| FMR LLC |
| 0.06% | 0.05% | #71 | $1.42B | 12.3M | $974.5M | 11.7M | +649,306+5.55% | Add |
| BAKER BROS. ADVISORS LP |
| 4.97% | 4.14% | #6 | $992.7M | 8.7M | $721.1M | 8.7M | 00.00% | Unchanged |
| Avoro Capital Advisors LLC |
| 7.7% | 6.12% | #4 | $857.1M | 7.5M | $622.6M | 7.5M | 00.00% | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.08% | 0.06% | #66 | $815.6M | 7.1M | $504.8M | 6.1M | +1.1M+17.36% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.47% | 0.31% | #32 | $717.5M | 6.3M | $455.2M | 5.5M | +792,264+14.50% | Add |
| BlackRock, Inc. |
| 0.01% | 0.01% | #125 | $635.1M | 5.5M | $421.5M | 5.1M | +477,334+9.43% | Add |
| BVF INC/IL |
| 11.35% | 14.6% | #3 | $444.0M | 3.9M | $458.3M | 5.5M | -1.6M-29.63% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.07% | 0.06% | #68 | $421.4M | 3.7M | $324.0M | 3.9M | -214,659-5.52% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.02% | 0.01% | #107 | $343.1M | 3.0M | $239.4M | 2.9M | +118,137+4.11% | Add |
| Siren, L.L.C. |
| 6.81% | 7.36% | #5 | $336.7M | 2.9M | $265.4M | 3.2M | -251,000-7.88% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #142 | $336.3M | 2.9M | $239.9M | 2.9M | +52,054+1.81% | Add |
| Atlas Venture Life Science Advisors, LLC |
| 37.05% | 48.26% | #1 | $326.5M | 2.8M | $381.3M | 4.6M | -1.7M-37.80% | Reduce |
| STATE STREET CORP |
| 0.01% | 0.01% | #126 | $313.9M | 2.7M | $199.0M | 2.4M | +347,459+14.54% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #122 | $208.3M | 1.8M | $137.1M | 1.6M | +170,981+10.39% | Add |
| Capital Research Global Investors |
| 0.02% | 0.02% | #95 | $159.3M | 1.4M | $139.4M | 1.7M | -284,394-17.00% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #120 | $136.2M | 1.2M | $74.0M | 888,409 | +298,924+33.65% | Add |
| UBS Group AG |
| 0.01% | 0.01% | #111 | $115.6M | 1.0M | $85.3M | 1.0M | -16,075-1.57% | Reduce |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.61% | 0.64% | #29 | $105.4M | 919,233 | $86.9M | 1.0M | -124,350-11.92% | Reduce |
| Merck & Co., Inc. |
| 16.82% | 18.4% | #2 | $88.5M | 772,165 | $64.3M | 772,165 | 00.00% | Unchanged |
| NORGES BANK |
| 0.01% | <0.01% | #130 | $86.8M | 757,246 | $1.4M | 49,697 | +707,549+1,423.73% | Add |
| FEDERATED HERMES, INC. |
| 0.12% | 0.07% | #55 | $85.9M | 749,398 | $44.7M | 536,680 | +212,718+39.64% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.02% | 0.01% | #106 | $85.4M | 745,152 | $49.4M | 592,879 | +152,273+25.68% | Add |
| FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.79% | 0.65% | #24 | $85.0M | 740,866 | $63.3M | 759,848 | -18,982-2.50% | Reduce |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.02% | 0.02% | #109 | $84.5M | 736,866 | $73.0M | 875,872 | -139,006-15.87% | Reduce |
| ALLIANCEBERNSTEIN L.P. |
| 0.03% | 0.02% | #88 | $81.8M | 981,521 | $69.1M | 888,035 | +93,486+10.53% | Add |
| Holocene Advisors, LP |
