| Caligan Partners LP |
| 0.27% | 0.33% | #3 | $5.7M | 923,910 | $4.9M | 923,910 | 00.00% | Unchanged |
| CANNELL CAPITAL LLC |
| 3.22% | 2.28% | #1 | $4.8M | 783,923 | $3.6M | 685,123 | +98,800+14.42% | Add |
| Affinity Asset Advisors, LLC |
| 0.2% | 0.19% | #4 | $4.3M | 707,338 | $3.7M | 707,338 | 00.00% | Unchanged |
| Velan Capital Investment Management LP |
| 1.76% | 1.56% | #2 | $2.9M | 471,559 | $2.5M | 471,559 | 00.00% | Unchanged |
| ARMISTICE CAPITAL, LLC |
| 0.03% | 0.05% | #7 | $2.6M | 426,304 | $2.7M | 518,181 | -91,877-17.73% | Reduce |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.02% | 0.02% | #9 | $1.7M | 280,734 | $1.5M | 280,734 | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #27 | $1.7M | 279,310 | $998,530 | 188,758 | +90,552+47.97% | Add |
| Mariner, LLC |
| <0.01% | <0.01% | #13 | $1.3M | 207,230 | $129,838 | 24,544 | +182,686+744.32% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #26 | $845,656 | 138,160 | $734,965 | 138,917 | -757-0.54% | Reduce |
| Stonepine Capital Management, LLC |
| 0.08% | 0.21% | #6 | $530,502 | 88,417 | $527,598 | 99,735 | -11,318-11.35% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #33 | $454,986 | 74,344 | $203,945 | 38,553 | +35,791+92.84% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #24 | $429,459 | 70,173 | $344,384 | 65,101 | +5,072+7.79% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #19 | $249,849 | 40,825 | $268,002 | 50,662 | -9,837-19.42% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #34 | $176,966 | 28,916 | $152,966 | 28,916 | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #29 | $165,216 | 26,996 | $167,058 | 31,580 | -4,584-14.52% | Reduce |
| DAFNA Capital Management LLC |
| 0.03% | 0.18% | #8 | $145,350 | 23,750 | $813,136 | 153,712 | -129,962-84.55% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #32 | $144,762 | 23,654 | $260,327 | 49,211 | -25,557-51.93% | Reduce |
| Verdad Advisers, LP |
| 0.14% | 0.07% | #5 | $141,182 | 23,069 | $63,998 | 12,098 | +10,971+90.68% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #18 | $133,226 | 21,769 | $171,184 | 32,360 | -10,591-32.73% | Reduce |
| Legacy Trust |
| 0.02% | 0.02% | #10 | $101,494 | 16,584 | $91,168 | 17,234 | -650-3.77% | Reduce |
| FIFTH THIRD BANCORP |
| <0.01% | — | #23 | $85,680 | 14,000 | $0 | 0 | +14,000 | New Buy |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #31 | $84,995 | 13,888 | $0 | 0 | +13,888 | New Buy |
| XTX Topco Ltd |
| <0.01% | — | #14 | $83,985 | 13,723 | $0 | 0 | +13,723 | New Buy |
| TWO SIGMA SECURITIES, LLC |
| 0.01% | — | #11 | $79,835 | 13,045 | $0 | 0 | +13,045 | New Buy |
| HRT FINANCIAL LP |
| <0.01% | — | #21 | $79,701 | 13,023 | $0 | 0 | +13,023 | New Buy |
| BECK MACK & OLIVER LLC |
| <0.01% | <0.01% | #12 | $73,440 | 12,000 | $63,480 | 12,000 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #35 | $37,155 | 6,071 | $22,588 | 4,270 | +1,801+42.18% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #38 | $19,590 | 3,201 | $93,475 | 21,688 | -18,487-85.24% | Reduce |
| Capital Analysts, LLC |
| <0.01% | <0.01% | #17 | $9,180 | 1,500 | $12,000 | 1,500 | 00.00% | Unchanged |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #37 | $5,275 | 862 | $4,560 | 862 | 00.00% | Unchanged |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #39 | $5,000 | 764 | $5,000 | 954 | -190-19.92% | Reduce |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #25 | $3,758 | 614 | $4,528 | 856 | -242-28.27% | Reduce |
| Salomon & Ludwin, LLC |
| <0.01% | <0.01% | #22 | $1,586 | 290 | $1,586 | 290 | 00.00% | Unchanged |
| Allied Private Wealth LLC |
| <0.01% | — | #15 | $1,337 | 202 | $0 | 0 | +202 | New Buy |
| New England Capital Financial Advisors LLC |
| <0.01% | <0.01% | #16 | $1,224 | 200 | $1,058 | 200 | 00.00% | Unchanged |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC |
| <0.01% | <0.01% | #28 | $1,040 | 175 | $961 | 175 | 00.00% | Unchanged |
| Fortitude Family Office, LLC |
| <0.01% | <0.01% | #20 | $777 | 127 | $672 | 127 | 00.00% | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #40 | $673 | 110 | $582 | 110 | 00.00% | Unchanged |
| PNC FINANCIAL SERVICES GROUP, INC. |
| <0.01% | <0.01% | #41 | $624 | 102 | $540 | 102 | 00.00% | Unchanged |
| BARCLAYS PLC |
| <0.01% | — | #42 | $392 | 64 | $0 | 0 | +64 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #44 | $306 | 47 | $224 | 47 | 00.00% | Unchanged |
| Ameritas Advisory Services, LLC |
| <0.01% | — | #36 | $184 | 30 | $0 | 0 | +30 | New Buy |
| JONES FINANCIAL COMPANIES LLLP |
| <0.01% | <0.01% | #43 | $178 | 26 | $114 | 26 | 00.00% | Unchanged |
| VALLEY NATIONAL ADVISERS INC |
| <0.01% | — | #30 | $153 | 25 | $0 | 0 | +25 | New Buy |
