| BlackRock, Inc. |
| 0.01% | 0.01% | #127 | $355.1M | 3.0M | $323.6M | 2.7M | +244,162+8.91% | Add |
| RTW INVESTMENTS, LP |
| 2.22% | 1.96% | #3 | $259.6M | 2.2M | $196.9M | 1.7M | +514,131+30.81% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #97 | $227.7M | 1.9M | $212.0M | 1.8M | +117,604+6.55% | Add |
| Artisan Partners Limited Partnership |
| 0.31% | 0.27% | #22 | $197.5M | 1.7M | $171.2M | 1.5M | +209,400+14.43% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #148 | $174.0M | 1.5M | $170.6M | 1.4M | +17,501+1.21% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.06% | 0.08% | #59 | $167.3M | 1.4M | $197.2M | 1.7M | -264,060-15.81% | Reduce |
| FMR LLC |
| 0.01% | 0.01% | #120 | $141.8M | 1.2M | $160.7M | 1.4M | -169,937-12.48% | Reduce |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.02% | 0.03% | #77 | $112.4M | 944,517 | $123.6M | 1.0M | -102,935-9.83% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #123 | $104.9M | 881,899 | $96.5M | 817,110 | +64,789+7.93% | Add |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 1.4% | 1.48% | #9 | $104.7M | 880,338 | $89.8M | 760,825 | +119,513+15.71% | Add |
| BNP Paribas Asset Management Holding S.A. |
| 0.1% | — | #40 | $103.1M | 866,528 | $0 | 0 | +866,528 | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #157 | $101.9M | 856,517 | $93.0M | 788,302 | +68,215+8.65% | Add |
| Holocene Advisors, LP |
| 0.21% | 0.36% | #29 | $93.2M | 783,636 | $147.4M | 1.2M | -465,022-37.24% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | 0.01% | #130 | $90.9M | 766,216 | $81.6M | 714,896 | +51,320+7.18% | Add |
| Stephens Investment Management Group LLC |
| 0.88% | 0.91% | #12 | $82.5M | 693,437 | $66.3M | 561,530 | +131,907+23.49% | Add |
| FULLER & THALER ASSET MANAGEMENT, INC. |
| 0.22% | 0.27% | #28 | $81.5M | 685,496 | $79.6M | 674,698 | +10,798+1.60% | Add |
| BRAIDWELL LP |
| 2.88% | 2.4% | #2 | $77.8M | 654,262 | $72.0M | 610,192 | +44,070+7.22% | Add |
| D. E. Shaw & Co., Inc. |
| 0.04% | 0.04% | #66 | $76.1M | 639,586 | $66.6M | 564,366 | +75,220+13.33% | Add |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| 0.05% | 0.04% | #61 | $66.8M | 561,251 | $46.1M | 390,577 | +170,674+43.70% | Add |
| BLAIR WILLIAM & CO/IL |
| 0.16% | 0.21% | #32 | $62.4M | 524,690 | $74.2M | 628,385 | -103,695-16.50% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #150 | $55.4M | 465,719 | $51.0M | 432,539 | +33,180+7.67% | Add |
| Polar Capital Holdings Plc |
| 0.13% | 0.18% | #38 | $54.5M | 458,089 | $49.8M | 421,612 | +36,477+8.65% | Add |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.02% | 0.04% | #74 | $53.6M | 450,865 | $68.8M | 582,879 | -132,014-22.65% | Reduce |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
| 0.04% | 0.02% | #65 | $53.1M | 448,259 | $28.3M | 247,746 | +200,513+80.93% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #147 | $43.1M | 362,346 | $41.1M | 348,563 | +13,783+3.95% | Add |
