| BAKER BROS. ADVISORS LP |
| 4.15% | 5.19% | #10 | $828.2M | 7.9M | $903.5M | 7.9M | 00.00% | Unchanged |
| Avoro Capital Advisors LLC |
| 3.19% | 3.82% | #13 | $355.7M | 3.4M | $388.3M | 3.6M | -175,000-4.90% | Reduce |
| RTW INVESTMENTS, LP |
| 2.95% | 3.45% | #14 | $345.8M | 3.3M | $346.9M | 3.0M | +265,282+8.73% | Add |
| PERCEPTIVE ADVISORS LLC |
| 5.02% | 6.97% | #8 | $334.5M | 3.2M | $356.9M | 3.1M | +70,000+2.24% | Add |
| BlackRock, Inc. |
| <0.01% | 0.01% | #149 | $315.8M | 3.0M | $309.5M | 2.7M | +307,253+11.33% | Add |
| STATE STREET CORP |
| 0.01% | 0.01% | #136 | $204.6M | 2.0M | $173.3M | 1.5M | +436,599+28.75% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | 0.01% | #157 | $196.1M | 1.9M | $203.5M | 1.8M | +91,243+5.12% | Add |
| NEA Management Company, LLC |
| 11.27% | 14.83% | #2 | $179.0M | 1.7M | $260.9M | 2.3M | -575,000-25.16% | Reduce |
| Soleus Capital Management, L.P. |
| 6.14% | 5.94% | #4 | $178.3M | 1.7M | $146.6M | 1.3M | +419,940+32.70% | Add |
| BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.01% | #114 | $153.9M | 1.5M | $81.5M | 714,329 | +756,978+105.97% | Add |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.58% | 2.31% | #17 | $151.8M | 1.5M | $195.6M | 1.7M | -262,986-15.34% | Reduce |
| MORGAN STANLEY |
| 0.01% | <0.01% | #126 | $139.6M | 1.3M | $74.7M | 1.5M | -178,307-11.79% | Reduce |
| TANG CAPITAL MANAGEMENT LLC |
| 6.25% | 6.09% | #3 | $137.5M | 1.3M | $119.8M | 1.1M | +264,594+25.20% | Add |
| TORONTO DOMINION BANK |
| 0.15% | 0.14% | #44 | $131.7M | 1.3M | $100.8M | 882,758 | +376,000+42.59% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #135 | $116.3M | 1.1M | $101.7M | 891,070 | +220,592+24.76% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.02% | #112 | $107.3M | 1.0M | $146.1M | 1.3M | -253,979-19.84% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.02% | 0.01% | #102 | $94.8M | 906,595 | $49.0M | 428,952 | +477,643+111.35% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #121 | $91.1M | 870,449 | $87.3M | 764,975 | +105,474+13.79% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.01% | 0.01% | #128 | $89.5M | 855,878 | $79.3M | 694,697 | +161,181+23.20% | Add |
| Point72 Asset Management, L.P. |
| 0.08% | 0.05% | #63 | $68.1M | 650,916 | $36.5M | 320,024 | +330,892+103.40% | Add |
| Hood River Capital Management LLC |
| 0.48% | — | #28 | $65.7M | 628,411 | $0 | 0 | +628,411 | New Buy |
| ALLIANCEBERNSTEIN L.P. |
| 0.02% | 0.01% | #95 | $60.6M | 530,922 | $46.3M | 464,328 | +66,594+14.34% | Add |
| FMR LLC |
| <0.01% | <0.01% | #174 | $57.4M | 548,983 | $4.2M | 36,360 | +512,623+1,409.85% | Add |
| APIS CAPITAL ADVISORS, LLC |
| 5.48% | 9.07% | #6 | $56.3M | 538,000 | $58.8M | 515,000 | +23,000+4.47% | Add |
| Holocene Advisors, LP |
| 0.13% | 0.1% | #52 | $55.8M | 533,147 | $42.2M | 369,979 | +163,168+44.10% | Add |
| UBS Group AG |
