| BAKER BROS. ADVISORS LP |
| 5.44% | 5.48% | #2 | $1.09B | 42.9M | $954.9M | 42.9M | +16,214+0.04% | Add |
| BlackRock, Inc. |
| 0.01% | 0.01% | #111 | $569.6M | 22.5M | $479.7M | 21.6M | +964,252+4.47% | Add |
| STATE STREET CORP |
| 0.01% | 0.01% | #121 | $229.6M | 9.1M | $185.5M | 8.3M | +743,441+8.92% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #98 | $223.6M | 8.8M | $193.0M | 8.7M | +166,805+1.92% | Add |
| RTW INVESTMENTS, LP |
| 1.54% | 1.58% | #6 | $180.8M | 7.1M | $159.0M | 7.1M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #174 | $145.8M | 5.8M | $126.0M | 5.7M | +102,350+1.81% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.02% | 0.01% | #84 | $93.5M | 3.7M | $70.2M | 3.2M | +539,828+17.11% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #151 | $85.0M | 3.4M | $77.1M | 3.5M | -106,560-3.08% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #134 | $65.3M | 2.6M | $34.7M | 1.6M | +1.0M+65.63% | Add |
| Point72 Asset Management, L.P. |
| 0.07% | 0.07% | #39 | $62.3M | 2.5M | $58.0M | 2.6M | -143,748-5.52% | Reduce |
| Qube Research & Technologies Ltd |
| 0.06% | 0.02% | #44 | $61.9M | 2.4M | $21.2M | 950,299 | +1.5M+157.46% | Add |
| CITADEL ADVISORS LLC |
| 0.01% | <0.01% | #123 | $57.8M | 2.3M | $14.7M | 658,660 | +1.6M+246.64% | Add |
| Pictet Asset Management Holding SA |
| 0.05% | 0.05% | #52 | $50.1M | 2.0M | $44.7M | 2.0M | -42,846-2.11% | Reduce |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.02% | 0.02% | #71 | $49.8M | 2.0M | $34.9M | 1.6M | +399,954+25.48% | Add |
| MARSHALL WACE, LLP |
| 0.04% | <0.01% | #61 | $44.7M | 1.8M | $1.7M | 76,187 | +1.7M+2,216.46% | Add |
| D. E. Shaw & Co., Inc. |
| 0.02% | 0.01% | #73 | $43.0M | 1.7M | $16.2M | 729,836 | +968,101+132.65% | Add |
| BRAIDWELL LP |
| 1.54% | 1.84% | #7 | $41.7M | 1.6M | $55.0M | 2.5M | -824,800-33.38% | Reduce |
| NORGES BANK |
| <0.01% | <0.01% | #155 | $41.1M | 1.6M | $23.6M | 1.4M | +202,697+14.27% | Add |
| Frazier Life Sciences Management, L.P. |
| 0.79% | 0.82% | #9 | $36.4M | 1.4M | $32.0M | 1.4M | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #158 | $34.6M | 1.4M | $28.3M | 1.3M | +94,811+7.45% | Add |
| Nuveen, LLC |
| 0.01% | 0.01% | #113 | $34.1M | 1.3M | $23.1M | 1.0M | +311,205+30.01% | Add |
| Artisan Partners Limited Partnership |
| 0.05% | 0.05% | #50 | $33.5M | 1.3M | $29.6M | 1.3M | -6,679-0.50% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #192 | $32.9M | 1.3M | $34.6M | 1.6M | -253,385-16.31% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.04% | 0.06% | #54 | $32.4M | 1.3M | $38.4M | 1.7M | -441,600-25.61% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #156 | $30.5M | 1.2M | $26.1M | 1.2M | +32,776+2.79% | Add |
| Allspring Global Investments Holdings, LLC |
| 0.04% | 0.04% | #55 | $28.5M | 1.1M | $21.3M | 954,855 | +177,711+18.61% | Add |
| Rockefeller Capital Management L.P. |
| 0.04% | 0.04% | #60 | $25.7M | 1.0M | $22.9M | 1.0M | -11,937-1.16% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #219 | $23.9M | 946,639 | $25.4M | 1.2M | -241,767-20.34% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| 0.02% | 0.01% | #83 | $23.5M | 926,992 | $17.3M | 775,121 | +151,871+19.59% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | <0.01% | #141 | $23.1M | 912,370 | $19.5M | 875,720 | +36,650+4.19% | Add |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | 0.01% | #120 | $21.6M | 855,435 | $22.7M | 1.0M | -164,389-16.12% | Reduce |
| Invesco Ltd. |
| <0.01% | <0.01% | #209 | $20.5M | 810,462 | $18.6M | 836,510 | -26,048-3.11% | Reduce |
| PRINCIPAL FINANCIAL GROUP INC |
| 0.01% | 0.01% | #102 | $20.0M | 789,196 | $17.1M | 768,224 | +20,972+2.73% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #172 | $19.2M | 760,629 | $16.4M | 736,558 | +24,071+3.27% | Add |
| PANAGORA ASSET MANAGEMENT INC |
| 0.06% | 0.06% | #47 | $18.0M | 710,906 | $15.3M | 688,649 | +22,257+3.23% | Add |
| Fisher Asset Management, LLC |
| 0.01% | 0.01% | #138 | $17.7M | 699,230 | $16.3M | 732,872 | -33,642-4.59% | Reduce |
| FRED ALGER MANAGEMENT, LLC |
| 0.05% | 0.12% | #48 | $16.4M | 648,611 | $28.4M | 1.3M | -628,540-49.21% | Reduce |
| Allianz Asset Management GmbH |
| 0.01% | 0.02% | #87 | $15.7M | 706,664 | $15.7M | 706,664 | 00.00% | Unchanged |
| RICE HALL JAMES & ASSOCIATES, LLC |
| 0.76% | 0.77% | #10 | $15.7M | 618,887 | $13.7M | 617,489 | +1,398+0.23% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #175 | $15.3M | 606,536 | $13.9M | 624,260 | -17,724-2.84% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #143 | $14.9M | 589,924 | $15.7M | 705,461 | -115,537-16.38% | Reduce |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| 0.01% | 0.01% | #92 | $14.8M | 583,852 | $12.7M | 571,776 | +12,076+2.11% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | 0.01% | #148 | $13.2M | 522,749 | $11.8M | 527,913 | -5,164-0.98% | Reduce |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | <0.01% | #81 | $12.9M | 510,000 | $222,600 | 10,000 | +500,000+5,000.00% | Add |
| GLENMEDE TRUST CO NA |
| 0.05% | 0.04% | #49 | $12.4M | 488,546 | $9.0M | 405,892 | +82,654+20.36% | Add |
| Hudson Bay Capital Management LP |
| 0.03% | 0.03% | #63 | $11.8M | 465,000 | $9.9M | 445,506 | +19,494+4.38% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #213 | $11.6M | 460,053 | $10.0M | 448,549 | +11,504+2.56% | Add |
| JUPITER ASSET MANAGEMENT LTD |
| 0.06% | 0.06% | #43 | $11.6M | 458,466 | $10.9M | 491,093 | -32,627-6.64% | Reduce |
| PUBLIC SECTOR PENSION INVESTMENT BOARD |
| 0.03% | 0.03% | #65 | $11.0M | 435,375 | $10.0M | 447,930 | -12,555-2.80% | Reduce |
| MACKENZIE FINANCIAL CORP |
| 0.01% | <0.01% | #96 | $10.6M | 420,825 | $2.3M | 101,337 | +319,488+315.27% | Add |
