| BlackRock, Inc. |
| 0.01% | <0.01% | #148 | $355.7M | 10.7M | $152.9M | 7.3M | +3.4M+45.96% | Add |
| RTW INVESTMENTS, LP |
| 2.22% | 0.76% | #10 | $260.3M | 7.8M | $76.4M | 3.6M | +4.1M+113.68% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #120 | $226.7M | 6.8M | $112.8M | 5.4M | +1.4M+26.07% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| 0.07% | 0.04% | #58 | $214.1M | 6.6M | $95.9M | 4.6M | +2.0M+43.31% | Add |
| STATE STREET CORP |
| 0.01% | <0.01% | #138 | $205.6M | 6.2M | $105.2M | 5.0M | +1.1M+22.65% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #181 | $143.5M | 4.3M | $87.8M | 4.2M | +106,660+2.55% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.09% | 0.04% | #54 | $120.9M | 3.6M | $46.2M | 2.2M | +1.4M+64.17% | Add |
| SANDS CAPITAL MANAGEMENT, LLC |
| 0.39% | 0.26% | #29 | $105.5M | 3.2M | $67.3M | 3.2M | -56,165-1.75% | Reduce |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.35% | 0.13% | #32 | $98.2M | 2.9M | $30.0M | 1.4M | +1.5M+105.42% | Add |
| FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.89% | 0.47% | #19 | $95.1M | 2.8M | $45.9M | 2.2M | +656,754+29.97% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #153 | $86.1M | 2.6M | $38.8M | 1.8M | +729,437+39.44% | Add |
| Sofinnova Investments, Inc. |
| 3.83% | 2.78% | #4 | $74.0M | 2.2M | $73.2M | 3.5M | -1.3M-36.57% | Reduce |
| Bellevue Group AG |
| 1.39% | 1.19% | #15 | $66.2M | 2.0M | $49.9M | 2.4M | -397,225-16.69% | Reduce |
| D. E. Shaw & Co., Inc. |
| 0.03% | 0.02% | #83 | $57.8M | 1.7M | $26.4M | 1.3M | +469,175+37.21% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.07% | 0.02% | #59 | $52.8M | 1.6M | $10.1M | 480,000 | +1.1M+229.17% | Add |
| GW&K Investment Management, LLC |
| 0.39% | 0.3% | #30 | $49.5M | 1.5M | $33.8M | 1.6M | -134,248-8.31% | Reduce |
| MPM BioImpact LLC |
| 2.89% | — | #8 | $47.4M | 1.4M | $0 | 0 | +1.4M | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #154 | $45.3M | 1.4M | $16.8M | 804,109 | +552,392+68.70% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #197 | $44.2M | 1.3M | $27.4M | 910,183 | +414,622+45.55% | Add |
| Caption Management, LLC |
| 0.2% | 0.09% | #41 | $42.1M | 1.3M | $15.5M | 740,000 | +520,700+70.36% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | 0.01% | #132 | $41.8M | 1.3M | $55.3M | 2.6M | -1.4M-52.65% | Reduce |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
| 0.18% | 0.12% | #42 | $41.5M | 1.2M | $29.9M | 1.4M | -185,278-12.99% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #194 | $38.3M | 1.1M | $21.9M | 1.0M | +101,908+9.74% | Add |
| Candriam S.C.A. |
| 0.15% | 0.09% | #45 | $33.4M | 1.0M | $18.4M | 799,384 | +202,457+25.33% | Add |
| Rock Springs Capital Management LP |
| 1.58% | 1.5% | #14 | $32.3M | 967,855 | $25.5M | 1.2M | -250,918-20.59% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #193 | $32.3M | 965,871 | $23.8M | 1.1M | -169,927-14.96% | Reduce |
| Jefferies Financial Group Inc. |
| 0.2% | <0.01% | #39 | $31.0M | 929,626 | $324,474 | 15,488 | +914,138+5,902.23% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #169 | $30.7M | 920,314 | $11.2M | 535,566 | +384,748+71.84% | Add |
| Eagle Health Investments LP |
| 4.89% | 3.24% | #3 | $29.5M | 884,121 | $18.5M | 884,121 | 00.00% | Unchanged |
| Qube Research & Technologies Ltd |
| 0.03% | 0.02% | #84 | $29.5M | 882,219 | $19.2M | 914,760 | -32,541-3.56% | Reduce |
| Russell Investments Group, Ltd. |
| 0.02% | 0.01% | #95 | $26.2M | 784,099 | $8.4M | 402,959 | +381,140+94.59% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.02% | #126 | $25.4M | 760,825 | $37.1M | 1.8M | -1.0M-57.07% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #172 | $25.4M | 760,039 | $11.7M | 558,486 | +201,553+36.09% | Add |
| Nuveen, LLC |
| 0.01% | <0.01% | #145 | $23.2M | 693,959 | $13.9M | 662,054 | +31,905+4.82% | Add |
| Pictet Asset Management Holding SA |
| 0.02% | 0.01% | #91 | $23.2M | 753,695 | $11.7M | 603,571 | +150,124+24.87% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #152 | $22.4M | 671,411 | $12.7M | 608,219 | +63,192+10.39% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #188 | $22.0M | 657,699 | $17.4M | 832,740 | -175,041-21.02% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #205 | $21.2M | 635,338 | $7.8M | 370,597 | +264,741+71.44% | Add |
| GREAT POINT PARTNERS LLC |
| 3.79% | — | #6 | $20.0M | 600,000 | $0 | 0 | +600,000 | New Buy |
| Palo Alto Investors LP |
| 2.91% | 1.91% | #7 | $19.9M | 596,495 | $12.5M | 596,495 | 00.00% | Unchanged |
| SPHERA FUNDS MANAGEMENT LTD. |
| 2.57% | 2.69% | #9 | $19.6M | 588,494 | $17.0M | 809,333 | -220,839-27.29% | Reduce |
| Legal & General Group Plc |
| <0.01% | <0.01% | #161 | $19.6M | 586,520 | $12.4M | 590,294 | -3,774-0.64% | Reduce |
| PANAGORA ASSET MANAGEMENT INC |
| 0.06% | — | #65 | $19.6M | 586,230 | $0 | 0 | +586,230 | New Buy |
| FMR LLC |
| <0.01% | <0.01% | #234 | $19.3M | 576,849 | $6.0M | 287,316 | +289,533+100.77% | Add |
| Trexquant Investment LP |
| 0.11% | 0.06% | #48 | $18.6M | 556,385 | $8.2M | 389,467 | +166,918+42.86% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | <0.01% | #128 | $16.6M | 498,167 | $10.3M | 490,783 | +7,384+1.50% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #191 | $15.7M | 470,697 | $7.1M | 341,125 | +129,572+37.98% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #233 | $15.3M | 493,126 | $4.7M | 245,928 | +247,198+100.52% | Add |
| TORONTO DOMINION BANK |
| 0.02% | <0.01% | #102 | $13.9M | 415,000 | $3,394 | 162 | +414,838+256,072.84% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.02% | 0.02% | #97 | $13.8M | 413,700 | $11.8M | 561,700 | -148,000-26.35% | Reduce |
