| FMR LLC |
| 0.04% | 0.02% | #46 | $840.2M | 29.1M | $464.9M | 25.7M | +3.4M+13.22% | Add |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 2.45% | 1.64% | #12 | $235.0M | 8.1M | $139.1M | 7.7M | +450,000+5.85% | Add |
| MONTANOVA CAPITAL, LLC |
| 3.73% | 3.5% | #8 | $204.2M | 7.1M | $137.1M | 7.6M | -511,029-6.74% | Reduce |
| Hillhouse Capital Advisors, Ltd. |
| 20.77% | 6.47% | #1 | $172.8M | 6.0M | $108.3M | 6.0M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #108 | $136.5M | 4.7M | $84.7M | 4.7M | +41,991+0.90% | Add |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.42% | 0.44% | #18 | $127.9M | 4.4M | $104.3M | 5.8M | -1.3M-23.14% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #68 | $105.8M | 3.7M | $26.5M | 1.5M | +2.2M+150.14% | Add |
| Point72 Asset Management, L.P. |
| 0.1% | 0.09% | #30 | $88.8M | 3.1M | $70.3M | 3.9M | -809,893-20.84% | Reduce |
| Kynam Capital Management, LP |
| 4.79% | 1.76% | #5 | $86.7M | 3.0M | $28.5M | 1.6M | +1.4M+90.40% | Add |
| Assenagon Asset Management S.A. |
| 0.07% | — | #37 | $55.3M | 1.9M | $0 | 0 | +1.9M | New Buy |
| Artisan Partners Limited Partnership |
| 0.07% | 0.07% | #34 | $45.0M | 1.6M | $40.8M | 2.3M | -695,047-30.83% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #127 | $43.3M | 1.5M | $27.1M | 1.5M | +332+0.02% | Add |
| Capital International Investors |
| 0.01% | <0.01% | #69 | $41.0M | 1.4M | $11.7M | 647,850 | +772,804+119.29% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #105 | $40.3M | 1.4M | $14.1M | 431,076 | +963,455+223.50% | Add |
| Soleus Capital Management, L.P. |
| 1.2% | — | #13 | $34.8M | 1.2M | $0 | 0 | +1.2M | New Buy |
| Davern Capital Partners, LP |
| 5.87% | 6.52% | #4 | $34.4M | 1.2M | $23.8M | 1.3M | -123,226-9.37% | Reduce |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.19% | — | #25 | $33.5M | 1.2M | $0 | 0 | +1.2M | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.04% | 0.01% | #44 | $28.9M | 1.0M | $9.4M | 521,800 | +478,400+91.68% | Add |
| Ghisallo Capital Management LLC |
| 0.17% | — | #27 | $28.9M | 1.0M | $0 | 0 | +1.0M | New Buy |
| MATTHEWS INTERNATIONAL CAPITAL MANAGEMENT LLC |
| 8.89% | 6.8% | #3 | $26.5M | 917,266 | $16.7M | 925,920 | -8,654-0.93% | Reduce |
| JOHNSON & JOHNSON |
| 2.95% | 2.26% | #11 | $23.5M | 814,586 | $14.7M | 814,586 | 00.00% | Unchanged |
| IvyRock Asset Management (HK) Ltd |
| 13.08% | 8.17% | #2 | $23.1M | 801,000 | $14.5M | 804,000 | -3,000-0.37% | Reduce |
| EcoR1 Capital, LLC |
| 1.12% | — | #14 | $23.1M | 800,000 | $0 | 0 | +800,000 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #130 | $22.5M | 766,364 | $5.0M | 288,103 | +478,261+166.00% | Add |
| Squarepoint Ops LLC |
| 0.02% | 0.01% | #56 | $22.2M | 769,252 | $8.7M | 479,480 | +289,772+60.43% | Add |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.01% | <0.01% | #67 | $21.9M | 759,994 | $7.4M | 406,901 | +353,093+86.78% | Add |
| Woodline Partners LP |
| 0.06% | 0.01% | #40 | $19.1M | 663,086 | $3.7M | 205,870 | +457,216+222.09% | Add |
| Triata Capital Ltd |
| 3.09% | 2.07% | #10 | $18.2M | 629,914 | $11.4M | 629,914 | 00.00% | Unchanged |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | — | #57 | $17.3M | 600,000 | $0 | 0 | +600,000 | New Buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | <0.01% | #77 | $16.6M | 574,685 | $10.4M | 574,898 | -213-0.04% | Reduce |
| Elmind Capital, LP |
| 4.14% | — | #6 | $16.5M | 570,569 | $0 | 0 | +570,569 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #144 | $16.2M | 563,489 | $9.9M | 550,051 | +13,438+2.44% | Add |
| Candriam S.C.A. |
| 0.07% | 0.03% | #38 | $14.6M | 504,924 | $5.7M | 261,815 | +243,109+92.86% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #111 | $14.5M | 502,466 | $5.5M | 305,214 | +197,252+64.63% | Add |
| CenterBook Partners LP |
| 0.64% | 0.2% | #15 | $13.1M | 452,907 | $3.7M | 204,603 | +248,304+121.36% | Add |
| ArrowMark Colorado Holdings LLC |
| 0.44% | 0.35% | #17 | $10.5M | 362,781 | $13.2M | 727,144 | -364,363-50.11% | Reduce |
| Hudson Bay Capital Management LP |
| 0.03% | 0.06% | #54 | $9.8M | 340,000 | $18.6M | 1.0M | -686,551-66.88% | Reduce |
| Alyeska Investment Group, L.P. |
| 0.02% | <0.01% | #59 | $8.9M | 307,474 | $190,054 | 10,506 | +296,968+2,826.65% | Add |
| Empire Life Investments Inc. |
| 0.48% | 0.35% | #16 | $8.6M | 296,586 | $5.7M | 300,958 | -4,372-1.45% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #140 | $8.3M | 288,941 | $12.3M | 678,480 | -389,539-57.41% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #142 | $7.9M | 274,856 | $5.1M | 280,226 | -5,370-1.92% | Reduce |
| Resolute Capital Asset Partners LLC |
| 3.22% | — | #9 | $7.5M | 260,871 | $0 | 0 | +260,871 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #89 | $7.3M | 251,449 | $4.2M | 234,533 | +16,916+7.21% | Add |
| Burkehill Global Management, LP |
| 0.26% | — | #21 | $7.2M | 250,000 | $0 | 0 | +250,000 | New Buy |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #120 | $7.2M | 249,767 | $1.4M | 75,439 | +174,328+231.08% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #158 | $7.2M | 247,902 | $276,686 | 15,295 | +232,607+1,520.80% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #157 | $7.0M | 241,700 | $2.6M | 142,300 | +99,400+69.85% | Add |
| Tidal Investments LLC |
| 0.01% | 0.01% | #66 | $6.9M | 240,476 | $3.2M | 179,453 | +61,023+34.01% | Add |
| HSBC HOLDINGS PLC |
| <0.01% | <0.01% | #94 | $6.8M | 236,204 | $4.0M | 221,475 | +14,729+6.65% | Add |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | — | #131 | $6.6M | 228,229 | $0 | 0 | +228,229 | New Buy |
