| Knoll Capital Management, LLC |
| 5.97% | 3.43% | #1 | $10.4M | 5.9M | $6.5M | 5.9M | 00.00% | Unchanged |
| BVF INC/IL |
| 0.11% | — | #2 | $4.3M | 2.4M | $0 | 0 | +2.4M | New Buy |
| Siren, L.L.C. |
| 0.03% | — | #5 | $1.3M | 736,457 | $0 | 0 | +736,457 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #12 | $652,859 | 368,847 | $525,521 | 473,442 | -104,595-22.09% | Reduce |
| Parkman Healthcare Partners LLC |
| 0.05% | 0.03% | #4 | $485,860 | 274,497 | $320,424 | 288,670 | -14,173-4.91% | Reduce |
| PNC FINANCIAL SERVICES GROUP, INC. |
| <0.01% | <0.01% | #15 | $483,265 | 273,031 | $11,100 | 10,000 | +263,031+2,630.31% | Add |
| Seven Fleet Capital Management LP |
| 0.06% | 0.07% | #3 | $338,697 | 191,354 | $228,152 | 205,542 | -14,188-6.90% | Reduce |
| HighTower Advisors, LLC |
| <0.01% | <0.01% | #17 | $132,935 | 74,573 | $40,881 | 36,830 | +37,743+102.48% | Add |
| HRT FINANCIAL LP |
| <0.01% | <0.01% | #16 | $128,300 | 72,486 | $17,000 | 15,492 | +56,994+367.89% | Add |
| Schonfeld Strategic Advisors LLC |
| <0.01% | <0.01% | #14 | $104,201 | 58,871 | $61,296 | 55,223 | +3,648+6.61% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #20 | $86,560 | 48,904 | $272,590 | 245,577 | -196,673-80.09% | Reduce |
| TWO SIGMA SECURITIES, LLC |
| 0.01% | — | #7 | $86,010 | 48,593 | $0 | 0 | +48,593 | New Buy |
| SIGNATURE ESTATE & INVESTMENT ADVISORS LLC |
| <0.01% | <0.01% | #11 | $83,771 | 47,328 | $52,534 | 47,328 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #21 | $67,457 | 40,883 | $7,150 | 7,150 | +33,733+471.79% | Add |
| Virtu Financial LLC |
| <0.01% | — | #10 | $65,350 | 36,921 | $0 | 0 | +36,921 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #23 | $52,937 | 29,908 | $23,460 | 21,136 | +8,772+41.50% | Add |
| DIADEMA PARTNERS LP |
| 0.01% | <0.01% | #8 | $41,170 | 23,260 | $25,819 | 23,260 | 00.00% | Unchanged |
| XTX Topco Ltd |
| <0.01% | <0.01% | #13 | $36,389 | 20,559 | $146,100 | 131,622 | -111,063-84.38% | Reduce |
| Gem Investment Advisors, LLC |
| 0.02% | 0.04% | #6 | $33,869 | 19,135 | $37,122 | 19,135 | 00.00% | Unchanged |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #24 | $30,676 | 17,331 | $36,536 | 32,915 | -15,584-47.35% | Reduce |
| SIMPLEX TRADING, LLC |
| <0.01% | — | #18 | $27,785 | 15,698 | $0 | 0 | +15,698 | New Buy |
| SG Americas Securities, LLC |
| <0.01% | — | #19 | $24,626 | 13,913 | $0 | 0 | +13,913 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #22 | $22,520 | 12,723 | $3,565 | 3,212 | +9,511+296.11% | Add |
| Persistent Asset Partners Ltd |
| <0.01% | <0.01% | #9 | $10,409 | 5,881 | $6,528 | 5,881 | 00.00% | Unchanged |
| MORGAN STANLEY |
| <0.01% | — | #27 | $885 | 500 | $0 | 0 | +500 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | — | #25 | $708 | 400 | $0 | 0 | +400 | New Buy |
| GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #26 | $90 | 51 | $57 | 51 | 00.00% | Unchanged |
