| ARK Investment Management LLC |
| 3.34% | 4.19% | #6 | $516.0M | 9.5M | $538.2M | 11.3M | -1.9M-16.38% | Reduce |
| BlackRock, Inc. |
| 0.01% | 0.01% | #198 | $455.4M | 8.3M | $365.3M | 7.7M | +668,904+8.71% | Add |
| Orbis Allan Gray Ltd |
| 1.02% | 1.23% | #12 | $297.2M | 5.4M | $290.5M | 6.1M | -656,850-10.76% | Reduce |
| Capital World Investors |
| 0.03% | 0.03% | #110 | $259.0M | 4.7M | $224.8M | 4.7M | +24,488+0.52% | Add |
| STATE STREET CORP |
| 0.01% | 0.01% | #194 | $235.7M | 4.3M | $189.4M | 4.0M | +339,166+8.52% | Add |
| GSK plc |
| 29.17% | 25.57% | #1 | $175.7M | 3.2M | $153.2M | 3.2M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #193 | $136.9M | 2.5M | $113.1M | 2.4M | +132,751+5.58% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.07% | 0.1% | #74 | $112.0M | 2.1M | $140.5M | 3.0M | -899,578-30.47% | Reduce |
| SR ONE CAPITAL MANAGEMENT, LP |
| 10.7% | 10.59% | #2 | $111.2M | 2.0M | $97.0M | 2.0M | 00.00% | Unchanged |
| TWO SIGMA INVESTMENTS, LP |
| 0.08% | 0.06% | #70 | $108.5M | 2.0M | $70.5M | 1.5M | +505,570+34.09% | Add |
| FMR LLC |
| <0.01% | <0.01% | #243 | $104.1M | 1.9M | $93.0M | 2.0M | -46,191-2.36% | Reduce |
| Sumitomo Mitsui Trust Group, Inc. |
| 0.05% | 0.06% | #84 | $93.8M | 1.7M | $88.2M | 1.9M | -133,141-7.18% | Reduce |
| Amova Asset Management Americas, Inc. |
| 1.21% | 1.25% | #11 | $93.8M | 1.7M | $88.2M | 1.9M | -133,778-7.22% | Reduce |
| EcoR1 Capital, LLC |
| 3.68% | 2.8% | #4 | $75.8M | 1.4M | $66.1M | 1.4M | 00.00% | Unchanged |
| UBS Group AG |
| 0.01% | 0.01% | #175 | $72.0M | 1.3M | $83.8M | 1.8M | -442,531-25.11% | Reduce |
| Capital International Investors |
| 0.01% | 0.01% | #139 | $69.2M | 1.3M | $56.5M | 1.2M | +81,613+6.88% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #356 | $64.5M | 1.2M | $54.4M | 1.1M | +39,304+3.44% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #255 | $63.0M | 1.2M | $46.8M | 983,072 | +172,033+17.50% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | 0.01% | #240 | $59.5M | 1.1M | $78.4M | 1.6M | -555,828-33.75% | Reduce |
| NEA Management Company, LLC |
| 3.64% | 2.86% | #5 | $57.7M | 1.1M | $50.4M | 1.1M | 00.00% | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #188 | $57.7M | 1.1M | $49.4M | 1.0M | +18,488+1.78% | Add |
| CITADEL ADVISORS LLC |
| 0.01% | 0.01% | #205 | $55.2M | 1.0M | $64.1M | 1.3M | -335,456-24.89% | Reduce |
| D. E. Shaw & Co., Inc. |
| 0.03% | <0.01% | #115 | $55.0M | 1.0M | $6.8M | 142,700 | +865,412+606.46% | Add |
| MORGAN STANLEY |
| <0.01% | 0.01% | #295 | $48.0M | 879,949 | $90.6M | 1.4M | -517,910-37.05% | Reduce |
| NORTHERN TRUST CORP |
| 0.01% | 0.01% | #220 | $47.1M | 863,091 | $38.2M | 802,181 | +60,910+7.59% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #342 | $35.4M | 648,713 | $26.0M | 546,826 | +101,887+18.63% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #196 | $31.1M | 570,040 | $25.8M | 542,682 | +27,358+5.04% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #357 | $24.6M | 431,669 | $20.3M | 457,639 | -25,970-5.67% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #185 | $24.0M | 439,732 | $17.9M | 377,178 | +62,554+16.58% | Add |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd |
| 1.33% | 1.45% | #10 | $20.8M | 381,991 | $19.1M | 400,877 | -18,886-4.71% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | 0.01% | #346 | $18.6M | 341,480 | $39.4M | 828,100 | -486,620-58.76% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #283 | $17.8M | 326,761 | $14.8M | 311,383 | +15,378+4.94% | Add |
| PEAK6 LLC |
| 0.03% | 0.05% | #105 | $16.7M | 305,916 | $22.6M | 475,704 | -169,788-35.69% | Reduce |
| Logos Global Management LP |
| 0.7% | — | #16 | $16.4M | 300,000 | $0 | 0 | +300,000 | New Buy |
| Squarepoint Ops LLC |
| 0.02% | 0.01% | #135 | $15.9M | 290,989 | $8.3M | 173,675 | +117,314+67.55% | Add |
| Jump Financial, LLC |
| 0.12% | 0.07% | #52 | $15.2M | 277,952 | $5.1M | 107,439 | +170,513+158.71% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #290 | $15.0M | 275,375 | $23.5M | 494,218 | -218,843-44.28% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #366 | $14.9M | 272,372 | $19.7M | 414,220 | -141,848-34.24% | Reduce |
| NORGES BANK |
| <0.01% | <0.01% | #348 | $14.8M | 270,756 | $15.5M | 456,060 | -185,304-40.63% | Reduce |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #302 | $14.4M | 263,169 | $13.4M | 280,709 | -17,540-6.25% | Reduce |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #289 | $13.7M | 250,614 | $13.6M | 286,839 | -36,225-12.63% | Reduce |
| Vestmark Advisory Solutions, Inc. |
| 0.12% | 0.14% | #51 | $13.2M | 242,266 | $12.2M | 256,779 | -14,513-5.65% | Reduce |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #268 | $12.7M | 231,988 | $10.5M | 220,274 | +11,714+5.32% | Add |
| CITIGROUP INC |
| <0.01% | <0.01% | #259 | $11.8M | 216,316 | $4.8M | 100,970 | +115,346+114.24% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #291 | $11.1M | 203,089 | $9.1M | 190,766 | +12,323+6.46% | Add |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #353 | $9.4M | 173,045 | $7.8M | 163,719 | +9,326+5.70% | Add |
| Marex Group plc |
| 0.04% | 0.04% | #99 | $9.3M | 170,584 | $6.4M | 134,097 | +36,487+27.21% | Add |
| Swiss National Bank |
| <0.01% | <0.01% | #237 | $9.2M | 169,200 | $8.1M | 169,700 | -500-0.29% | Reduce |
| Susquehanna Portfolio Strategies, LLC |
| 0.14% | 0.07% | #44 | $8.9M | 164,026 | $5.0M | 105,373 | +58,653+55.66% | Add |
| Legal & General Group Plc |
| <0.01% | <0.01% | #324 | $8.9M | 163,810 | $3.6M | 75,640 | +88,170+116.57% | Add |
