| FMR LLC |
| 0.02% | 0.02% | #67 | $525.9M | 14.1M | $438.9M | 13.2M | +937,328+7.12% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #112 | $331.5M | 8.9M | $281.3M | 8.4M | +451,127+5.34% | Add |
| Jupiter Topco LLC |
| 0.13% | — | #37 | $319.7M | 8.6M | $0 | 0 | +8.6M | New Buy |
| Capital Research Global Investors |
| 0.03% | 0.03% | #59 | $199.2M | 5.3M | $172.0M | 5.2M | +181,158+3.51% | Add |
| BAKER BROS. ADVISORS LP |
| 0.94% | 0.76% | #15 | $186.7M | 5.0M | $131.5M | 3.9M | +1.1M+26.95% | Add |
| STATE STREET CORP |
| 0.01% | <0.01% | #111 | $169.5M | 4.5M | $126.0M | 3.8M | +767,744+20.30% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #131 | $154.0M | 4.1M | $124.4M | 3.7M | +400,224+10.72% | Add |
| Logos Global Management LP |
| 4.81% | 5.74% | #2 | $111.8M | 3.0M | $115.0M | 3.5M | -450,000-13.04% | Reduce |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.14% | 0.15% | #36 | $101.2M | 2.7M | $94.1M | 2.8M | -108,109-3.83% | Reduce |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.06% | 0.6% | #11 | $101.2M | 2.7M | $51.0M | 1.5M | +1.2M+77.42% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | 0.01% | #114 | $90.4M | 2.4M | $83.3M | 2.5M | -75,122-3.00% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #91 | $82.3M | 2.2M | $43.8M | 1.3M | +891,582+67.76% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #126 | $72.0M | 1.9M | $43.0M | 1.6M | +351,138+22.22% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #83 | $61.9M | 1.7M | $44.4M | 1.3M | +327,803+24.58% | Add |
| ALLIANCEBERNSTEIN L.P. |
| 0.02% | <0.01% | #72 | $54.2M | 1.6M | $3.5M | 100,786 | +1.5M+1,514.83% | Add |
| Fiera Capital Corp |
| 0.2% | 0.29% | #27 | $53.9M | 1.4M | $84.2M | 2.5M | -1.1M-42.78% | Reduce |
| FEDERATED HERMES, INC. |
| 0.08% | 0.16% | #44 | $53.4M | 1.4M | $99.5M | 3.0M | -1.6M-52.07% | Reduce |
| GSK plc |
| 8.25% | 7.41% | #1 | $49.7M | 1.3M | $44.4M | 1.3M | 00.00% | Unchanged |
| BNP Paribas Asset Management Holding S.A. |
| 0.05% | — | #49 | $47.3M | 1.3M | $0 | 0 | +1.3M | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | 0.01% | #124 | $45.9M | 1.2M | $63.8M | 1.9M | -682,003-35.64% | Reduce |
| Candriam S.C.A. |
| 0.18% | 0.18% | #29 | $40.7M | 1.1M | $35.7M | 1.0M | +60,947+5.91% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #147 | $38.2M | 1.0M | $31.4M | 942,091 | +84,052+8.92% | Add |
| Sofinnova Investments, Inc. |
| 1.78% | 1.43% | #7 | $34.5M | 925,119 | $37.7M | 1.1M | -206,667-18.26% | Reduce |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.01% | — | #77 | $33.2M | 891,608 | $0 | 0 | +891,608 | New Buy |
| Fisher Asset Management, LLC |
| 0.01% | 0.01% | #85 | $31.7M | 851,306 | $29.4M | 882,699 | -31,393-3.56% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #173 | $30.6M | 821,612 | $24.8M | 745,593 | +76,019+10.20% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #129 | $30.0M | 804,118 | $24.5M | 734,121 | +69,997+9.53% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #127 | $28.1M | 754,888 | $23.8M | 715,527 | +39,361+5.50% | Add |
| Pictet Asset Management Holding SA |
| 0.03% | 0.03% | #62 | $26.6M | 712,674 | $23.9M | 715,906 | -3,232-0.45% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #138 | $24.5M | 656,721 | $25.4M | 762,548 | -105,827-13.88% | Reduce |
| Nuveen, LLC |
| 0.01% | <0.01% | #103 | $23.9M | 640,257 | $14.9M | 448,273 | +191,984+42.83% | Add |
| Redmile Group, LLC |
| 1.6% | 1.15% | #8 | $23.9M | 640,202 | $17.4M | 521,117 | +119,085+22.85% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | <0.01% | #110 | $23.1M | 621,025 | $18.7M | 561,563 | +59,462+10.59% | Add |
| Qube Research & Technologies Ltd |
| 0.02% | 0.02% | #71 | $22.1M | 592,473 | $19.5M | 584,033 | +8,440+1.45% | Add |
| Aberdeen Group plc |
| 0.03% | 0.03% | #57 | $20.9M | 560,934 | $18.2M | 545,631 | +15,303+2.80% | Add |
| NEW YORK STATE COMMON RETIREMENT FUND |
| 0.02% | 0.02% | #65 | $18.7M | 501,990 | $17.2M | 515,445 | -13,455-2.61% | Reduce |
| DAFNA Capital Management LLC |
| 3.53% | 3.61% | #3 | $18.5M | 497,240 | $15.9M | 476,740 | +20,500+4.30% | Add |
| Sio Capital Management, LLC |
| 2.96% | — | #4 | $17.9M | 480,383 | $0 | 0 | +480,383 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #172 | $17.8M | 476,448 | $8.4M | 252,009 | +224,439+89.06% | Add |
| TANG CAPITAL MANAGEMENT LLC |
| 0.76% | 0.76% | #16 | $16.8M | 450,000 | $15.0M | 450,000 | 00.00% | Unchanged |
| Affinity Asset Advisors, LLC |
| 0.67% | — | #18 | $14.9M | 400,000 | $0 | 0 | +400,000 | New Buy |
| Walleye Capital LLC |
| 0.05% | — | #48 | $14.4M | 386,183 | $0 | 0 | +386,183 | New Buy |
| RTW INVESTMENTS, LP |
| 0.12% | — | #39 | $13.8M | 370,370 | $0 | 0 | +370,370 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #168 | $13.7M | 366,738 | $25.8M | 773,100 | -406,362-52.56% | Reduce |
| Rhenman & Partners Asset Management AB |
| 1.21% | 1.05% | #10 | $12.8M | 343,800 | $8.5M | 255,500 | +88,300+34.56% | Add |
| BIT Capital GmbH |
| 0.34% | — | #21 | $11.6M | 311,333 | $0 | 0 | +311,333 | New Buy |
| GENERAL AMERICAN INVESTORS CO INC |
| 0.68% | 0.61% | #17 | $11.5M | 308,240 | $9.3M | 280,261 | +27,979+9.98% | Add |
| FIRST TRUST ADVISORS LP |
| 0.01% | <0.01% | #97 | $11.4M | 306,729 | $1.6M | 46,687 | +260,042+556.99% | Add |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #160 | $11.1M | 297,848 | $8.1M | 243,328 | +54,520+22.41% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | 0.01% | #81 | $11.1M | 297,565 | $6.9M | 208,345 | +89,220+42.82% | Add |
