| TCG Crossover Management, LLC |
| 19.24% | 20.65% | #1 | $800.6M | 6.0M | $721.7M | 6.5M | -473,251-7.30% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.05% | 0.02% | #126 | $619.4M | 4.6M | $143.1M | 1.3M | +3.4M+261.77% | Add |
| CITADEL ADVISORS LLC |
| 0.06% | 0.02% | #118 | $565.5M | 4.2M | $149.1M | 1.3M | +2.9M+216.93% | Add |
| Helikon Investments Ltd |
| 11.1% | 4.26% | #11 | $371.4M | 2.8M | $112.8M | 1.0M | +1.8M+175.05% | Add |
| Darwin Global Management, Ltd. |
| 9.26% | 9.34% | #16 | $348.2M | 3.6M | $352.1M | 3.5M | +152,926+4.41% | Add |
| Vestal Point Capital, LP |
| 7.32% | 4.67% | #19 | $313.1M | 2.3M | $167.0M | 1.5M | +849,443+56.63% | Add |
| Jupiter Topco LLC |
| 0.1% | — | #107 | $255.1M | 1.9M | $0 | 0 | +1.9M | New Buy |
| UBS Group AG |
| 0.03% | 0.08% | #140 | $247.9M | 1.9M | $506.4M | 4.5M | -2.7M-59.08% | Reduce |
| ADAR1 Capital Management, LLC |
| 11.36% | 9.43% | #9 | $246.4M | 1.8M | $160.1M | 1.4M | +411,084+28.59% | Add |
| Caligan Partners LP |
| 9.77% | 10.83% | #14 | $207.6M | 1.6M | $162.8M | 1.5M | +96,000+6.57% | Add |
| MORGAN STANLEY |
| 0.01% | 0.01% | #175 | $190.9M | 1.4M | $124.9M | 1.5M | -38,532-2.62% | Reduce |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.57% | 0.62% | #72 | $174.5M | 1.3M | $147.3M | 1.3M | -13,113-0.99% | Reduce |
| RA CAPITAL MANAGEMENT, L.P. |
| 1.31% | — | #55 | $150.9M | 1.1M | $0 | 0 | +1.1M | New Buy |
| NORGES BANK |
| 0.01% | — | #163 | $146.6M | 1.1M | $0 | 0 | +1.1M | New Buy |
| Logos Global Management LP |
| 5.87% | 3.75% | #23 | $136.5M | 1.0M | $75.2M | 675,000 | +349,000+51.70% | Add |
| Octagon Capital Advisors LP |
| 11.89% | 8.34% | #8 | $132.3M | 993,000 | $75.4M | 677,000 | +316,000+46.68% | Add |
| BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.01% | #179 | $129.5M | 971,439 | $81.9M | 735,729 | +235,710+32.04% | Add |
| Ikarian Capital, LLC |
| 12.96% | 3.16% | #5 | $122.1M | 919,735 | $38.9M | 350,935 | +568,800+162.08% | Add |
| Eversept Partners, LP |
| 6.32% | 5.49% | #21 | $121.8M | 913,880 | $104.0M | 934,423 | -20,543-2.20% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #177 | $105.6M | 792,712 | $38.8M | 348,797 | +443,915+127.27% | Add |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. |
| 5.59% | 7.23% | #24 | $102.0M | 765,332 | $85.3M | 765,915 | -583-0.08% | Reduce |
| DIADEMA PARTNERS LP |
| 12.56% | 5.19% | #7 | $101.8M | 765,244 | $30.5M | 275,944 | +489,300+177.32% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 1.33% | 0.81% | #54 | $99.7M | 748,467 | $62.3M | 559,261 | +189,206+33.83% | Add |
| ORBIMED ADVISORS LLC |
| 1.88% | 1.03% | #46 | $99.5M | 746,522 | $51.9M | 465,700 | +280,822+60.30% | Add |
| LMR Partners LLP |
| 0.36% | 0.06% | #82 | $94.8M | 711,657 | $25.4M | 227,752 | +483,905+212.47% | Add |
| Cormorant Asset Management, LP |
