| BlackRock, Inc. |
| 0.01% | <0.01% | #169 | $528.4M | 11.2M | $160.3M | 8.5M | +2.8M+32.46% | Add |
| Avoro Capital Advisors LLC |
| 3.04% | 0.93% | #10 | $338.2M | 7.2M | $94.5M | 5.0M | +2.2M+43.78% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 1.87% | 0.82% | #16 | $322.0M | 6.8M | $111.7M | 5.9M | +933,387+15.79% | Add |
| Jupiter Topco LLC |
| 0.11% | — | #72 | $264.0M | 5.6M | $0 | 0 | +5.6M | New Buy |
| Capital World Investors |
| 0.03% | — | #117 | $252.5M | 5.4M | $0 | 0 | +5.4M | New Buy |
| FMR LLC |
| 0.01% | <0.01% | #161 | $223.6M | 4.8M | $34.2M | 1.8M | +2.9M+162.65% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | <0.01% | #132 | $218.8M | 4.7M | $1.3M | 70,001 | +4.6M+6,545.67% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #162 | $171.5M | 3.6M | $47.2M | 2.5M | +1.1M+46.06% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #206 | $144.2M | 3.1M | $46.7M | 2.5M | +593,517+24.01% | Add |
| Capital International Investors |
| 0.03% | — | #119 | $139.4M | 3.0M | $0 | 0 | +3.0M | New Buy |
| Octagon Capital Advisors LP |
| 12.47% | 5.1% | #2 | $138.8M | 3.0M | $46.1M | 2.4M | +510,000+20.90% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.02% | <0.01% | #130 | $138.8M | 2.9M | $24.7M | 1.3M | +1.6M+126.08% | Add |
| Deep Track Capital, LP |
| 1.88% | 0.93% | #15 | $129.4M | 2.8M | $56.7M | 3.0M | -250,000-8.33% | Reduce |
| CITADEL ADVISORS LLC |
| 0.01% | <0.01% | #154 | $106.4M | 2.3M | $28.1M | 1.5M | +771,845+51.83% | Add |
| Commodore Capital LP |
| 5.6% | 2.19% | #4 | $94.1M | 2.0M | $37.8M | 2.0M | 00.00% | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.01% | <0.01% | #178 | $89.3M | 1.9M | $21.5M | 1.1M | +760,698+66.87% | Add |
| ALLIANCEBERNSTEIN L.P. |
| 0.03% | <0.01% | #120 | $84.8M | 1.8M | $1.7M | 91,703 | +1.7M+1,866.44% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #171 | $84.7M | 1.8M | $31.7M | 1.7M | +125,441+7.49% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #217 | $77.5M | 1.6M | $16.5M | 872,665 | +775,761+88.90% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.61% | — | #33 | $70.6M | 1.5M | $0 | 0 | +1.5M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #250 | $69.9M | 1.5M | $20.7M | 1.1M | +389,476+35.50% | Add |
| Siren, L.L.C. |
| 1.35% | 0.48% | #19 | $66.8M | 1.4M | $17.4M | 919,493 | +500,000+54.38% | Add |
| MARSHALL WACE, LLP |
| 0.05% | 0.02% | #104 | $61.1M | 1.3M | $22.7M | 1.2M | +98,121+8.17% | Add |
| NORTHERN TRUST CORP |
| 0.01% | <0.01% | #185 | $55.0M | 1.2M | $15.1M | 798,987 | +370,251+46.34% | Add |
| AMERIPRISE FINANCIAL INC |
| 0.01% | <0.01% | #158 | $54.0M | 1.1M | $18.3M | 966,608 | +181,755+18.80% | Add |
| Nuveen, LLC |
| 0.01% | <0.01% | #152 | $52.0M | 1.1M | $13.2M | 698,130 | +407,184+58.32% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | <0.01% | #180 | $51.0M | 1.1M | $15.3M | 808,715 | +274,861+33.99% | Add |
| Woodline Partners LP |
| 0.15% | 0.05% | #67 | $47.2M | 1.0M | $14.2M | 752,792 | +250,849+33.32% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.07% | 0.03% | #89 | $47.0M | 1.0M | $21.7M | 1.2M | -150,000-13.04% | Reduce |
| Boxer Capital Management, LLC |
| 3.54% | 1.49% | #8 | $47.0M | 998,500 | $11.3M | 598,500 | +400,000+66.83% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.03% | 0.02% | #115 | $43.4M | 921,818 | $22.7M | 1.2M | -279,792-23.28% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.05% | 0.03% | #97 | $42.2M | 897,658 | $24.1M | 1.3M | -376,563-29.55% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | <0.01% | #164 | $38.9M | 827,693 | $10.9M | 575,937 | +251,756+43.71% | Add |
| Holocene Advisors, LP |
| 0.08% | 0.05% | #82 | $37.5M | 796,574 | $20.6M | 1.1M | -295,393-27.05% | Reduce |
| AWM Investment Company, Inc. |
| 3.2% | 2.25% | #9 | $36.9M | 784,800 | $20.4M | 1.1M | -292,093-27.12% | Reduce |
| Bank of New York Mellon Corp |
| 0.01% | <0.01% | #192 | $36.6M | 777,271 | $14.2M | 752,922 | +24,349+3.23% | Add |
| Polar Capital Holdings Plc |
| 0.09% | — | #81 | $36.6M | 777,253 | $0 | 0 | +777,253 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #224 | $35.4M | 751,600 | $6.6M | 347,441 | +404,159+116.32% | Add |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.45% | 0.21% | #39 | $33.4M | 710,000 | $13.0M | 686,162 | +23,838+3.47% | Add |
| Neuberger Berman Group LLC |
| 0.02% | <0.01% | #133 | $32.3M | 687,539 | $2.5M | 133,369 | +554,170+415.52% | Add |
| Qube Research & Technologies Ltd |
| 0.03% | 0.01% | #116 | $32.1M | 682,901 | $8.1M | 426,055 | +256,846+60.28% | Add |
| Candriam S.C.A. |
| 0.13% | 0.07% | #70 | $28.9M | 614,425 | $13.0M | 971,218 | -356,793-36.74% | Reduce |
| ArrowMark Colorado Holdings LLC |
| 1.1% | 0.8% | #23 | $26.5M | 564,069 | $30.1M | 1.6M | -1.0M-64.63% | Reduce |
| Catalio Capital Management, LP |
| 4.97% | 4.1% | #6 | $26.5M | 562,672 | $19.6M | 1.0M | -475,312-45.79% | Reduce |
| Blackstone Inc. |
| 0.08% | 0.04% | #84 | $26.4M | 561,612 | $9.6M | 508,668 | +52,944+10.41% | Add |
| Integral Health Asset Management, LLC |
| 1.02% | 0.36% | #24 | $25.9M | 550,000 | $7.6M | 400,000 | +150,000+37.50% | Add |
| BAMCO INC /NY/ |
| 0.04% | — | #109 | $24.5M | 520,108 | $0 | 0 | +520,108 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #222 | $23.5M | 499,467 | $9.3M | 493,977 | +5,490+1.11% | Add |
| FRANKLIN RESOURCES INC |
| <0.01% | — | #204 | $22.9M | 486,219 | $0 | 0 | +486,219 | New Buy |
| Point72 Asset Management, L.P. |
| 0.03% | <0.01% | #128 | $22.8M | 483,980 | $3.3M | 175,490 | +308,490+175.79% | Add |
