| FMR LLC |
| 0.03% | 0.03% | #80 | $799.3M | 8.2M | $651.9M | 7.8M | +432,207+5.56% | Add |
| BlackRock, Inc. |
| 0.01% | <0.01% | #137 | $402.0M | 4.1M | $266.5M | 3.2M | +948,119+29.86% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.25% | 0.07% | #45 | $379.0M | 3.9M | $108.4M | 1.3M | +2.6M+200.92% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.05% | 0.04% | #73 | $314.8M | 3.2M | $217.8M | 2.6M | +634,099+24.43% | Add |
| Fairmount Funds Management LLC |
| 16.35% | 15.38% | #2 | $247.3M | 2.5M | $212.9M | 2.5M | 00.00% | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.01% | #88 | $245.2M | 2.5M | $96.3M | 1.1M | +1.4M+119.27% | Add |
| STATE STREET CORP |
| 0.01% | <0.01% | #131 | $229.8M | 2.4M | $117.4M | 1.4M | +958,527+68.52% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #152 | $210.5M | 2.2M | $170.5M | 2.0M | +128,319+6.32% | Add |
| Avidity Partners Management LP |
| 32.85% | 35.76% | #1 | $205.1M | 2.1M | $176.6M | 2.1M | 00.00% | Unchanged |
| Octagon Capital Advisors LP |
| 16.14% | 18.08% | #3 | $179.5M | 1.8M | $163.4M | 1.9M | -105,000-5.39% | Reduce |
| TCG Crossover Management, LLC |
| 3.93% | 4.03% | #6 | $163.4M | 1.7M | $140.7M | 1.7M | 00.00% | Unchanged |
| FRED ALGER MANAGEMENT, LLC |
| 0.42% | 0.43% | #37 | $127.0M | 1.3M | $97.5M | 1.2M | +140,570+12.10% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #133 | $122.7M | 1.3M | $76.9M | 916,211 | +342,291+37.36% | Add |
| Venrock Adviser, LLC |
| 3.49% | 3.7% | #8 | $115.0M | 1.2M | $99.0M | 1.2M | 00.00% | Unchanged |
| UBS Group AG |
| 0.01% | 0.01% | #101 | $111.2M | 1.1M | $65.6M | 781,282 | +358,978+45.95% | Add |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.14% | 1.01% | #25 | $109.7M | 1.1M | $85.6M | 1.0M | +105,500+10.35% | Add |
| CITADEL ADVISORS LLC |
| 0.01% | 0.02% | #105 | $100.0M | 1.0M | $138.4M | 1.6M | -623,072-37.79% | Reduce |
| JENNISON ASSOCIATES LLC |
| 0.06% | 0.03% | #71 | $99.6M | 1.0M | $40.7M | 485,136 | +536,627+110.61% | Add |
| Polar Capital Holdings Plc |
| 0.23% | 0.32% | #47 | $99.3M | 1.0M | $90.3M | 1.1M | -57,283-5.32% | Reduce |
| FRANKLIN RESOURCES INC |
| 0.02% | 0.02% | #94 | $94.5M | 968,983 | $81.2M | 968,182 | +801+0.08% | Add |
| BAKER BROS. ADVISORS LP |
| 0.42% | 0.41% | #38 | $83.1M | 852,164 | $71.5M | 852,164 | 00.00% | Unchanged |
| Logos Global Management LP |
| 3.36% | 1.68% | #9 | $78.0M | 800,000 | $33.6M | 400,000 | +400,000+100.00% | Add |
| Cormorant Asset Management, LP |
| 3.71% | 4% | #7 | $73.1M | 750,000 | $79.7M | 950,000 | -200,000-21.05% | Reduce |
| ALLIANCEBERNSTEIN L.P. |
| 0.02% | 0.01% | #90 | $70.0M | 834,150 | $38.2M | 926,071 | -91,921-9.93% | Reduce |
| BRAIDWELL LP |
| 2.14% | 2.52% | #15 | $58.0M | 594,562 | $75.5M | 899,364 | -304,802-33.89% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #171 | $55.6M | 570,115 | $29.3M | 349,381 | +220,734+63.18% | Add |
| AMERIPRISE FINANCIAL INC |
| 0.01% | 0.01% | #110 | $51.9M | 531,999 | $30.1M | 358,470 | +173,529+48.41% | Add |
| Woodline Partners LP |
| 0.15% | 0.14% | #58 | $48.8M | 500,548 | $36.4M | 433,457 | +67,091+15.48% | Add |
| BARCLAYS PLC |
| 0.01% | 0.01% | #122 | $42.1M | 431,753 | $31.9M | 379,606 | +52,147+13.74% | Add |
| LORD, ABBETT & CO. LLC |
| 0.12% | 0.08% | #60 | $41.2M | 422,185 | $25.1M | 299,210 | +122,975+41.10% | Add |
| MPM BioImpact LLC |
| 2.5% | 2.75% | #14 | $40.9M | 420,002 | $35.6M | 423,982 | -3,980-0.94% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #149 | $40.1M | 411,791 | $25.5M | 303,752 | +108,039+35.57% | Add |
| Affinity Asset Advisors, LLC |
| 1.76% | 1.73% | #18 | $39.0M | 400,000 | $33.6M | 400,000 | 00.00% | Unchanged |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 3.95% | 5.61% | #5 | $38.0M | 390,000 | $54.9M | 654,746 | -264,746-40.43% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | 0.01% | #163 | $37.3M | 382,161 | $46.0M | 548,010 | -165,849-30.26% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #147 | $35.7M | 365,963 | $25.6M | 305,440 | +60,523+19.82% | Add |
| Bain Capital Life Sciences Investors, LLC |
| 2.1% | 2.74% | #17 | $35.3M | 362,470 | $30.4M | 362,470 | 00.00% | Unchanged |
| Spruce Street Capital LP |
| 6.79% | 7.53% | #4 | $34.6M | 354,816 | $31.3M | 373,274 | -18,458-4.94% | Reduce |
| Vivo Capital, LLC |
| 3.15% | 2.47% | #10 | $34.5M | 353,998 | $29.7M | 353,998 | 00.00% | Unchanged |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #139 | $31.3M | 321,503 | $27.3M | 325,440 | -3,937-1.21% | Reduce |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.1% | — | #61 | $30.7M | 314,914 | $0 | 0 | +314,914 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #134 | $29.5M | 302,482 | $21.0M | 249,679 | +52,803+21.15% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.17% | 0.2% | #56 | $28.8M | 295,266 | $26.6M | 317,312 | -22,046-6.95% | Reduce |
| First Turn Management, LLC |
| 2.98% | 2.07% | #11 | $27.9M | 285,771 | $18.5M | 220,921 | +64,850+29.35% | Add |
| Assenagon Asset Management S.A. |
| 0.03% | — | #82 | $27.4M | 280,649 | $0 | 0 | +280,649 | New Buy |
| TANG CAPITAL MANAGEMENT LLC |
| 1.17% | 1.13% | #24 | $25.8M | 264,692 | $22.2M | 264,692 | 00.00% | Unchanged |
| Artisan Partners Limited Partnership |
| 0.04% | 0.05% | #78 | $25.2M | 258,269 | $32.1M | 382,121 | -123,852-32.41% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #186 | $25.0M | 256,833 | $15.8M | 188,779 | +68,054+36.05% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #156 | $25.0M | 256,393 | $15.8M | 188,412 | +67,981+36.08% | Add |
| RTW INVESTMENTS, LP |
| 0.21% | 0.21% | #50 | $24.2M | 248,063 | $20.8M | 248,063 | 00.00% | Unchanged |