| 4.57% | 4.25% | #30 | $90.0M | 675,000 | $84.6M | 760,000 | -85,000-11.18% | Reduce |
| ExodusPoint Capital Management, LP |
| 0.54% | — | #73 | $83.9M | 629,409 | $0 | 0 | +629,409 | New Buy |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.1% | 0.03% | #108 | $83.2M | 624,440 | $23.8M | 213,689 | +410,751+192.22% | Add |
| Boxer Capital Management, LLC |
| 6.07% | 2.92% | #22 | $80.6M | 605,000 | $22.3M | 200,000 | +405,000+202.50% | Add |
| GREAT POINT PARTNERS LLC |
| 15.22% | — | #2 | $80.5M | 604,314 | $0 | 0 | +604,314 | New Buy |
| Siren, L.L.C. |
| 1.55% | — | #50 | $76.8M | 576,000 | $0 | 0 | +576,000 | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #239 | $76.5M | 574,061 | $47.6M | 427,335 | +146,726+34.34% | Add |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC |
| 1.34% | — | #53 | $76.0M | 570,000 | $0 | 0 | +570,000 | New Buy |
| TUDOR INVESTMENT CORP ET AL |
| 0.1% | 0.02% | #110 | $70.0M | 524,935 | $13.0M | 116,311 | +408,624+351.32% | Add |
| Aberdeen Group plc |
| 0.1% | 0.08% | #109 | $69.6M | 522,025 | $48.0M | 431,241 | +90,784+21.05% | Add |
| Saturn V Capital Management LP |
| 9.91% | 10.94% | #13 | $69.1M | 518,865 | $60.4M | 542,696 | -23,831-4.39% | Reduce |
| Artia Global Partners LP |
| 12.7% | 13.39% | #6 | $68.8M | 516,447 | $66.9M | 600,747 | -84,300-14.03% | Reduce |
| Two Seas Capital LP |
| 1.35% | — | #52 | $68.1M | 510,990 | $0 | 0 | +510,990 | New Buy |
| Ensign Peak Advisors, Inc |
| 0.11% | 0.13% | #105 | $67.2M | 504,471 | $70.4M | 631,838 | -127,367-20.16% | Reduce |
| Pictet Asset Management Holding SA |
| 0.06% | 0.01% | #120 | $65.6M | 492,068 | $11.2M | 103,545 | +388,523+375.22% | Add |
| First Turn Management, LLC |
| 6.98% | 5.8% | #20 | $65.3M | 489,889 | $51.9M | 465,869 | +24,020+5.16% | Add |
| Holocene Advisors, LP |
| 0.13% | 0.07% | #101 | $55.8M | 418,657 | $28.8M | 258,657 | +160,000+61.86% | Add |
| Vivo Capital, LLC |
| 5.05% | 2.22% | #28 | $55.3M | 414,899 | $26.7M | 239,539 | +175,360+73.21% | Add |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.7% | 0.59% | #64 | $52.6M | 394,957 | $35.7M | 320,576 | +74,381+23.20% | Add |
| MPM BioImpact LLC |
| 2.73% | 0.92% | #36 | $44.8M | 336,347 | $11.9M | 107,268 | +229,079+213.56% | Add |
| Kite Lake Capital Management (UK) LLP |
| 15.18% | 11.58% | #3 | $44.0M | 330,300 | $14.4M | 129,700 | +200,600+154.66% | Add |
| Affinity Asset Advisors, LLC |
| 1.99% | 2.33% | #45 | $44.0M | 330,000 | $45.1M | 405,000 | -75,000-18.52% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.03% | #164 | $41.0M | 307,640 | $69.2M | 621,092 | -313,452-50.47% | Reduce |
| Melqart Asset Management (UK) Ltd |
| 3.9% | — | #32 | $40.9M | 307,250 | $0 | 0 | +307,250 | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | 0.01% | #201 | $40.0M | 300,365 | $77.0M | 691,670 | -391,305-56.57% | Reduce |
