| Sofinnova Investments, Inc. |
| 0.03% | 0.02% | #4 | $530,226 | 137,721 | $556,393 | 137,721 | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #10 | $379,706 | 98,625 | $311,989 | 77,225 | +21,400+27.71% | Add |
| Vivo Capital, LLC |
| 0.03% | 0.02% | #6 | $278,794 | 72,414 | $292,553 | 72,414 | 00.00% | Unchanged |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #13 | $219,077 | 56,903 | $40,840 | 10,109 | +46,794+462.89% | Add |
| T3 Companies, LLC |
| 0.16% | 0.17% | #1 | $146,300 | 38,000 | $153,520 | 38,000 | 00.00% | Unchanged |
| Board of Trustees of The Leland Stanford Junior University |
| 0.03% | 0.02% | #5 | $138,511 | 35,977 | $145,347 | 35,977 | 00.00% | Unchanged |
| PFIZER INC |
| 0.08% | 0.06% | #3 | $133,832 | 31,305 | $137,116 | 31,305 | 00.00% | Unchanged |
| Lynx1 Capital Management LP |
| 0.02% | 0.02% | #7 | $118,580 | 30,800 | $124,432 | 30,800 | 00.00% | Unchanged |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
| 0.08% | 0.1% | #2 | $105,875 | 27,500 | $111,100 | 27,500 | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #15 | $73,622 | 19,119 | $116,329 | 28,791 | -9,672-33.59% | Reduce |
| Shay Capital LLC |
| <0.01% | 0.01% | #9 | $59,436 | 15,438 | $60,216 | 14,905 | +533+3.58% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #20 | $37,388 | 9,711 | $39,233 | 9,711 | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #19 | $27,181 | 7,060 | $28,522 | 7,060 | 00.00% | Unchanged |
| Nan Fung Group Holdings Ltd |
| 0.01% | 0.1% | #8 | $19,250 | 5,000 | $118,170 | 29,250 | -24,250-82.91% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #18 | $12,108 | 3,145 | $16,641 | 3,128 | +17+0.54% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #16 | $11,916 | 3,095 | $12,504 | 3,095 | 00.00% | Unchanged |
| NewEdge Advisors, LLC |
| <0.01% | — | #12 | $9,740 | 2,530 | $0 | 0 | +2,530 | New Buy |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #11 | $6,584 | 1,710 | $4,416 | 1,093 | +617+56.45% | Add |
| MERCER GLOBAL ADVISORS INC /ADV |
| <0.01% | — | #17 | $1,124 | 292 | $0 | 0 | +292 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #21 | $982 | 255 | $3,179 | 787 | -532-67.60% | Reduce |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #14 | $501 | 130 | $40 | 10 | +120+1,200.00% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #23 | $165 | 42 | $179 | 42 | 00.00% | Unchanged |
| CITIGROUP INC |
| <0.01% | — | #22 | $158 | 41 | $0 | 0 | +41 | New Buy |
| BARCLAYS PLC |
| <0.01% | <0.01% | #24 | $23 | 6 | $24 | 6 | 00.00% | Unchanged |
