| BlackRock, Inc. |
| 0.01% | <0.01% | #128 | $860.2M | 10.8M | $207.2M | 5.5M | +5.3M+96.54% | Add |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 3.08% | 1.86% | #10 | $666.9M | 8.4M | $326.7M | 8.7M | -291,000-3.36% | Reduce |
| Caligan Partners LP |
| 30.45% | 20.39% | #3 | $647.3M | 8.1M | $306.4M | 8.1M | 00.00% | Unchanged |
| FINDELL CAPITAL MANAGEMENT LLC |
| 53.91% | 39.26% | #1 | $382.9M | 4.8M | $134.1M | 3.6M | +1.3M+35.19% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | <0.01% | #180 | $250.3M | 3.1M | $110.5M | 2.9M | +212,238+7.25% | Add |
| STATE STREET CORP |
| 0.01% | <0.01% | #158 | $241.6M | 3.0M | $71.0M | 1.9M | +1.1M+61.05% | Add |
| Opaleye Management Inc. |
| 17.67% | 11.7% | #5 | $195.1M | 2.4M | $88.8M | 2.5M | -97,500-3.83% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #148 | $169.2M | 2.1M | $72.8M | 1.9M | +192,321+9.97% | Add |
| BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.01% | #140 | $158.8M | 2.0M | $86.3M | 2.3M | -296,226-12.95% | Reduce |
| CITADEL ADVISORS LLC |
| 0.02% | 0.01% | #111 | $155.1M | 1.9M | $72.3M | 1.9M | +30,686+1.60% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | <0.01% | #121 | $154.7M | 1.9M | $36.0M | 953,151 | +987,213+103.57% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.01% | 0.01% | #134 | $145.7M | 1.8M | $62.6M | 1.7M | +169,386+10.22% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | <0.01% | #177 | $122.2M | 1.5M | $23.9M | 632,625 | +899,526+142.19% | Add |
| Caprock Group, LLC |
| 2.15% | 1.25% | #11 | $112.4M | 1.4M | $51.6M | 1.4M | +42,524+3.11% | Add |
| MPM BioImpact LLC |
| 6.74% | 4.1% | #7 | $110.5M | 1.4M | $53.0M | 1.4M | -18,984-1.35% | Reduce |
| D. E. Shaw & Co., Inc. |
| 0.05% | 0.02% | #82 | $108.3M | 1.4M | $34.3M | 909,265 | +448,941+49.37% | Add |
| FULLER & THALER ASSET MANAGEMENT, INC. |
| 0.26% | — | #40 | $96.4M | 1.2M | $0 | 0 | +1.2M | New Buy |
| Buckley Capital Advisors, LLC |
| 37.81% | 32.1% | #2 | $77.9M | 973,244 | $44.7M | 1.2M | -210,400-17.78% | Reduce |
| JANE STREET GROUP, LLC |
| 0.01% | 0.01% | #165 | $77.7M | 974,541 | $49.9M | 1.3M | -347,543-26.29% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #161 | $76.5M | 958,892 | $30.6M | 811,990 | +146,902+18.09% | Add |
| FEDERATED HERMES, INC. |
| 0.09% | 0.03% | #68 | $65.1M | 816,187 | $16.6M | 438,767 | +377,420+86.02% | Add |
| NORTHERN TRUST CORP |
| 0.01% | <0.01% | #162 | $56.5M | 709,063 | $21.9M | 579,875 | +129,188+22.28% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | <0.01% | #159 | $53.7M | 674,033 | $21.0M | 557,200 | +116,833+20.97% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #224 | $52.5M | 658,441 | $22.9M | 1.0M | -348,266-34.59% | Reduce |
| Caption Management, LLC |
| 0.24% | 0.08% | #42 | $52.1M | 653,000 | $13.8M | 366,600 | +286,400+78.12% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.66% | 0.31% | #24 | $49.6M | 622,716 | $23.6M | 625,048 | -2,332-0.37% | Reduce |
| UBS Group AG |
| 0.01% | <0.01% | #169 | $48.4M | 606,558 | $7.8M | 207,237 | +399,321+192.69% | Add |
| FMR LLC |
| <0.01% | <0.01% | #240 | $47.5M | 595,629 | $22.0M | 582,200 | +13,429+2.31% | Add |
| AMERICAN CENTURY COMPANIES INC |
| 0.02% | — | #109 | $43.2M | 542,131 | $0 | 0 | +542,131 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | <0.01% | #150 | $40.2M | 503,774 | $17.8M | 472,273 | +31,501+6.67% | Add |
| Eversept Partners, LP |
| 1.77% | 1.35% | #15 | $34.2M | 428,652 | $25.6M | 677,392 | -248,740-36.72% | Reduce |
| OBERWEIS ASSET MANAGEMENT INC/ |
| 0.67% | 0.41% | #23 | $32.4M | 406,400 | $14.0M | 372,100 | +34,300+9.22% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #229 | $32.3M | 405,090 | $18.2M | 481,446 | -76,356-15.86% | Reduce |
| Purewater Capital LLC |
| 21.91% | 13.31% | #4 | $30.4M | 389,924 | $13.9M | 377,562 | +12,362+3.27% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #188 | $29.7M | 372,434 | $7.3M | 193,920 | +178,514+92.06% | Add |
| BARCLAYS PLC |
| 0.01% | <0.01% | #176 | $29.5M | 369,863 | $1.2M | 32,807 | +337,056+1,027.39% | Add |
| PRINCIPAL FINANCIAL GROUP INC |
| 0.01% | — | #127 | $27.4M | 343,444 | $0 | 0 | +343,444 | New Buy |
| Nuveen, LLC |
| 0.01% | <0.01% | #170 | $25.2M | 316,498 | $5.7M | 152,225 | +164,273+107.91% | Add |
| FIRST TRUST ADVISORS LP |
| 0.01% | 0.01% | #123 | $24.0M | 301,432 | $10.5M | 279,475 | +21,957+7.86% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.02% | 0.02% | #120 | $21.3M | 266,829 | $21.3M | 563,233 | -296,404-52.63% | Reduce |
| Seven Fleet Capital Management LP |
| 3.38% | 2.25% | #9 | $20.5M | 256,603 | $7.1M | 187,876 | +68,727+36.58% | Add |
| Jupiter Topco LLC |
| 0.01% | — | #152 | $20.0M | 250,937 | $0 | 0 | +250,937 | New Buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD |
| 0.05% | — | #85 | $19.2M | 241,376 | $0 | 0 | +241,376 | New Buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.07% | — | #74 | $19.2M | 240,752 | $0 | 0 | +240,752 | New Buy |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #212 | $19.1M | 239,557 | $0 | 0 | +239,557 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.03% | <0.01% | #96 | $18.5M | 232,353 | $305,694 | 8,100 | +224,253+2,768.56% | Add |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #187 | $18.0M | 225,868 | $6.1M | 162,456 | +63,412+39.03% | Add |
| Empowered Funds, LLC |
| 0.09% | 0.02% | #69 | $16.8M | 210,365 | $3.7M | 96,717 | +113,648+117.51% | Add |
| CITIGROUP INC |
| 0.01% | <0.01% | #179 | $16.5M | 206,891 | $7.3M | 194,750 | +12,141+6.23% | Add |
| ALGERT GLOBAL LLC |
| 0.18% | 0.12% | #50 | $15.3M | 191,841 | $7.7M | 204,060 | -12,219-5.99% | Reduce |
