664,021 | $5.6M | 664,021 | 00.00% | Unchanged |
| GILEAD SCIENCES, INC. |
| 0.38% | 0.26% | #2 | $6.2M | 650,389 | $5.5M | 650,389 | 00.00% | Unchanged |
| ORBIMED ADVISORS LLC |
| 0.11% | — | #6 | $5.7M | 592,300 | $0 | 0 | +592,300 | New Buy |
| Frazier Life Sciences Management, L.P. |
| 0.09% | 0.09% | #7 | $4.0M | 422,505 | $3.6M | 422,505 | 00.00% | Unchanged |
| Stonepine Capital Management, LLC |
| 0.33% | 0.22% | #3 | $2.2M | 225,994 | $539,602 | 64,162 | +161,832+252.22% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #17 | $1.7M | 178,517 | $1.0M | 123,660 | +54,857+44.36% | Add |
| Sio Capital Management, LLC |
| 0.24% | 0.18% | #4 | $1.5M | 152,464 | $1.3M | 152,464 | 00.00% | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | — | #12 | $1.1M | 111,541 | $0 | 0 | +111,541 | New Buy |
| Merck & Co., Inc. |
| 0.19% | 0.26% | #5 | $1.0M | 105,982 | $891,309 | 105,982 | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #13 | $614,586 | 64,153 | $416,850 | 49,566 | +14,587+29.43% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #19 | $545,619 | 56,954 | $810,607 | 961,917 | -904,963-94.08% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #21 | $374,174 | 39,055 | $312,848 | 37,197 | +1,858+5.00% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | — | #20 | $248,601 | 25,950 | $0 | 0 | +25,950 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #16 | $216,451 | 22,594 | $239,475 | 28,475 | -5,881-20.65% | Reduce |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | — | #11 | $168,072 | 17,544 | $0 | 0 | +17,544 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #14 | $139,332 | 14,544 | $0 | 0 | +14,544 | New Buy |
| Velan Capital Investment Management LP |
| 0.08% | 0.08% | #8 | $136,850 | 14,285 | $120,137 | 14,285 | 00.00% | Unchanged |
| GSA CAPITAL PARTNERS LLP |
| 0.01% | 0.01% | #9 | $130,192 | 13,590 | $143,000 | 16,946 | -3,356-19.80% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #22 | $127,519 | 13,311 | $111,946 | 13,311 | 00.00% | Unchanged |
| PRELUDE CAPITAL MANAGEMENT, LLC |
| 0.01% | — | #10 | $111,128 | 11,600 | $0 | 0 | +11,600 | New Buy |
| BlackRock, Inc. |
| <0.01% | — | #23 | $83,892 | 8,757 | $0 | 0 | +8,757 | New Buy |
| Steward Partners Investment Advisory, LLC |
| <0.01% | — | #18 | $6,840 | 714 | $0 | 0 | +714 | New Buy |
| BARCLAYS PLC |
| <0.01% | — | #24 | $1,102 | 115 | $0 | 0 | +115 | New Buy |
| Key FInancial Inc |
| <0.01% | <0.01% | #15 | $565 | 59 | $496 | 59 | 00.00% | Unchanged |
| JONES FINANCIAL COMPANIES LLLP |
| <0.01% | — | #25 | $262 | 29 | $0 | 0 | +29 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #26 | $134 | 14 | $33,960 | 4,038 | -4,024-99.65% | Reduce |
