| FMR LLC |
| 0.03% | 0.02% | #109 | $675.9M | 17.6M | $376.6M | 17.7M | -111,706-0.63% | Reduce |
| BlackRock, Inc. |
| 0.01% | <0.01% | #198 | $414.2M | 10.8M | $214.0M | 10.1M | +724,157+7.18% | Add |
| ARK Investment Management LLC |
| 2.48% | 1.93% | #4 | $383.5M | 10.0M | $248.8M | 11.7M | -1.7M-14.63% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #147 | $267.7M | 7.0M | $146.8M | 6.9M | +69,556+1.01% | Add |
| Quantinno Capital Management LP |
| 0.25% | 0.19% | #28 | $209.7M | 5.5M | $114.9M | 5.4M | +57,937+1.07% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #223 | $194.9M | 5.1M | $111.9M | 5.3M | -186,992-3.55% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | <0.01% | #129 | $174.0M | 4.5M | $3.5M | 163,215 | +4.4M+2,681.00% | Add |
| Sumitomo Mitsui Trust Group, Inc. |
| 0.09% | 0.07% | #62 | $160.8M | 4.2M | $108.5M | 5.1M | -915,587-17.92% | Reduce |
| Amova Asset Management Americas, Inc. |
| 2.08% | 1.53% | #8 | $160.7M | 4.2M | $108.3M | 5.1M | -911,661-17.86% | Reduce |
| MORGAN STANLEY |
| 0.01% | <0.01% | #189 | $128.5M | 3.4M | $32.9M | 2.8M | +534,669+18.98% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #154 | $120.7M | 3.1M | $87.2M | 4.1M | -960,241-23.37% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #196 | $118.2M | 3.1M | $61.7M | 2.9M | +178,562+6.15% | Add |
| CITADEL ADVISORS LLC |
| 0.01% | <0.01% | #145 | $113.7M | 3.0M | $19.8M | 931,734 | +2.0M+218.36% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #238 | $107.4M | 2.8M | $55.0M | 2.6M | +212,642+8.21% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.02% | 0.01% | #136 | $85.3M | 2.2M | $43.4M | 2.0M | +182,334+8.93% | Add |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.28% | 0.2% | #26 | $77.4M | 2.0M | $48.5M | 2.3M | -263,541-11.54% | Reduce |
| AQR CAPITAL MANAGEMENT LLC |
| 0.03% | 0.02% | #112 | $74.7M | 2.0M | $53.7M | 2.5M | -511,792-20.16% | Reduce |
| Point72 Asset Management, L.P. |
| 0.08% | — | #67 | $71.0M | 1.9M | $0 | 0 | +1.9M | New Buy |
| Capital World Investors |
| 0.01% | <0.01% | #190 | $57.2M | 1.5M | $30.8M | 1.5M | +40,731+2.80% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.03% | 0.02% | #105 | $48.6M | 1.3M | $27.2M | 1.3M | -12,428-0.97% | Reduce |
| NORTHERN TRUST CORP |
| 0.01% | <0.01% | #210 | $43.9M | 1.1M | $22.2M | 1.0M | +96,022+9.16% | Add |
| Nuveen, LLC |
| 0.01% | <0.01% | #155 | $43.1M | 1.1M | $13.3M | 625,796 | +498,837+79.71% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | <0.01% | #204 | $41.7M | 1.1M | $23.9M | 1.1M | -39,906-3.54% | Reduce |
| Casdin Capital, LLC |
| 2.02% | 3.66% | #9 | $40.3M | 1.1M | $48.3M | 2.3M | -1.2M-53.85% | Reduce |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.07% | 0.05% | #71 | $37.9M | 988,320 | $19.9M | 938,408 | +49,912+5.32% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #252 | $37.2M | 970,774 | $20.5M | 964,579 | +6,195+0.64% | Add |
| Anomaly Capital Management, LP |
| 1.27% | — | #12 | $33.3M | 867,794 | $0 | 0 | +867,794 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #244 | $32.8M | 855,399 | $1.2M | 58,000 | +797,399+1,374.83% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | <0.01% | #186 | $32.0M | 835,223 | $16.5M | 778,906 | +56,317+7.23% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.04% | 0.03% | #90 | $30.8M | 802,039 | $21.4M | 1.0M | -206,700-20.49% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #282 | $28.2M | 753,045 | $15.6M | 785,505 | -32,460-4.13% | Reduce |
| Blue Water Life Science Advisors, LP |
| 15.5% | 18.56% | #1 | $24.6M | 642,000 | $23.1M | 1.1M | -448,000-41.10% | Reduce |
| Freshford Capital Management, LLC |
| 7.88% | 7.14% | #2 | $23.0M | 600,423 | $14.3M | 672,956 | -72,533-10.78% | Reduce |
| Russell Investments Group, Ltd. |
| 0.02% | 0.01% | #132 | $21.6M | 564,307 | $10.2M | 480,619 | +83,688+17.41% | Add |
| CLOUGH CAPITAL PARTNERS L P |
| 1.72% | — | #11 | $21.1M | 549,973 | $0 | 0 | +549,973 | New Buy |
| HSBC HOLDINGS PLC |
| 0.01% | <0.01% | #170 | $20.3M | 537,009 | $5.9M | 285,389 | +251,620+88.17% | Add |
| IEQ CAPITAL, LLC |
| 0.09% | 0.07% | #61 | $20.2M | 526,390 | $14.9M | 700,684 | -174,294-24.87% | Reduce |
| SAMLYN CAPITAL, LLC |
| 0.31% | — | #22 | $19.3M | 504,048 | $0 | 0 | +504,048 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #251 | $19.0M | 494,868 | $10.5M | 494,762 | +106+0.02% | Add |
| Sands Capital Alternatives, LLC |
| 3.01% | 2.43% | #3 | $18.5M | 481,770 | $10.2M | 481,770 | 00.00% | Unchanged |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC |
| 0.02% | 0.01% | #115 | $17.1M | 445,983 | $3.5M | 165,250 | +280,733+169.88% | Add |
| Meridiem Capital Partners LP |
| 0.73% | 0.72% | #15 | $16.2M | 422,219 | $11.1M | 523,998 | -101,779-19.42% | Reduce |
| FIRST TRUST ADVISORS LP |
| 0.01% | <0.01% | #162 | $15.9M | 414,894 | $270,873 | 12,759 | +402,135+3,151.78% | Add |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd |
| 0.99% | 0.87% | #13 | $15.5M | 404,351 | $11.5M | 542,757 | -138,406-25.50% | Reduce |
| Duquesne Family Office LLC |
| 0.3% | — | #24 | $15.5M | 403,100 | $0 | 0 | +403,100 | New Buy |
| LORD, ABBETT & CO. LLC |
| 0.04% | 0.02% | #88 | $15.3M | 397,868 | $7.0M | 329,318 | +68,550+20.82% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #299 | $14.9M | 388,512 | $6.7M | 317,643 | +70,869+22.31% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #300 | $14.9M | 387,921 | $9.9M | 468,580 | -80,659-17.21% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #256 | $13.9M | 363,633 | $7.4M | 347,562 | +16,071+4.62% | Add |
| AMERICAN CENTURY COMPANIES INC |
| 0.01% | <0.01% | #205 | $12.4M | 322,486 | $6.2M | 292,201 | +30,285+10.36% | Add |
