| FMR LLC |
| 0.05% | 0.03% | #76 | $1.16B | 13.0M | $594.2M | 11.8M | +1.2M+10.57% | Add |
| BlackRock, Inc. |
| 0.01% | <0.01% | #126 | $577.7M | 6.5M | $278.5M | 5.5M | +985,384+17.85% | Add |
| PERCEPTIVE ADVISORS LLC |
| 5.76% | 3.73% | #6 | $383.5M | 4.3M | $190.8M | 3.8M | +536,271+14.17% | Add |
| RTW INVESTMENTS, LP |
| 3.22% | 2.09% | #10 | $377.5M | 4.3M | $210.4M | 4.2M | +80,000+1.92% | Add |
| Paradigm Biocapital Advisors LP |
| 6.38% | 2.02% | #5 | $341.0M | 3.8M | $98.7M | 2.0M | +1.9M+96.23% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | <0.01% | #143 | $306.2M | 3.4M | $154.2M | 3.1M | +391,280+12.80% | Add |
| STATE STREET CORP |
| 0.01% | <0.01% | #132 | $271.4M | 3.1M | $131.5M | 2.6M | +450,385+17.28% | Add |
| Venrock Adviser, LLC |
| 8.04% | 6.94% | #2 | $265.0M | 3.0M | $185.9M | 3.7M | -700,000-18.99% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.03% | 0.01% | #89 | $262.9M | 3.0M | $80.6M | 1.6M | +1.4M+85.20% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 1.44% | 1.03% | #15 | $248.5M | 2.8M | $140.8M | 2.8M | +8,381+0.30% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #111 | $239.3M | 2.6M | $86.8M | 1.7M | +841,353+48.89% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | <0.01% | #122 | $206.9M | 2.3M | $29.5M | 585,130 | +1.7M+298.22% | Add |
| Capital World Investors |
| 0.02% | <0.01% | #90 | $205.6M | 2.3M | $33.6M | 666,564 | +1.6M+247.39% | Add |
| Jupiter Topco LLC |
| 0.08% | — | #65 | $195.9M | 2.2M | $0 | 0 | +2.2M | New Buy |
| TCG Crossover Management, LLC |
| 4.06% | 2.74% | #9 | $168.7M | 1.9M | $95.9M | 1.9M | 00.00% | Unchanged |
| TANG CAPITAL MANAGEMENT LLC |
| 7.63% | 4.85% | #3 | $168.0M | 1.9M | $95.4M | 1.9M | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| 0.01% | <0.01% | #120 | $157.8M | 1.8M | $61.9M | 1.2M | +549,761+44.77% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.21% | — | #42 | $152.9M | 1.7M | $0 | 0 | +1.7M | New Buy |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.02% | 0.02% | #91 | $140.4M | 1.6M | $92.0M | 1.8M | -243,306-13.33% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #114 | $131.2M | 1.5M | $13.6M | 269,938 | +1.2M+447.55% | Add |
| FRANKLIN RESOURCES INC |
| 0.03% | 0.01% | #88 | $130.8M | 1.5M | $44.5M | 882,833 | +590,110+66.84% | Add |
| Remedium Capital Partners, LLC |
| 28.78% | 26.13% | #1 | $130.0M | 1.5M | $73.5M | 1.5M | +7,938+0.55% | Add |
| Affinity Asset Advisors, LLC |
| 5.13% | 3.33% | #7 | $113.6M | 1.3M | $64.5M | 1.3M | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| 0.01% | <0.01% | #153 | $98.9M | 1.1M | $44.5M | 979,299 | +113,727+11.61% | Add |
| Holocene Advisors, LP |
| 0.2% | — | #44 | $90.1M | 1.0M | $0 | 0 | +1.0M | New Buy |
| MARSHALL WACE, LLP |