| 0.16% | 0.17% | #48 | $73.0M | 636,579 | $69.7M | 836,759 | -200,180-23.92% | Reduce |
| NORTHERN TRUST CORP |
| 0.01% | 0.01% | #138 | $66.7M | 581,907 | $41.2M | 494,439 | +87,468+17.69% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #137 | $60.7M | 529,729 | $41.3M | 495,262 | +34,467+6.96% | Add |
| FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #118 | $59.1M | 515,050 | $30.1M | 361,772 | +153,278+42.37% | Add |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 0.77% | 0.86% | #25 | $57.8M | 504,210 | $52.2M | 626,925 | -122,715-19.57% | Reduce |
| JENNISON ASSOCIATES LLC |
| 0.03% | 0.03% | #81 | $57.7M | 502,978 | $42.4M | 508,999 | -6,021-1.18% | Reduce |
| Woodline Partners LP |
| 0.18% | 0.06% | #45 | $57.4M | 500,868 | $17.0M | 203,585 | +297,283+146.02% | Add |
| Rock Springs Capital Management LP |
| 2.54% | 2.44% | #14 | $52.0M | 453,156 | $41.4M | 496,871 | -43,715-8.80% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #121 | $51.6M | 449,731 | $35.6M | 427,382 | +22,349+5.23% | Add |
| Boxer Capital Management, LLC |
| 3.71% | 3.6% | #7 | $49.2M | 429,100 | $27.4M | 329,100 | +100,000+30.39% | Add |
| Pictet Asset Management Holding SA |
| 0.04% | 0.04% | #80 | $45.0M | 395,540 | $38.8M | 468,728 | -73,188-15.61% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #175 | $43.4M | 378,286 | $24.1M | 289,416 | +88,870+30.71% | Add |
| BRAIDWELL LP |
| 1.6% | 0.94% | #17 | $43.4M | 378,163 | $28.1M | 337,559 | +40,604+12.03% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.02% | 0.01% | #96 | $43.1M | 375,868 | $23.8M | 285,871 | +89,997+31.48% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.03% | 0.02% | #85 | $42.6M | 371,374 | $21.4M | 256,501 | +114,873+44.78% | Add |
| Clearbridge Investments, LLC |
| 0.03% | — | #82 | $39.8M | 347,221 | $0 | 0 | +347,221 | New Buy |
| Octagon Capital Advisors LP |
| 3.2% | 3.92% | #8 | $35.5M | 310,000 | $35.4M | 425,000 | -115,000-27.06% | Reduce |
| Nextech Invest Ltd. |
| 1.52% | 1.63% | #18 | $32.0M | 278,896 | $23.2M | 278,896 | 00.00% | Unchanged |
| Alyeska Investment Group, L.P. |
| 0.08% | 0.08% | #65 | $31.7M | 276,455 | $28.5M | 342,698 | -66,243-19.33% | Reduce |
| TD ASSET MANAGEMENT INC |
| 0.03% | 0.02% | #89 | $31.3M | 272,900 | $23.9M | 287,100 | -14,200-4.95% | Reduce |
| VOYA INVESTMENT MANAGEMENT LLC |
| 0.03% | 0.02% | #91 | $31.0M | 269,914 | $16.6M | 198,808 | +71,106+35.77% | Add |
| Commodore Capital LP |
| 1.71% | 3.61% | #16 | $28.7M | 250,000 | $62.5M | 750,000 | -500,000-66.67% | Reduce |
| RTW INVESTMENTS, LP |
| 0.23% | 0.2% | #42 | $27.5M | 240,000 | $20.0M | 240,000 | 00.00% | Unchanged |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | 0.01% | #129 | $26.8M | 233,713 | $17.4M | 209,005 | +24,708+11.82% | Add |
| GILDER GAGNON HOWE & CO LLC |
| 0.27% | 0.24% | #38 | $26.3M | 229,053 | $19.6M | 235,433 | -6,380-2.71% | Reduce |
