| FMR LLC |
| 0.04% | 0.04% | #75 | $989.7M | 18.0M | $847.7M | 17.2M | +752,089+4.36% | Add |
| Siren, L.L.C. |
| 10.66% | 14.75% | #3 | $526.6M | 9.6M | $532.2M | 10.8M | -1.3M-11.55% | Reduce |
| BlackRock, Inc. |
| 0.01% | 0.01% | #128 | $522.2M | 9.5M | $367.2M | 7.5M | +2.0M+27.11% | Add |
| Samsara BioCapital, LLC |
| 31.16% | 32.95% | #1 | $379.4M | 6.9M | $339.1M | 6.9M | 00.00% | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.04% | 0.03% | #81 | $373.7M | 6.8M | $305.1M | 6.2M | +588,219+9.48% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.06% | 0.06% | #60 | $370.0M | 6.7M | $330.2M | 6.7M | +9,430+0.14% | Add |
| Orbis Allan Gray Ltd |
| 1.12% | 0.87% | #18 | $326.3M | 5.9M | $205.5M | 4.2M | +1.8M+41.95% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | <0.01% | #146 | $262.2M | 4.8M | $191.3M | 3.9M | +876,533+22.53% | Add |
| STATE STREET CORP |
| 0.01% | 0.01% | #129 | $260.1M | 4.7M | $198.2M | 4.0M | +697,364+17.30% | Add |
| Redmile Group, LLC |
| 15.92% | 29.51% | #2 | $237.1M | 4.3M | $445.7M | 9.1M | -4.8M-52.45% | Reduce |
| NORGES BANK |
| 0.02% | 0.01% | #108 | $152.3M | 2.8M | $52.5M | 1.6M | +1.1M+69.58% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #124 | $151.5M | 2.8M | $105.7M | 2.1M | +604,751+28.14% | Add |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.05% | — | #74 | $143.4M | 2.6M | $0 | 0 | +2.6M | New Buy |
| Bellevue Group AG |
| 2.83% | 4.19% | #6 | $134.7M | 2.4M | $176.2M | 3.6M | -1.1M-31.66% | Reduce |
| JENNISON ASSOCIATES LLC |
| 0.08% | 0.11% | #57 | $129.7M | 2.4M | $164.2M | 3.3M | -981,905-29.39% | Reduce |
| Jupiter Topco LLC |
| 0.05% | — | #69 | $123.3M | 2.2M | $0 | 0 | +2.2M | New Buy |
| Hood River Capital Management LLC |
| 0.89% | 1.01% | #21 | $122.4M | 2.2M | $100.8M | 2.0M | +175,109+8.54% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.7% | 0.69% | #22 | $121.3M | 2.2M | $94.4M | 1.9M | +285,385+14.86% | Add |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 1.55% | 1.78% | #14 | $116.1M | 2.1M | $107.9M | 2.2M | -85,975-3.91% | Reduce |
| Polar Capital Holdings Plc |
| 0.24% | 0.35% | #34 | $103.3M | 1.9M | $97.5M | 2.0M | -105,048-5.30% | Reduce |
| Holocene Advisors, LP |
| 0.22% | 0.22% | #35 | $96.6M | 1.8M | $93.0M | 1.9M | -134,949-7.14% | Reduce |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.13% | 0.05% | #45 | $95.2M | 1.7M | $34.4M | 700,000 | +1.0M+147.34% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #160 | $84.6M | 1.5M | $22.5M | 604,002 | +934,774+154.76% | Add |
| Woodline Partners LP |
| 0.26% | 0.28% | #32 | $82.5M | 1.5M | $73.8M | 1.5M | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #137 | $77.6M | 1.4M | $69.4M | 1.4M | -206-0.01% | Reduce |
| Capital World Investors |
| 0.01% | 0.01% | #130 | $63.8M | 1.2M | $55.5M | 1.1M | +31,657+2.80% | Add |
| Clearbridge Investments, LLC |
| 0.05% | 0.03% | #72 | $58.3M | 1.1M | $34.0M | 691,418 | +368,358+53.28% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #188 | $56.5M | 1.0M | $35.5M | 721,744 | +305,613+42.34% | Add |
| BNP Paribas Asset Management Holding S.A. |
| 0.05% | — | #65 | $53.9M | 979,845 | $0 | 0 | +979,845 | New Buy |
| AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.02% | #92 | $53.6M | 975,197 | $34.8M | 707,101 | +268,096+37.91% | Add |
| NORTHERN TRUST CORP |
| 0.01% | <0.01% | #142 | $53.6M | 974,576 | $37.5M | 763,803 | +210,773+27.60% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #174 | $53.5M | 972,257 | $65.7M | 1.3M | -364,375-27.26% | Reduce |
| Pictet Asset Management Holding SA |
| 0.05% | 0.05% | #73 | $50.1M | 911,075 | $43.0M | 875,084 | +35,991+4.11% | Add |
| VOYA INVESTMENT MANAGEMENT LLC |
| 0.04% | 0.04% | #76 | $49.0M | 890,607 | $35.7M | 725,409 | +165,198+22.77% | Add |
| FRANKLIN RESOURCES INC |
| 0.01% | <0.01% | #116 | $48.3M | 878,726 | $1.3M | 26,882 | +851,844+3,168.83% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #140 | $47.5M | 864,286 | $34.5M | 701,011 | +163,275+23.29% | Add |
| Integral Health Asset Management, LLC |
| 1.63% | 1.18% | #12 | $41.3M | 750,000 | $24.6M | 500,000 | +250,000+50.00% | Add |
| FEDERATED HERMES, INC. |
| 0.06% | 0.06% | #62 | $40.4M | 734,513 | $39.2M | 797,913 | -63,400-7.95% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #120 | $40.2M | 730,083 | $29.0M | 589,048 | +141,035+23.94% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.02% | 0.02% | #97 | $39.5M | 717,512 | $35.6M | 723,875 | -6,363-0.88% | Reduce |
| Rock Springs Capital Management LP |
| 1.92% | 2.14% | #7 | $39.3M | 715,452 | $36.4M | 739,816 | -24,364-3.29% | Reduce |
| Casdin Capital, LLC |
| 1.83% | 1.3% | #9 | $36.6M | 665,000 | $17.2M | 350,000 | +315,000+90.00% | Add |
| Nuveen, LLC |
| 0.01% | 0.01% | #122 | $35.8M | 651,749 | $28.6M | 581,654 | +70,095+12.05% | Add |
| LOOMIS SAYLES & CO L P |
| 0.04% | 0.04% | #78 | $32.8M | 596,055 | $31.4M | 638,629 | -42,574-6.67% | Reduce |
| Ensign Peak Advisors, Inc |
| 0.05% | 0.07% | #68 | $31.8M | 579,052 | $35.3M | 717,253 | -138,201-19.27% | Reduce |
| Eagle Health Investments LP |
| 5.06% | 4.25% | #4 | $30.5M | 555,272 | $24.3M | 494,019 | +61,253+12.40% | Add |
| UBS Group AG |
| <0.01% | 0.01% | #171 | $28.1M | 511,170 | $33.4M | 679,784 | -168,614-24.80% | Reduce |
| Qube Research & Technologies Ltd |
| 0.02% | — | #93 | $25.5M | 463,730 | $0 | 0 | +463,730 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | 0.01% | #181 | $25.3M | 459,651 | $48.5M | 986,499 | -526,848-53.41% | Reduce |
| Fisher Asset Management, LLC |
| 0.01% | 0.01% | #133 | $24.2M | 439,447 | $22.5M | 458,017 | -18,570-4.05% | Reduce |