| LOOMIS SAYLES & CO L P |
| 0.05% | 0.06% | #60 | $41.4M | 347,959 | $43.4M | 367,894 | -19,935-5.42% | Reduce |
| Capital Research Global Investors |
| 0.01% | 0.01% | #124 | $39.9M | 335,209 | $60.1M | 509,590 | -174,381-34.22% | Reduce |
| Allspring Global Investments Holdings, LLC |
| 0.06% | 0.09% | #57 | $37.4M | 300,057 | $55.2M | 467,113 | -167,056-35.76% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #143 | $36.6M | 307,995 | $33.6M | 285,086 | +22,909+8.04% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #159 | $36.0M | 302,762 | $15.5M | 131,264 | +171,498+130.65% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | 0.01% | #133 | $35.5M | 298,301 | $33.3M | 281,897 | +16,404+5.82% | Add |
| AMERIPRISE FINANCIAL INC |
| 0.01% | 0.01% | #111 | $34.8M | 292,513 | $27.9M | 236,786 | +55,727+23.53% | Add |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.11% | — | #39 | $34.4M | 288,924 | $0 | 0 | +288,924 | New Buy |
| Point72 Asset Management, L.P. |
| 0.04% | 0.09% | #67 | $32.5M | 273,162 | $73.3M | 621,105 | -347,943-56.02% | Reduce |
| Qube Research & Technologies Ltd |
| 0.03% | 0.03% | #73 | $32.3M | 271,624 | $26.8M | 226,884 | +44,740+19.72% | Add |
| Rock Springs Capital Management LP |
| 1.57% | 1.82% | #8 | $32.1M | 269,650 | $30.9M | 261,750 | +7,900+3.02% | Add |
| CITIGROUP INC |
| 0.01% | 0.01% | #98 | $29.7M | 249,404 | $27.4M | 232,123 | +17,281+7.44% | Add |
| DEUTSCHE BANK AG\ |
| 0.01% | 0.01% | #108 | $28.3M | 238,193 | $25.5M | 215,758 | +22,435+10.40% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #119 | $28.1M | 235,963 | $26.4M | 223,699 | +12,264+5.48% | Add |
| PERCEPTIVE ADVISORS LLC |
| 0.4% | 0.24% | #19 | $26.6M | 223,766 | $12.4M | 105,026 | +118,740+113.06% | Add |
| FRED ALGER MANAGEMENT, LLC |
| 0.09% | 0.15% | #42 | $26.3M | 220,789 | $33.1M | 280,040 | -59,251-21.16% | Reduce |
| OBERWEIS ASSET MANAGEMENT INC/ |
| 0.5% | 0.54% | #17 | $24.0M | 202,004 | $18.4M | 156,004 | +46,000+29.49% | Add |
| Ophir Asset Management Pty Ltd |
| 1.97% | 4.62% | #5 | $24.0M | 201,491 | $39.6M | 335,807 | -134,316-40.00% | Reduce |
| BARCLAYS PLC |
| <0.01% | 0.01% | #139 | $22.8M | 191,798 | $22.2M | 188,345 | +3,453+1.83% | Add |
| NEXT CENTURY GROWTH INVESTORS LLC |
| 1.18% | 1.47% | #11 | $22.3M | 187,064 | $20.0M | 169,306 | +17,758+10.49% | Add |
| BAMCO INC /NY/ |
| 0.03% | 0.07% | #71 | $21.6M | 181,430 | $21.7M | 183,900 | -2,470-1.34% | Reduce |
| SEI INVESTMENTS CO |
| 0.02% | 0.02% | #80 | $21.3M | 178,765 | $23.5M | 198,904 | -20,139-10.12% | Reduce |
| First Light Asset Management, LLC |
| 1.21% | 1.78% | #10 | $19.9M | 167,092 | $19.8M | 168,116 | -1,024-0.61% | Reduce |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | 0.01% | #113 | $19.7M | 165,998 | $19.7M | 166,637 | -639-0.38% | Reduce |
| Prosight Management, LP |
| 3.39% | 0.19% | #1 | $19.7M | 165,500 | $1.2M | 10,000 | +155,500+1,555.00% | Add |
