| Commodore Capital LP |
| 0.04% | — | #3 | $630,228 | 2.8M | $0 | 0 | +2.8M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #32 | $355,769 | 1.6M | $900,442 | 1.6M | 00.00% | Unchanged |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #21 | $191,646 | 847,992 | $268,387 | 469,619 | +378,373+80.57% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #18 | $179,575 | 794,579 | $336,000 | 589,663 | +204,916+34.75% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #17 | $165,093 | 730,500 | $166,478 | 291,300 | +439,200+150.77% | Add |
| Ikarian Capital, LLC |
| 0.01% | 0.02% | #4 | $117,311 | 519,077 | $296,654 | 519,077 | 00.00% | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #31 | $105,731 | 459,700 | $104,528 | 183,007 | +276,693+151.19% | Add |
| AdvisorShares Investments LLC |
| 0.01% | 0.03% | #5 | $99,133 | 438,643 | $158,368 | 277,110 | +161,533+58.29% | Add |
| LUMINUS MANAGEMENT LLC |
| 0.06% | 0.14% | #2 | $91,104 | 403,115 | $226,344 | 396,053 | +7,062+1.78% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #37 | $82,514 | 365,002 | $259,170 | 453,391 | -88,389-19.50% | Reduce |
| ADAR1 Capital Management, LLC |
| <0.01% | 0.03% | #7 | $79,358 | 351,141 | $429,277 | 751,141 | -400,000-53.25% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #42 | $78,068 | 345,432 | $256,322 | 448,507 | -103,075-22.98% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #27 | $69,292 | 306,600 | $368,277 | 644,404 | -337,804-52.42% | Reduce |
| GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #24 | $68,791 | 304,385 | $11,359 | 19,875 | +284,510+1,431.50% | Add |
| Verdad Advisers, LP |
| 0.06% | 0.12% | #1 | $66,296 | 293,343 | $105,692 | 184,938 | +108,405+58.62% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #35 | $60,077 | 265,827 | $169,171 | 296,011 | -30,184-10.20% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #33 | $52,645 | 232,939 | $157,106 | 274,900 | -41,961-15.26% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #30 | $49,200 | 217,700 | $124,524 | 217,700 | 00.00% | Unchanged |
| TUDOR INVESTMENT CORP ET AL |
| <0.01% | <0.01% | #25 | $37,742 | 167,000 | $60,677 | 106,172 | +60,828+57.29% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| <0.01% | <0.01% | #14 | $30,413 | 134,571 | $76,907 | 134,571 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #45 | $27,372 | 121,114 | $69,217 | 121,114 | 00.00% | Unchanged |
| XTX Topco Ltd |
| <0.01% | <0.01% | #15 | $26,754 | 118,380 | $87,353 | 152,849 | -34,469-22.55% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #38 | $18,266 | 80,823 | $41,522 | 72,655 | +8,168+11.24% | Add |
| STEMPOINT CAPITAL LP |
| <0.01% | 0.01% | #9 | $17,276 | 616,749 | $58,187 | 616,749 | 00.00% | Unchanged |
| Virtu Financial LLC |
| <0.01% | — | #13 | $14,921 | 66,021 | $0 | 0 | +66,021 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #40 | $13,070 | 57,830 | $45,037 | 78,736 | -20,906-26.55% | Reduce |
| DIADEMA PARTNERS LP |
| <0.01% | 0.01% | #10 | $13,040 | 57,700 | $60,252 | 105,428 | -47,728-45.27% | Reduce |
| GSA CAPITAL PARTNERS LLP |
| <0.01% | <0.01% | #11 | $12,336 | 54,584 | $28,000 | 49,842 | +4,742+9.51% | Add |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #29 | $10,076 | 43,888 | $2,357 | 4,133 | +39,755+961.89% | Add |
| Confluence Wealth Services, Inc. |
| <0.01% | — | #19 | $7,370 | 32,610 | $0 | 0 | +32,610 | New Buy |
| Scientech Research LLC |
| 0.01% | — | #6 | $6,844 | 30,283 | $0 | 0 | +30,283 | New Buy |
| StoneX Group Inc. |
| <0.01% | <0.01% | #16 | $6,621 | 10,840 | $8,686 | 15,198 | -4,358-28.67% | Reduce |
| R Squared Ltd |
| <0.01% | — | #8 | $6,270 | 27,745 | $0 | 0 | +27,745 | New Buy |
| Kestra Advisory Services, LLC |
| <0.01% | <0.01% | #28 | $5,876 | 26,000 | $14,859 | 26,000 | 00.00% | Unchanged |
| HighTower Advisors, LLC |
| <0.01% | <0.01% | #36 | $4,662 | 20,628 | $11,789 | 20,628 | 00.00% | Unchanged |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #23 | $4,099 | 18,136 | $898 | 1,572 | +16,564+1,053.69% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | — | #49 | $3,745 | 16,570 | $0 | 0 | +16,570 | New Buy |
| Truvestments Capital LLC |
| <0.01% | <0.01% | #12 | $3,512 | 15,540 | $9,711 | 16,992 | -1,452-8.55% | Reduce |
| Farther Finance Advisors, LLC |
| <0.01% | — | #26 | $3,390 | 15,000 | $0 | 0 | +15,000 | New Buy |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #44 | $3,356 | 14,851 | $8,507 | 14,884 | -33-0.22% | Reduce |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #39 | $3,230 | 14,295 | $51,279 | 89,649 | -75,354-84.05% | Reduce |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #46 | $2,760 | 12,000 | $0 | 0 | +12,000 | New Buy |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #43 | $2,443 | 10,809 | $6,183 | 10,809 | 00.00% | Unchanged |
| Performa Ltd (US), LLC |
| <0.01% | <0.01% | #20 | $1,243 | 5,500 | $4,286 | 7,500 | -2,000-26.67% | Reduce |
| CITIGROUP INC |
| <0.01% | <0.01% | #48 | $864 | 3,822 | $1 | 1 | +3,821+382,100.00% | Add |
| Persistent Asset Partners Ltd |
| <0.01% | 0.01% | #22 | $394 | 147 | $15,209 | 26,612 | -26,465-99.45% | Reduce |
| Integrated Wealth Concepts LLC |
| <0.01% | — | #47 | $126 | 556 | $0 | 0 | +556 | New Buy |
| JONES FINANCIAL COMPANIES LLLP |
| <0.01% | <0.01% | #50 | $80 | 114 | $65 | 114 | 00.00% | Unchanged |
| MORGAN STANLEY |
| <0.01% | <0.01% | #51 | $67 | 298 | $97,746 | 27,534 | -27,236-98.92% | Reduce |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #41 | $65 | 289 | $165 | 288 | +1+0.35% | Add |
