| BAKER BROS. ADVISORS LP |
| 12.57% | 15% | #1 | $2.51B | 8.8M | $2.61B | 8.8M | +2,514+0.03% | Add |
| PRIMECAP MANAGEMENT CO/CA/ |
| 0.84% | 1.16% | #9 | $1.43B | 5.0M | $1.48B | 5.0M | +32,750+0.66% | Add |
| Capital International Investors |
| 0.25% | 0.29% | #25 | $1.20B | 4.2M | $1.23B | 4.2M | +51,495+1.24% | Add |
| FMR LLC |
| 0.03% | 0.06% | #76 | $706.3M | 2.5M | $1.10B | 3.7M | -1.2M-32.90% | Reduce |
| Capital World Investors |
| 0.08% | 0.07% | #46 | $641.1M | 2.2M | $481.9M | 1.6M | +626,895+38.63% | Add |
| CITADEL ADVISORS LLC |
| 0.05% | 0.05% | #61 | $412.0M | 1.4M | $312.6M | 1.1M | +393,319+37.37% | Add |
| Temasek Holdings (Private) Ltd |
| 0.65% | 0.84% | #14 | $241.0M | 845,729 | $256.2M | 862,643 | -16,914-1.96% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.02% | #85 | $216.2M | 758,752 | $160.3M | 539,769 | +218,983+40.57% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #155 | $197.9M | 694,618 | $195.3M | 657,501 | +37,117+5.65% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.05% | 0.03% | #56 | $162.0M | 568,323 | $60.8M | 204,846 | +363,477+177.44% | Add |
| MORGAN STANLEY |
| 0.01% | 0.01% | #118 | $141.8M | 497,437 | $120.4M | 353,294 | +144,143+40.80% | Add |
| Siren, L.L.C. |
| 2.68% | 3.83% | #5 | $132.5M | 465,000 | $138.1M | 465,000 | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.01% | #114 | $125.2M | 439,336 | $120.4M | 405,273 | +34,063+8.40% | Add |
| Baird Financial Group, Inc. |
| 0.14% | 0.16% | #32 | $105.1M | 368,978 | $103.8M | 349,651 | +19,327+5.53% | Add |
| Man Group plc |
| 0.14% | 0.13% | #33 | $87.6M | 307,463 | $71.8M | 241,922 | +65,541+27.09% | Add |
| Capital International, Inc./CA/ |
| 0.61% | 0.69% | #16 | $87.1M | 305,477 | $89.8M | 302,243 | +3,234+1.07% | Add |
| Candriam S.C.A. |
| 0.37% | 0.3% | #19 | $82.5M | 289,735 | $59.9M | 197,261 | +92,474+46.88% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.06% | 0.01% | #53 | $81.7M | 286,552 | $10.0M | 33,543 | +253,009+754.28% | Add |
| UBS Group AG |
| 0.01% | 0.02% | #108 | $73.7M | 258,589 | $123.3M | 415,330 | -156,741-37.74% | Reduce |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.03% | 0.02% | #75 | $71.2M | 249,758 | $32.8M | 110,586 | +139,172+125.85% | Add |
| FIRST TRUST ADVISORS LP |
| 0.04% | 0.05% | #65 | $70.1M | 245,823 | $71.7M | 241,426 | +4,397+1.82% | Add |
| M&G Plc |
| 0.32% | 0.21% | #21 | $63.7M | 223,445 | $41.0M | 138,163 | +85,282+61.73% | Add |
| Nuveen, LLC |
| 0.01% | 0.02% | #98 | $57.3M | 201,062 | $58.3M | 196,429 | +4,633+2.36% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #153 | $54.6M | 188,405 | $22.0M | 77,538 | +110,867+142.98% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.03% | 0.03% | #79 | $52.9M | 185,544 | $54.7M | 184,356 | +1,188+0.64% | Add |
| MARSHALL WACE, LLP |
| 0.04% | 0.05% | #67 | $50.7M | 177,987 | $51.3M | 172,643 | +5,344+3.10% | Add |
| Capital International Sarl |
| 0.71% | 0.85% | #12 | $50.0M | 175,542 | $51.6M | 173,879 | +1,663+0.96% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #137 | $44.9M | 157,701 | $28.7M | 96,677 | +61,024+63.12% | Add |
| FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #116 | $37.6M | 132,031 | $59.9M | 201,641 | -69,610-34.52% | Reduce |
| Lansforsakringar Fondforvaltning AB (publ) |
| 0.16% | — | #30 | $35.2M | 123,352 | $0 | 0 | +123,352 | New Buy |
| Artisan Partners Limited Partnership |
| 0.05% | 0.07% | #58 | $32.9M | 115,374 | $40.7M | 137,216 | -21,842-15.92% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.04% | 0.03% | #68 | $29.1M | 101,980 | $19.4M | 65,456 | +36,524+55.80% | Add |
| JENNISON ASSOCIATES LLC |
| 0.02% | 0.03% | #89 | $28.7M | 100,698 | $45.9M | 154,465 | -53,767-34.81% | Reduce |
| LAZARD ASSET MANAGEMENT LLC |
| 0.04% | 0.03% | #70 | $25.7M | 90,348 | $18.7M | 62,917 | +27,431+43.60% | Add |
| Patient Square Capital LP |
| 3.97% | 4.24% | #2 | $25.7M | 90,020 | $23.9M | 80,542 | +9,478+11.77% | Add |
| Qube Research & Technologies Ltd |
| 0.02% | — | #84 | $23.2M | 81,279 | $0 | 0 | +81,279 | New Buy |
| Squarepoint Ops LLC |
| 0.02% | 0.03% | #81 | $22.4M | 78,561 | $22.0M | 74,124 | +4,437+5.99% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #176 | $22.2M | 78,061 | $35.5M | 119,608 | -41,547-34.74% | Reduce |
| CAPITAL INTERNATIONAL LTD /CA/ |
| 0.72% | 0.84% | #11 | $22.0M | 77,161 | $22.7M | 76,515 | +646+0.84% | Add |
| Life Cycle Investment Partners Ltd |
| 0.1% | — | #41 | $20.8M | 73,048 | $0 | 0 | +73,048 | New Buy |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #152 | $20.5M | 71,861 | $20.9M | 70,391 | +1,470+2.09% | Add |
| ABN AMRO INVESTMENT SOLUTIONS |
| 0.16% | 0.18% | #29 | $18.7M | 65,524 | $14.1M | 47,564 | +17,960+37.76% | Add |
| ENVESTNET ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #135 | $17.2M | 60,525 | $17.7M | 59,611 | +914+1.53% | Add |
| Legal & General Group Plc |
| <0.01% | <0.01% | #143 | $17.1M | 59,890 | $17.8M | 59,812 | +78+0.13% | Add |
| PANAGORA ASSET MANAGEMENT INC |
| 0.05% | 0.06% | #57 | $17.1M | 59,831 | $17.0M | 57,320 | +2,511+4.38% | Add |
| VAN ECK ASSOCIATES CORP |
| 0.01% | 0.02% | #106 | $15.7M | 55,002 | $32.2M | 108,305 | -53,303-49.22% | Reduce |
| Woodline Partners LP |
| 0.05% | — | #60 | $15.4M | 54,064 | $0 | 0 | +54,064 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #160 | $15.1M | 53,086 | $15.5M | 52,063 | +1,023+1.96% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #194 | $13.9M | 48,942 | $32.5M | 109,553 | -60,611-55.33% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #161 | $13.3M | 46,733 | $16.9M | 56,879 | -10,146-17.84% | Reduce |