| 0.07% | 0.01% | #70 | $88.0M | 991,693 | $7.0M | 139,259 | +852,434+612.12% | Add |
| Polar Capital Holdings Plc |
| 0.21% | 0.14% | #43 | $87.7M | 988,009 | $40.0M | 792,847 | +195,162+24.62% | Add |
| Siren, L.L.C. |
| 1.74% | 1.14% | #13 | $86.0M | 968,598 | $41.3M | 818,598 | +150,000+18.32% | Add |
| Capital International Investors |
| 0.02% | 0.02% | #97 | $84.8M | 955,196 | $88.1M | 1.7M | -790,933-45.30% | Reduce |
| BRAIDWELL LP |
| 2.89% | 1.57% | #12 | $78.1M | 879,467 | $47.1M | 932,823 | -53,356-5.72% | Reduce |
| Commodore Capital LP |
| 4.48% | 5.58% | #8 | $75.2M | 846,786 | $96.5M | 1.9M | -1.1M-55.72% | Reduce |
| UBS Group AG |
| 0.01% | 0.01% | #121 | $74.8M | 843,071 | $33.9M | 671,235 | +171,836+25.60% | Add |
| NORTHERN TRUST CORP |
| 0.01% | <0.01% | #138 | $59.9M | 674,529 | $29.2M | 578,907 | +95,622+16.52% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | <0.01% | #134 | $58.0M | 652,958 | $28.4M | 562,653 | +90,305+16.05% | Add |
| Pictet Asset Management Holding SA |
| 0.05% | 0.03% | #75 | $55.8M | 628,138 | $24.8M | 491,649 | +136,489+27.76% | Add |
| EMERALD ADVISERS, LLC |
| 1.19% | 0.98% | #19 | $50.4M | 567,430 | $30.9M | 613,365 | -45,935-7.49% | Reduce |
| VICTORY CAPITAL MANAGEMENT INC |
| 0.03% | 0.01% | #86 | $49.2M | 553,980 | $14.7M | 292,126 | +261,854+89.64% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #117 | $49.0M | 551,389 | $23.4M | 464,651 | +86,738+18.67% | Add |
| Candriam S.C.A. |
| 0.22% | 0.07% | #41 | $48.5M | 546,312 | $13.9M | 425,534 | +120,778+28.38% | Add |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.01% | <0.01% | #129 | $46.3M | 522,071 | $10.5M | 207,314 | +314,757+151.83% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #178 | $44.4M | 499,963 | $5.6M | 334,722 | +165,241+49.37% | Add |
| VOYA INVESTMENT MANAGEMENT LLC |
| 0.03% | <0.01% | #82 | $38.3M | 431,694 | $2.7M | 53,970 | +377,724+699.88% | Add |
| EMERALD MUTUAL FUND ADVISERS TRUST |
| 1.25% | 1% | #18 | $35.6M | 401,271 | $20.6M | 408,113 | -6,842-1.68% | Reduce |
| SAMLYN CAPITAL, LLC |
| 0.58% | 0.34% | #27 | $35.5M | 400,075 | $20.0M | 396,661 | +3,414+0.86% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #174 | $34.2M | 384,911 | $6.5M | 128,462 | +256,449+199.63% | Add |
| AMERIPRISE FINANCIAL INC |
| 0.01% | <0.01% | #146 | $31.6M | 356,082 | $8.0M | 159,217 | +196,865+123.65% | Add |
| Integral Health Asset Management, LLC |
| 1.14% | — | #21 | $28.9M | 325,000 | $0 | 0 | +325,000 | New Buy |
| Woodline Partners LP |
| 0.08% | 0.05% | #62 | $27.2M | 306,049 | $13.4M | 265,892 | +40,157+15.10% | Add |
| JENNISON ASSOCIATES LLC |
| 0.02% | — | #101 | $26.9M | 303,180 | $0 | 0 | +303,180 | New Buy |
| ADAR1 Capital Management, LLC |
| 1.16% | 1% | #20 | $25.2M | 283,982 | $17.1M | 338,323 | -54,341-16.06% | Reduce |