| 0.01% | <0.01% | #129 | $54.5M | 520,946 | $25.1M | 220,163 | +300,783+136.62% | Add |
| FULLER & THALER ASSET MANAGEMENT, INC. |
| 0.15% | — | #46 | $53.8M | 514,396 | $0 | 0 | +514,396 | New Buy |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 5.45% | 4.17% | #7 | $52.4M | 500,996 | $40.9M | 357,903 | +143,093+39.98% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.02% | 0.01% | #87 | $51.7M | 494,350 | $21.9M | 191,999 | +302,351+157.48% | Add |
| Caption Management, LLC |
| 0.24% | 0.4% | #40 | $51.5M | 492,100 | $68.5M | 600,000 | -107,900-17.98% | Reduce |
| Artisan Partners Limited Partnership |
| 0.08% | 0.08% | #62 | $48.3M | 461,591 | $52.2M | 457,070 | +4,521+0.99% | Add |
| AMERICAN CENTURY COMPANIES INC |
| 0.02% | — | #94 | $46.5M | 444,909 | $0 | 0 | +444,909 | New Buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.14% | — | #47 | $43.7M | 417,816 | $0 | 0 | +417,816 | New Buy |
| Boxer Capital Management, LLC |
| 3.28% | 3.37% | #12 | $43.6M | 416,530 | $25.7M | 225,000 | +191,530+85.12% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #166 | $40.8M | 389,600 | $33.1M | 290,416 | +99,184+34.15% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #188 | $39.8M | 380,013 | $33.2M | 291,171 | +88,842+30.51% | Add |
| Saturn V Capital Management LP |
| 5.55% | 5.83% | #5 | $38.7M | 370,318 | $32.2M | 281,904 | +88,414+31.36% | Add |
| JENNISON ASSOCIATES LLC |
| 0.02% | 0.02% | #91 | $37.6M | 358,972 | $26.4M | 231,140 | +127,832+55.31% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #156 | $37.3M | 356,919 | $36.4M | 318,766 | +38,153+11.97% | Add |
| LORD, ABBETT & CO. LLC |
| 0.11% | 0.16% | #56 | $36.9M | 352,372 | $50.1M | 439,221 | -86,849-19.77% | Reduce |
| First Turn Management, LLC |
| 3.68% | 2.69% | #11 | $34.4M | 329,101 | $24.0M | 210,578 | +118,523+56.28% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | 0.01% | #155 | $33.6M | 320,893 | $33.5M | 293,892 | +27,001+9.19% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.18% | 0.2% | #43 | $31.8M | 303,860 | $27.6M | 241,549 | +62,311+25.80% | Add |
| FRANKLIN RESOURCES INC |
| 0.01% | <0.01% | #132 | $31.2M | 298,047 | $1.9M | 17,034 | +281,013+1,649.72% | Add |
| PFIZER INC |
| 17.35% | 13.13% | #1 | $29.6M | 295,652 | $31.3M | 295,652 | 00.00% | Unchanged |
| VOYA INVESTMENT MANAGEMENT LLC |
| 0.03% | 0.02% | #84 | $29.2M | 278,827 | $15.2M | 133,191 | +145,636+109.34% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #131 | $29.1M | 277,749 | $28.9M | 253,366 | +24,383+9.62% | Add |
| CAPITOLIS LIQUID GLOBAL MARKETS LLC |
| 0.13% | 0.23% | #51 | $29.0M | 277,100 | $36.1M | 316,500 | -39,400-12.45% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | 0.01% | #170 | $25.9M | 247,100 | $32.1M | 280,806 | -33,706-12.00% | Reduce |
| Focus Partners Wealth |
| 0.02% | 0.03% | #86 | $24.3M | 232,559 | $26.6M | 233,390 | -831-0.36% | Reduce |
