| Jupiter Topco LLC |
| 0.26% | — | #39 | $643.3M | 11.3M | $0 | 0 | +11.3M | New Buy |
| BlackRock, Inc. |
| 0.01% | <0.01% | #155 | $455.7M | 8.0M | $231.5M | 7.8M | +228,630+2.93% | Add |
| FMR LLC |
| 0.02% | 0.02% | #108 | $403.2M | 7.1M | $325.9M | 11.0M | -3.9M-35.30% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| 0.02% | <0.01% | #111 | $259.5M | 4.6M | $40.0M | 1.3M | +3.2M+239.63% | Add |
| STATE STREET CORP |
| 0.01% | 0.01% | #153 | $241.8M | 4.3M | $147.4M | 5.0M | -703,764-14.19% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #168 | $233.4M | 4.1M | $120.2M | 4.0M | +62,882+1.55% | Add |
| PERCEPTIVE ADVISORS LLC |
| 3.2% | 2.4% | #9 | $213.2M | 3.8M | $123.1M | 4.1M | -389,977-9.41% | Reduce |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.24% | 0.17% | #41 | $159.8M | 2.8M | $97.2M | 3.3M | -457,999-14.00% | Reduce |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.2% | 0.04% | #43 | $146.0M | 2.6M | $29.0M | 977,000 | +1.6M+162.98% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #152 | $134.8M | 2.4M | $70.4M | 2.4M | +2,328+0.10% | Add |
| Rock Springs Capital Management LP |
| 6.04% | 2.59% | #2 | $123.8M | 2.2M | $43.9M | 1.5M | +701,115+47.44% | Add |
| ARMISTICE CAPITAL, LLC |
| 1.44% | 2.59% | #16 | $117.7M | 2.1M | $145.5M | 4.9M | -2.8M-57.68% | Reduce |
| Kynam Capital Management, LP |
| 6.28% | 4.44% | #1 | $113.6M | 2.0M | $72.0M | 2.4M | -423,918-17.49% | Reduce |
| Stephens Investment Management Group LLC |
| 1.14% | 0.73% | #18 | $106.5M | 1.9M | $53.4M | 1.8M | +76,838+4.27% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.14% | 0.09% | #49 | $104.1M | 1.8M | $58.4M | 2.0M | -133,700-6.80% | Reduce |
| EMERALD ADVISERS, LLC |
| 2.14% | 1.46% | #11 | $90.9M | 1.6M | $46.3M | 1.6M | +43,690+2.81% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.06% | 0.04% | #62 | $88.9M | 1.6M | $44.8M | 1.5M | +57,397+3.81% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #176 | $87.6M | 1.5M | $50.8M | 1.7M | -167,522-9.80% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #149 | $87.2M | 1.5M | $51.1M | 1.7M | -184,400-10.72% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | 0.01% | #113 | $87.1M | 1.5M | $30.4M | 1.0M | +510,808+49.97% | Add |
| Qube Research & Technologies Ltd |
| 0.08% | 0.02% | #59 | $82.0M | 1.4M | $19.9M | 669,159 | +774,071+115.68% | Add |
| D. E. Shaw & Co., Inc. |
| 0.04% | 0.01% | #80 | $81.8M | 1.4M | $24.9M | 836,544 | +603,925+72.19% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.47% | 0.28% | #31 | $81.8M | 1.4M | $38.1M | 1.3M | +156,616+12.21% | Add |
| JANE STREET GROUP, LLC |
| 0.01% | <0.01% | #157 | $76.7M | 1.4M | $16.1M | 542,380 | +807,819+148.94% | Add |
| MARSHALL WACE, LLP |
| 0.06% | 0.01% | #64 | $75.7M | 1.3M | $5.3M | 178,536 | +1.2M+646.74% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #150 | $74.9M | 1.3M | $12.0M | 404,805 | +913,811+225.74% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.03% | <0.01% | #89 | $65.7M | 1.2M | $3.2M | 109,382 | +1.0M+957.72% | Add |
| MPM BioImpact LLC |
| 3.89% | 2.6% | #6 | $63.8M | 1.1M | $33.7M | 1.1M | -10,634-0.94% | Reduce |
| Nuveen, LLC |
| 0.01% | 0.01% | #117 | $59.9M | 1.1M | $27.9M | 938,569 | +116,064+12.37% | Add |
| EMERALD MUTUAL FUND ADVISERS TRUST |
| 2.06% | 1.36% | #12 | $58.6M | 1.0M | $28.1M | 945,033 | +86,991+9.21% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #177 | $50.2M | 883,631 | $32.5M | 1.1M | -210,227-19.22% | Reduce |
| NORTHERN TRUST CORP |
| 0.01% | <0.01% | #162 | $49.7M | 875,008 | $23.2M | 781,418 | +93,590+11.98% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | <0.01% | #158 | $47.0M | 827,278 | $23.5M | 790,812 | +36,466+4.61% | Add |
| Eversept Partners, LP |
| 2.35% | 0.85% | #10 | $45.4M | 798,973 | $16.1M | 542,610 | +256,363+47.25% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | <0.01% | #140 | $37.6M | 661,824 | $18.2M | 612,622 | +49,202+8.03% | Add |
| Ensign Peak Advisors, Inc |
| 0.06% | 0.04% | #67 | $33.6M | 591,815 | $21.3M | 715,707 | -123,892-17.31% | Reduce |
| T. Rowe Price Investment Management, Inc. |
| 0.02% | 0.01% | #98 | $33.0M | 581,393 | $15.5M | 520,604 | +60,789+11.68% | Add |
| Fiera Capital Corp |
| 0.11% | 0.09% | #56 | $29.4M | 516,997 | $26.8M | 900,868 | -383,871-42.61% | Reduce |
| PANAGORA ASSET MANAGEMENT INC |
| 0.09% | 0.07% | #58 | $27.9M | 490,724 | $17.6M | 592,912 | -102,188-17.23% | Reduce |
| Point72 Asset Management, L.P. |
| 0.03% | — | #91 | $27.2M | 478,860 | $0 | 0 | +478,860 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #182 | $26.9M | 473,456 | $25.5M | 856,757 | -383,301-44.74% | Reduce |
| LOOMIS SAYLES & CO L P |
| 0.03% | 0.01% | #86 | $26.8M | 470,914 | $9.0M | 301,466 | +169,448+56.21% | Add |
| Legal & General Group Plc |
| 0.01% | <0.01% | #163 | $26.7M | 470,400 | $13.4M | 451,056 | +19,344+4.29% | Add |
| Candriam S.C.A. |
| 0.12% | 0.09% | #52 | $26.7M | 470,265 | $17.9M | 468,556 | +1,709+0.36% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #204 | $26.1M | 459,315 | $15.6M | 523,711 | -64,396-12.30% | Reduce |
| Graham Capital Management, L.P. |
| 0.46% | — | #32 | $25.4M | 446,696 | $0 | 0 | +446,696 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #228 | $24.4M | 429,253 | $26.7M | 1.1M | -687,784-61.57% | Reduce |
| Assenagon Asset Management S.A. |
| 0.03% | <0.01% | #90 | $24.3M | 427,305 | $235,511 | 7,927 | +419,378+5,290.50% | Add |
| GW&K Investment Management, LLC |
| 0.18% | 0.04% | #46 | $23.0M | 404,208 | $4.2M | 140,458 | +263,750+187.78% | Add |
| Russell Investments Group, Ltd. |
| 0.02% | 0.01% | #109 | $22.5M | 395,969 | $7.0M | 234,265 | +161,704+69.03% | Add |
