| FMR LLC |
| 0.04% | 0.02% | #82 | $862.0M | 9.1M | $364.5M | 7.4M | +1.6M+21.88% | Add |
| BlackRock, Inc. |
| 0.01% | <0.01% | #126 | $474.9M | 5.0M | $173.0M | 3.5M | +1.5M+41.48% | Add |
| Venrock Adviser, LLC |
| 11.97% | 7.6% | #3 | $394.8M | 4.1M | $203.5M | 4.1M | 00.00% | Unchanged |
| Fairmount Funds Management LLC |
| 23.31% | 13.13% | #2 | $352.6M | 3.7M | $181.7M | 3.7M | 00.00% | Unchanged |
| Capital World Investors |
| 0.04% | — | #81 | $323.7M | 3.4M | $0 | 0 | +3.4M | New Buy |
| RTW INVESTMENTS, LP |
| 2.55% | 1% | #16 | $298.7M | 3.1M | $101.0M | 2.1M | +1.1M+52.52% | Add |
| STATE STREET CORP |
| 0.01% | <0.01% | #124 | $254.4M | 2.7M | $79.1M | 1.6M | +1.1M+65.67% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #135 | $224.7M | 2.4M | $91.2M | 1.9M | +501,340+26.96% | Add |
| Paradigm Biocapital Advisors LP |
| 3.82% | 2.33% | #5 | $204.1M | 2.1M | $113.8M | 2.3M | -175,790-7.58% | Reduce |
| Deep Track Capital, LP |
| 2.67% | 1.63% | #14 | $183.3M | 1.9M | $99.8M | 2.0M | -108,203-5.32% | Reduce |
| Bellevue Group AG |
| 3.32% | 0.59% | #8 | $157.7M | 1.7M | $24.9M | 507,008 | +1.2M+226.86% | Add |
| FRANKLIN RESOURCES INC |
| 0.03% | 0.01% | #85 | $154.3M | 1.6M | $49.2M | 1.0M | +617,395+61.49% | Add |
| Remedium Capital Partners, LLC |
| 32.99% | 27.31% | #1 | $149.0M | 1.6M | $76.8M | 1.6M | 00.00% | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. |
| 1.29% | — | #24 | $148.0M | 1.6M | $0 | 0 | +1.6M | New Buy |
| VIKING GLOBAL INVESTORS LP |
| 0.41% | 0.37% | #42 | $143.1M | 1.5M | $130.8M | 2.7M | -1.2M-43.62% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #125 | $136.1M | 1.4M | $46.8M | 954,867 | +475,087+49.75% | Add |
| Jupiter Topco LLC |
| 0.05% | — | #75 | $131.0M | 1.4M | $0 | 0 | +1.4M | New Buy |
| PERCEPTIVE ADVISORS LLC |
| 1.92% | 1.34% | #18 | $128.0M | 1.3M | $68.4M | 1.4M | -50,438-3.61% | Reduce |
| Polar Capital Holdings Plc |
| 0.28% | 0.18% | #46 | $116.9M | 1.2M | $51.4M | 1.0M | +180,916+17.27% | Add |
| CITADEL ADVISORS LLC |
| 0.01% | 0.01% | #104 | $109.7M | 1.2M | $50.0M | 1.0M | +134,074+13.16% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.07% | — | #67 | $105.0M | 1.1M | $0 | 0 | +1.1M | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.05% | <0.01% | #77 | $102.7M | 1.1M | $536,018 | 10,928 | +1.1M+9,773.86% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #121 | $79.8M | 838,603 | $35.7M | 727,449 | +111,154+15.28% | Add |
| Avidity Partners Management LP |
| 11.59% | 7.55% | #4 | $72.4M | 760,424 | $37.3M | 760,424 | 00.00% | Unchanged |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC |
| 1.1% | — | #26 | $62.7M | 658,301 | $0 | 0 | +658,301 | New Buy |
| Aberdeen Group plc |
| 0.09% | 0.01% | #64 | $61.6M | 646,943 | $3.7M | 75,680 | +571,263+754.84% | Add |
| UBS Group AG |
| 0.01% | <0.01% | #122 | $60.8M | 639,363 | $10.4M | 212,271 | +427,092+201.20% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #149 | $60.7M | 655,027 | $1.0M | 22,620 | +632,407+2,795.79% | Add |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.2% | 0.06% | #48 | $60.1M | 631,433 | $15.4M | 313,130 | +318,303+101.65% | Add |
| Pictet Asset Management Holding SA |
| 0.06% | — | #72 | $58.9M | 619,076 | $0 | 0 | +619,076 | New Buy |
| Affinity Asset Advisors, LLC |
| 2.54% | 1.27% | #17 | $56.2M | 590,000 | $24.5M | 499,673 | +90,327+18.08% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #158 | $55.4M | 582,409 | $17.2M | 350,892 | +231,517+65.98% | Add |
| Cormorant Asset Management, LP |
| 2.58% | 1.31% | #15 | $50.8M | 533,340 | $26.2M | 533,340 | 00.00% | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | <0.01% | #132 | $41.2M | 433,405 | $15.8M | 321,949 | +111,456+34.62% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #136 | $40.8M | 428,891 | $14.7M | 299,044 | +129,847+43.42% | Add |
| VOYA INVESTMENT MANAGEMENT LLC |
| 0.03% | <0.01% | #84 | $38.2M | 401,149 | $3.3M | 66,600 | +334,549+502.33% | Add |
| LORD, ABBETT & CO. LLC |
| 0.11% | — | #60 | $37.1M | 390,064 | $0 | 0 | +390,064 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | <0.01% | #123 | $34.8M | 365,630 | $12.6M | 257,071 | +108,559+42.23% | Add |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | — | #109 | $34.7M | 364,102 | $0 | 0 | +364,102 | New Buy |
| Synergy Asset Management, LLC |
| 3.2% | 2.48% | #10 | $33.9M | 356,301 | $23.4M | 476,196 | -119,895-25.18% | Reduce |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.05% | 0.01% | #78 | $33.8M | 355,003 | $9.3M | 190,030 | +164,973+86.81% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #161 | $33.6M | 352,824 | $4.9M | 100,091 | +252,733+252.50% | Add |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 3.49% | 0.76% | #6 | $33.6M | 352,802 | $7.4M | 150,908 | +201,894+133.79% | Add |
| Candriam S.C.A. |
| 0.15% | 0.06% | #55 | $33.5M | 352,716 | $12.1M | 400,509 | -47,793-11.93% | Reduce |
| Holocene Advisors, LP |
| 0.07% | 0.02% | #69 | $29.1M | 305,951 | $9.1M | 185,513 | +120,438+64.92% | Add |
| JENNISON ASSOCIATES LLC |
| 0.02% | 0.01% | #100 | $28.5M | 299,257 | $8.7M | 176,680 | +122,577+69.38% | Add |
| Woodline Partners LP |
| 0.08% | 0.11% | #65 | $27.1M | 285,247 | $28.2M | 574,882 | -289,635-50.38% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #164 | $26.6M | 279,788 | $3.4M | 70,184 | +209,604+298.65% | Add |
| BRAIDWELL LP |
| 0.98% | — | #28 | $26.5M | 278,164 | $0 | 0 | +278,164 | New Buy |
| Siren, L.L.C. |
| 0.48% | — | #36 | $23.8M | 250,000 | $0 | 0 | +250,000 | New Buy |
