| Ikarian Capital, LLC |
| 1.15% | 1.1% | #1 | $10.8M | 4.5M | $13.5M | 5.5M | -994,552-17.97% | Reduce |
| 683 Capital Management, LLC |
| 0.15% | 0.12% | #5 | $3.1M | 1.3M | $2.4M | 900,000 | +385,000+42.78% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.03% | 0.04% | #13 | $2.3M | 973,732 | $3.3M | 1.3M | -297,850-23.42% | Reduce |
| BlackRock, Inc. |
| <0.01% | — | #30 | $2.1M | 871,653 | $0 | 0 | +871,653 | New Buy |
| PERCEPTIVE ADVISORS LLC |
| 0.03% | 0.04% | #14 | $1.9M | 792,696 | $2.1M | 792,696 | 00.00% | Unchanged |
| ADAR1 Capital Management, LLC |
| 0.08% | 0.11% | #10 | $1.7M | 700,000 | $1.9M | 742,400 | -42,400-5.71% | Reduce |
| BML Capital Management, LLC |
| 0.78% | 0.69% | #2 | $1.4M | 573,287 | $1.1M | 408,887 | +164,400+40.21% | Add |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.13% | — | #7 | $1.3M | 545,000 | $0 | 0 | +545,000 | New Buy |
| Richmond Brothers, Inc. |
| 0.66% | 0.83% | #3 | $1.3M | 535,612 | $1.2M | 476,584 | +59,028+12.39% | Add |
| Knott David M Jr |
| 0.56% | 0.61% | #4 | $1.1M | 444,862 | $1.0M | 387,835 | +57,027+14.70% | Add |
| Stonepine Capital Management, LLC |
| 0.13% | 0.33% | #8 | $866,925 | 364,254 | $812,200 | 310,000 | +54,254+17.50% | Add |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #22 | $798,830 | 335,642 | $172,954 | 66,013 | +269,629+408.45% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #29 | $612,740 | 257,454 | $84,177 | 32,129 | +225,325+701.31% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #23 | $474,527 | 199,381 | $124,358 | 47,465 | +151,916+320.06% | Add |
| DIADEMA PARTNERS LP |
| 0.06% | 0.09% | #11 | $468,824 | 196,985 | $525,808 | 200,690 | -3,705-1.85% | Reduce |
| Burkehill Global Management, LP |
| 0.01% | 0.02% | #15 | $357,000 | 150,000 | $360,300 | 150,000 | 00.00% | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #32 | $286,666 | 120,448 | $849,163 | 324,108 | -203,660-62.84% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #41 | $244,557 | 102,755 | $0 | 0 | +102,755 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #24 | $207,774 | 87,300 | $316,234 | 120,700 | -33,400-27.67% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | — | #31 | $197,212 | 82,862 | $0 | 0 | +82,862 | New Buy |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #26 | $195,036 | 81,948 | $8,646 | 3,300 | +78,648+2,383.27% | Add |
| STATE STREET CORP |
| <0.01% | — | #48 | $158,746 | 66,700 | $0 | 0 | +66,700 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #34 | $158,153 | 66,451 | $86 | 33 | +66,418+201,266.67% | Add |
| Persistent Asset Partners Ltd |
| 0.04% | 0.05% | #12 | $118,698 | 49,873 | $132,957 | 50,747 | -874-1.72% | Reduce |
| Koa Wealth Management, LLC |
| 0.08% | 0.09% | #9 | $118,048 | 49,600 | $129,952 | 49,600 | 00.00% | Unchanged |
| FIFTH LANE CAPITAL, LP |
| 0.14% | 0.14% | #6 | $117,900 | 45,000 | $117,900 | 45,000 | 00.00% | Unchanged |
| NEW YORK STATE COMMON RETIREMENT FUND |
| <0.01% | — | #25 | $115,192 | 48,400 | $0 | 0 | +48,400 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #28 | $104,025 | 43,708 | $1.2M | 474,601 | -430,893-90.79% | Reduce |
| Quadrature Capital Ltd |
| <0.01% | — | #20 | $100,681 | 42,303 | $0 | 0 | +42,303 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #43 | $97,390 | 40,920 | $41,063 | 15,673 | +25,247+161.09% | Add |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #37 | $97,000 | 40,940 | $106,000 | 40,400 | +540+1.34% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #38 | $87,489 | 36,760 | $0 | 0 | +36,760 | New Buy |
| XTX Topco Ltd |
| <0.01% | <0.01% | #19 | $68,208 | 28,659 | $107,755 | 41,128 | -12,469-30.32% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | — | #42 | $57,008 | 23,953 | $0 | 0 | +23,953 | New Buy |
| Nuveen, LLC |
| <0.01% | — | #40 | $47,060 | 19,773 | $0 | 0 | +19,773 | New Buy |
| Y-Intercept (Hong Kong) Ltd |
| <0.01% | — | #21 | $35,864 | 15,069 | $0 | 0 | +15,069 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | — | #47 | $31,511 | 13,240 | $0 | 0 | +13,240 | New Buy |
| SmartHarvest Portfolios, LLC |
| 0.01% | 0.01% | #16 | $30,695 | 12,897 | $33,790 | 12,897 | 00.00% | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #49 | $29,676 | 12,469 | $0 | 0 | +12,469 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #53 | $27,889 | 11,718 | $351 | 121 | +11,597+9,584.30% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #45 | $26,927 | 11,314 | $0 | 0 | +11,314 | New Buy |
| MONOGRAPH WEALTH ADVISORS, LLC |
| <0.01% | <0.01% | #18 | $26,489 | 11,130 | $29,161 | 11,130 | 00.00% | Unchanged |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #35 | $26,124 | 10,979 | $2,043 | 780 | +10,199+1,307.56% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #56 | $20,561 | 8,639 | $151 | 100 | +8,539+8,539.00% | Add |
| CITIGROUP INC |
| <0.01% | <0.01% | #46 | $16,627 | 6,986 | $3 | 1 | +6,985+698,500.00% | Add |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
| <0.01% | — | #36 | $16,432 | 6,904 | $0 | 0 | +6,904 | New Buy |
| FNY Investment Advisers, LLC |
| <0.01% | 0.01% | #17 | $11,900 | 5,000 | $13,000 | 5,000 | 00.00% | Unchanged |
| BARCLAYS PLC |
| <0.01% | — | #54 | $6,852 | 2,879 | $0 | 0 | +2,879 | New Buy |
| Legal & General Group Plc |
| <0.01% | — | #55 | $5,748 | 2,415 | $0 | 0 | +2,415 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | — | #50 | $5,450 | 2,290 | $0 | 0 | +2,290 | New Buy |
